Material to form a hydrogel

Abstract

A soft film, a sponge, or a sheet in the dried state is provided, which is capable of forming a hydrogel absorbing water or blood. The film is obtainable by preparing a film-state material in the dried state from either a solution of poly(acrylic acid) or a solution of polyvinylpyrrolidone, and bringing the film-state material into contact with the other remaining solution, and then drying or freeze-drying it.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation application from International Patent Application No. PCT / JP2013 / 078612, filed Oct. 22, 2013, claiming the benefit of the conventional priority from Japanese Patent Application No. 2012-233453, filed Oct. 23, 2012; and Japanese Patent Application No. 2013-109515, filed May 24, 2013, and their entire contents of which are incorporated herein by reference.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to a film or sponge which can be utilized for an adhesion barrier or hemostatic device.[0004]Specifically, the present invention relates to a film or sponge which can be provided as a soft film or sponge in the dried state, and can form a hydrogel absorbing water or blood.[0005]2. Background Art[0006]A hydrogel which can adhere to a bio-tissue has been widely explored to be applied to an adhesion barrier, hemostatic device, wound covering material, or drug-releas...

AI Technical Summary

Benefits of technology

The present invention provides a film, sponge, papyraceous sheet, and powder that contain poly(acrylic acid) and polyvinylpyrrolidone to form a hydrogel. The hydrogel can be applied to a tissue surface or bleeding site and absorb water or blood while strongly adhering to the application site. The film, sponge, papyraceous sheet, and powder are safe and can be used as a medical treatment material. The hydrogel is slow degraded and solubilized under physiological conditions after being applied, and it is safe to place it in a body as an adhesion barrier. The invention also provides a method for preparing the solid film containing poly(acrylic acid) or polyvinylpyrrolidone.

Problems solved by technology

Hydrogels derived from animal protein is known, but they have the risk of infection of viruses or bovine spongiform encephalopathy, or immune response to foreign proteins.

However, crosslinked natural polysaccharides are not very flexible in the dried state, difficult in fitting to a complex shape, and thus, have a difficulty in using as an adhesion barrier.

There is a problem that the chemically crosslinked gel is hard to be bio-absorbed.

However, the biocompatibility of the gels of synthetic polymers is low, and there is a problem that the preparation of them is generally complicated.

Therefore, there is a problem that the film or sponge to form hydrogel cannot be prepared by merely mixing the aqueous solutions.

However, if the aggregate is rehydrated, it does not absorb water and remains as a solid, and a hydrogel cannot be reproduced.

However, these technologies are not for utilizing the hydrogel comprising poly(acrylic acid) and polyvinylpyrrolidone as a material or treatment material for medical use.

Thus, in those publications, no indication nor instruction for the technology to reproduce the hydrogel by rehydration of the isolated and dried gel is found.