Use of small molecule compound in improving ability of host to remove pathogenic bacteria and preparing drugs resistant to pathogenic bacteria infection

Abstract

The invention relates to the technical field of biology, in particular to a use of a small molecule compound in improving the ability of a host to remove pathogenic bacteria and preparing drugs resistant to pathogenic bacteria infection. The metabonomics technology is utilized, the metabolic change in the serum of mice infected with the pathogenic bacteria is analyzed, and thereby the small molecule compound that can improve the ability of the host to remove and resist the pathogenic bacteria, reduce the content of the pathogenic bacteria in the host and improve a survival rate, and especiallycan improve the ability of the host to resist Staphylococcus aureus/MRSA infections is screened out. Aiming at the application of the small molecule compound, the effect of the small molecule compound is realized by taking the metabolic regulation of the immunity of the host as a cut-in point and regulating the own immunity of the host to resist pathogenic bacteria infections, so that the methodcan eliminate the risk of producing drug-resistant bacteria. In addition, the small molecule compound can better protect the host in synergy with an antibiotic, the shortening of a use period of the antibiotic is facilitated, and the production of drug-resistant bacteria is minimized.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the use of small molecule compounds for improving the host's ability to clear pathogenic bacteria and the use in the preparation of anti-pathogenic bacteria infection drugs. Background technique [0002] At present, antibiotics are used for the treatment of Staphylococcus aureus infection, leading to the emergence of drug-resistant bacteria such as MRSA, which makes it embarrassing for antibiotics to treat drug-resistant bacterial infections, and the invention of new antibiotics cannot keep up with the speed of bacterial resistance. The disadvantages of using antibiotics to treat Staphylococcus aureus infection are, on the one hand, antibiotic-resistant bacteria are produced very quickly, resulting in no antibiotics available for later treatment of drug-resistant bacteria; on the other hand, the screening period for new antibiotics is very long and the cost is high. At the same time,...

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the problems of using antibiotics to treat pathogenic bacteria infection, which will produce drug-resistant bacteria and the screening cycle of new antibiotics is long, etc., using metabolomics technology to screen anti-infection small molecules from the serum of infected mice, and screening out the anti-infection small molecules that can improve The ability and resistance of the host to pathogenic bacteria, and small molecular metabolites that reduce the content of pathogenic bacteria in the host, thereby providing a use of the screened small molecule compound for improving the ability of the host to clear pathogenic bacteria, and the screened small molecule Application of molecular compound in preparation of anti-pathogen infection medicine

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