Cluster magnetic control micro robot imitating inner structure of magnetic drive bacteria and preparation method and application thereof

A technology of micro-robots and internal structures, applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., to achieve precise trajectory control of athletic ability, huge application value, and superior athletic ability.

Pending Publication Date: 2020-10-13
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biomimetic structure of magnetotactic bacteria needs to control the assembly process of magnetic nanoparticles at the micron level, but this assembly process has not been reported; on the other hand,

Method used

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  • Cluster magnetic control micro robot imitating inner structure of magnetic drive bacteria and preparation method and application thereof
  • Cluster magnetic control micro robot imitating inner structure of magnetic drive bacteria and preparation method and application thereof
  • Cluster magnetic control micro robot imitating inner structure of magnetic drive bacteria and preparation method and application thereof

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Embodiment 1

[0038] In the present invention, the soft micro-robot imitating the internal drive structure of the magnetotactic bacteria of the novel cluster magnetic control, its preparation and application methods are as follows:

[0039] (1) Preparation of magnetic nanomaterials:

[0040] (1) 0.68g of FeCl 3 ·6H 2 O, the NaAc of 1.8g and the polyethyleneimine of 0.5g are dissolved in the ethylene glycol of 20mL, place reaction kettle after dissolving;

[0041] (2) After reacting at 120° C. for 12 hours, wash with deionized water for three times, and finally disperse in deionized water to obtain the above-mentioned magnetic nanomaterial for assembling imitation magnetic repelling bacteria.

[0042] (2) Preparation of soft micro-robot imitating the internal structure of magnetotactic bacteria:

[0043] (1) Disperse the above-mentioned magnetic nanomaterials in deionized water, sonicate for 3 minutes, and dissolve 100.0 mg of polyethyleneimine and 222.0 mg of polyethylene glycol in 537 μ...

Embodiment 2

[0057] In this embodiment, the soft micro-robot imitating the internal drive structure of the magnetotactic bacteria of the new cluster magnetic control, its preparation and application methods are as follows:

[0058] (1) Preparation of magnetic nanomaterials:

[0059] (1) 0.68g of FeCl 3 ·6H 2 O, the NaAc of 1.8g and the polyethyleneimine of 0.5g are dissolved in the ethylene glycol of 20mL, place reaction kettle after dissolving;

[0060] (2) After reacting at 120° C. for 12 hours, wash with deionized water for three times, and finally disperse in deionized water to obtain the above-mentioned magnetic nanomaterial for assembling imitation magnetic repelling bacteria.

[0061] (2) Preparation of soft micro-robot imitating the internal structure of magnetotactic bacteria:

[0062] (1) Disperse the above-mentioned magnetic nanomaterials in deionized water, sonicate for 3 minutes, and dissolve 50.0 mg of polyethyleneimine and 111.0 mg of polyethylene glycol in 269 μL of deio...

Embodiment 3

[0075] In this embodiment, the soft micro-robot imitating the internal drive structure of the magnetotactic bacteria of the new cluster magnetic control, its preparation and application methods are as follows:

[0076] (1) Preparation of magnetic nanomaterials:

[0077] (1) 0.68g of FeCl 3 ·6H 2 O, the NaAc of 1.8g and the polyethyleneimine of 0.5g are dissolved in the ethylene glycol of 20mL, place reaction kettle after dissolving;

[0078] (2) After reacting at 120° C. for 12 hours, wash with deionized water for three times, and finally disperse in deionized water to obtain the above-mentioned magnetic nanomaterial for assembling imitation magnetic repelling bacteria.

[0079] (2) Preparation of soft micro-robot imitating the internal structure of magnetotactic bacteria:

[0080] (1) Disperse the above-mentioned magnetic nanomaterials in deionized water, sonicate for 3 minutes, and dissolve 37.0 mg of polyethyleneimine and 83.0 mg of polyethylene glycol in 200 μL of deion...

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Abstract

The invention relates to a cluster magnetic control micro robot imitating the inner structure of magnetic drive bacteria and a preparation method and application thereof. By utilizing the characteristics of stable mechanical strength and non-swelling deformation of non-swelling hydrogel, an external magnetic field is applied to regulate and control the assembly behavior of magnetic nanoparticles in the microgel, and the magnetic nanoparticles are assembled into an orderly-arranged micron-sized magnetic drive unit structure, so that the small-sized control of the magnetic nanoparticles and thecontrol of the highly ordered structure of the magnetic nanoparticles are realized, and the micro robot imitating the inner structure of the magnetic drive bacteria is prepared. The prepared micro robot imitating the inner structure of the magnetic drive bacteria can be applied to targeted microvascular thrombolysis and targeted stem cell transportation. Compared with the prior art, the micro robot imitating the inner structure of the magnetic drive bacteria has a magnetic nanoparticle assembly body which is arranged in a linear shape like a magnetic body, and the micro robot with the drivingstructure has the advantages of excellent movement capability and accurate track control, and has good biocompatibility.

Description

technical field [0001] The invention relates to a micro-robot imitating the magneto-dispelling fungus, in particular to a micro-robot with a cluster magnetic control imitating the inner structure of the magneto-dispelling fungus and its preparation method and application. Background technique [0002] The structure size of the micro-swimming robot is small, the device is precise, and it can enter the narrow space that humans and macro-robots cannot reach to perform micro-manipulation, and the application prospect is very broad. [0003] It has been reported that micro-robots imitating microorganisms are limited to imitating the external structure. The biomimetic structure of magnetotactic bacteria needs to control the assembly process of magnetic nanoparticles at the micron level, but this assembly process has not been reported; on the other hand, the drive and motion control of micro-robots in a low Reynolds number environment is a difficult problem in exploring the microsc...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/58A61K47/32A61K47/10A61K9/06A61K45/00A61K35/12A61P7/02B82Y5/00
CPCA61K9/06A61K35/12A61K41/00A61K41/0052A61K45/00A61K47/10A61K47/32A61K47/58A61P7/02B82Y5/00
Inventor 何斌谢美华张薇
Owner TONGJI UNIV
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