Application of leonurine to prevention of acute liver injury and promotion of repair and regeneration of liver tissue

A technology of acute liver injury and leonurine, applied in the field of preventing acute liver injury and promoting liver tissue repair and regeneration with leonurine

Active Publication Date: 2020-09-29
王瑞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current use is limited to applications in uterine blood, myocardial ischemia, atherosclerosis, and diabetes

Method used

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  • Application of leonurine to prevention of acute liver injury and promotion of repair and regeneration of liver tissue
  • Application of leonurine to prevention of acute liver injury and promotion of repair and regeneration of liver tissue
  • Application of leonurine to prevention of acute liver injury and promotion of repair and regeneration of liver tissue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0173] Example 1, the role of SCM-198 in preventing acute liver injury

[0174] SCM-198 promotes the survival of L02 cells, a human hepatic parenchymal cell line

[0175] The results of acute liver injury cell model experiments show that SCM-198 has an obvious protective effect on L02 cells, specifically as follows: according to the detection results of lactate dehydrogenase content, such as Figure 1b As shown, SCM-198 can effectively reduce 3% H 2 o 2 Induced oxidative stress injury, the survival rate of L02 cells in the SCM-198 group increased by 65.76% compared with the placebo group; according to the results of cell activity CCK-8 detection, such as Figure 1c As shown, SCM-198 can effectively maintain the original cell function of L02 cells, and the activity of L02 cells in the SCM-198 group was increased by 127.46% compared with the placebo group; according to the detection results of the activity of the apoptosis protein Caspase-3, as shown in Figure 1d As shown,...

Embodiment 2

[0187] Example 2, the role of SCM-198 in promoting liver tissue repair and regeneration

[0188] SCM-198 inhibits the activation of human hepatic stellate cell line LX-2 cells

[0189] The results of liver fibrosis cell model experiments show that SCM-198 has a significant inhibitory effect on the activation of LX-2 cells, specifically as follows: according to the results of cell migration detection, such as Figure 3a As shown, the migration rate of LX-2 cells in the SCM-198 group was 20.61% lower than that in the placebo group. According to the results of Edu staining, such as Figure 3b As shown, the proliferation rate of LX-2 cells in the SCM-198 group was 80.97% lower than that in the placebo group. According to the detection results of cell α-SMA protein expression, such as Figure 3cIt showed that the expression of α-SMA protein in LX-2 cells in the SCM-198 group was 25.71% lower than that in the placebo group.

[0190] SCM-198 blocks the formation of mild liver...

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Abstract

The invention discloses an application of leonurine to preparation of medicines for preventing acute liver injury and medicines for promoting repair and regeneration of liver tissue. The leonurine hasprotection effects on the liver tissue, and can prevent the acute liver injury and can promote repair and regeneration of the liver tissue.

Description

technical field [0001] The invention relates to a new application of motherurine, in particular to the application of motherurine in the preparation of medicines for preventing acute liver injury and promoting liver tissue repair and regeneration. Background technique [0002] With the evolution of human living environment and style, the global incidence of acute and chronic liver diseases is increasing year by year. According to literature reports, SARS (Severe acute respiratory syndrome, SARS)-Cov and SARS-CoV-2 can directly bind to ACE2-positive bile duct cells and damage liver tissue. Acute liver injury events caused by virus (SARS-Cov, SARS-CoV-2) infection, systemic inflammatory factor storm, and drug (such as: aristolochic acid, acetaminophen, etc.) induction continue to occur. Liver fibrosis (Liver fibrosis, LF) is an inevitable pathological process of all chronic liver diseases, and it is also a pathological state of chronic liver injury caused by various reasons (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/235A61P1/16
CPCA61K31/235A61P1/16
Inventor 王瑞王余果余捷妮娜
Owner 王瑞
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