Application of small molecule compound to improvement of capacity of host for clearing pathogenic bacteria and to preparation of drug for resisting pathogenic bacterium infection

Abstract

The present invention relates to the technical field of biology, in particular to application of a small molecule compound to improvement of capacity of a host for clearing pathogenic bacteria and topreparation of a drug for resisting pathogenic bacterium infection. The present invention utilizes a metabonomics technology to analyze the metabolic changes in the serum of mice infected with pathogenic bacteria, thereby screening the small molecule compound which can improve the capacity of the host for clearing and resisting pathogenic bacteria, reduce the content of pathogenic bacteria in thehost, improve the survival rate, and especially improve the capacity of the host for resisting staphylococcus aureus / MRSA infection. The invention aims at the application of the small molecule compound, and the effect is achieved by taking metabolic regulation of the immunity of the host as the entry point and regulating the immunity of the host to resist pathogenic infections. Therefore, the method can eliminate the risk of drug-resistant bacteria. In addition, the small molecule compound can better protect the host in synergy with antibiotics, can shorten the use period of antibiotics and minimize the production of drug-resistant bacteria.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the use of small molecule compounds for improving the host's ability to clear pathogenic bacteria and the use in the preparation of anti-pathogenic bacteria infection drugs. Background technique [0002] At present, antibiotics are used for the treatment of Staphylococcus aureus infection, leading to the emergence of drug-resistant bacteria such as MRSA, which makes it embarrassing for antibiotics to treat drug-resistant bacterial infections, and the invention of new antibiotics cannot keep up with the speed of bacterial resistance. The disadvantages of using antibiotics to treat Staphylococcus aureus infection are, on the one hand, antibiotic-resistant bacteria are produced very quickly, resulting in no antibiotics available for later treatment of drug-resistant bacteria; on the other hand, the screening period for new antibiotics is very long and the cost is high. At the same time,...

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the problems of using antibiotics to treat pathogenic bacteria infection, which will produce drug-resistant bacteria and the screening cycle of new antibiotics is long, etc., using metabolomics technology to screen anti-infection small molecules from the serum of infected mice, and screening out the anti-infection small molecules that can improve The ability and resistance of the host to pathogenic bacteria, and small molecular metabolites that reduce the content of pathogenic bacteria in the host, thereby providing a use of the screened small molecule compound for improving the ability of the host to clear pathogenic bacteria, and the screened small molecule Application of molecular compound in preparation of anti-pathogen infection medicine

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