Adjustable macaque spinal cord injury method

A technique for spinal cord injury and rhesus monkeys, applied in the field of medical animal research, can solve the problems of high lethality, waste of resources, and large surgical trauma, and achieve the effects of low animal lethality, long-lasting modeling effect, and low lethality.

Pending Publication Date: 2020-09-15
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods have the following problems: 1) The operation is complicated, the surgical trauma is large, and the lethality is high
2) The degree of injury cannot be adjusted. Whether it is one-sided injury or total spinal cord injury, it will directly cause direct paraplegia of the corresponding limbs. Clinically, mild symptoms such as paresthesia, fine motor disturbance, and claudication cannot be simulated.
3) The damage is irreversible, but clinically, patients with spinal cord tumors and herniated intervertebral dis...

Method used

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  • Adjustable macaque spinal cord injury method
  • Adjustable macaque spinal cord injury method
  • Adjustable macaque spinal cord injury method

Examples

Experimental program
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Effect test

Embodiment 1

[0038] A controllable method for macaque spinal cord injury, comprising the steps of:

[0039] 1) MRI scanning was performed before the operation in macaques to determine the position of the 10th thoracic vertebra, and at the same time measure the diameter of the spinal canal corresponding to the 10th thoracic vertebra.

[0040] 2) Maintain aseptic operation during macaque surgery, confirm the position of the 10th thoracic vertebra according to the preoperative positioning, incise the skin in turn, and stretch the ligamentum flavum to both sides along the gap between the 10th and 11th thoracic vertebrae. The balloon was implanted into the right epidural space in the spinal canal corresponding to the 10th thoracic vertebra through this space, and the water injection port at the end of the balloon was extended to the subcutaneous area. Inject a small amount of normal saline into the balloon, suture the incision layer by layer, bury the water injection port of the balloon under t...

Embodiment 2

[0044] A controllable method for macaque spinal cord injury, comprising the steps of:

[0045] 1) MRI scanning was performed in macaques before the operation to determine the position of the 10th thoracic vertebra, and at the same time measure the diameter of the spinal canal corresponding to the 10th thoracic vertebra.

[0046] 2) Maintain aseptic operation during macaque surgery, confirm the position of the 10th thoracic vertebra according to the preoperative positioning, incise the skin in turn, and stretch the ligamentum flavum to both sides along the gap between the 10th and 11th thoracic vertebrae. The balloon was implanted into the right epidural space in the spinal canal corresponding to the 10th thoracic vertebra through this space, and the water injection port at the end of the balloon was extended to the subcutaneous area. Inject a small amount of normal saline into the balloon, suture the incision layer by layer, bury the water injection port of the balloon under t...

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Abstract

The invention relates to an adjustable macaque spinal cord injury method. An elastic saccule is transplanted in a target spinal cord segment of the vertebral canal of a macaque, a water injecting opening in the far end of the saccule is buried at a neighbouring subcutaneous position; normal saline of different volumes is injected in the saccule to manufacture macaque spinal cord injury models of different injury degrees. A method of using the saccule for pressing the vertebral canal of the macaque is adopted to construct the macaque spinal cord injury model of which the injury degree, the injury time interval and the injury position can be adjusted and controlled, so that the model construction effect is lasting, the injury is progressive, the injury degree behavior is visualized, trauma to the macaque is small, the lethality is low, and the method can be used for simulating and researching pathology injury mechanisms and treatment strategies of lesion of spinal cord trauma, intramedullary tumor/intradural-extramedullary tumor, intervertebral disk hernia, spinal cord congenital malformation, spinal cord infection and the like, and has important significance on preclinical test of various diseases.

Description

technical field [0001] The invention belongs to the technical field of medical animal research, and in particular relates to an adjustable spinal cord injury method for macaques. Background technique [0002] Spinal cord injury is a serious clinical disease. The life of patients with spinal cord injury is less directly threatened, and the survival period is long, but the quality of life is extremely low, and they are often unable to take care of themselves, which has caused a great burden on individuals, families and society. . Therefore, using experimental animals to prepare spinal cord injury models to study the pathological injury mechanism and treatment strategies of spinal cord injury is one of the urgent issues in biology and even the medical field. [0003] Most of the existing spinal cord injury models have been developed using rodents along with other small animals, the problem is that: [0004] 1) The spinal canal structure of rodents and other small animals is s...

Claims

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Application Information

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IPC IPC(8): A61D1/00A61D7/00
CPCA61D1/00A61D7/00
Inventor 邹杨鸿周广平张志婷林郁耿鑫李经辉徐玲杜玲丽余化霖彭琴王建红
Owner KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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