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Novel fluoroossiol preparation and preparation method thereof

A fluorocalcitriol and a new technology are applied in the field of new fluorocalcitriol soft capsules for the treatment of osteoporosis and the field of preparation thereof, which can solve the problems of poor oral taste, poor patient compliance and the like, and achieve good chewability, Reduced disintegration time and enhanced stability

Inactive Publication Date: 2020-10-16
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing fluocautotriol preparations are mainly tablets, which have the problems of poor taste and poor patient compliance

Method used

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  • Novel fluoroossiol preparation and preparation method thereof
  • Novel fluoroossiol preparation and preparation method thereof
  • Novel fluoroossiol preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020]

[0021] Soft capsules were prepared according to the method in the summary of the invention.

Embodiment 2

[0023]

[0024] Soft capsules were prepared according to the method in the summary of the invention.

Embodiment 3

[0026]

[0027] Soft capsules were prepared according to the method in the summary of the invention.

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Abstract

The invention discloses a novel fluoroossiol preparation and a preparation method thereof, and particularly relates to the technical field of pharmaceutical preparations. The novel fluoroossiol preparation comprises soft capsule filling liquid and a soft capsule shell, wherein the filling liquid is prepared from fluoroossiol, refined vegetable oil, a buffering agent and a flavoring agent; and thecapsule shell is prepared from gelatin, a thickening agent, a flavoring agent, water and an opacifier. The fluoroossiol soft capsule filling liquid prepared by the preparation method disclosed by theinvention is stable in quality, the capsule shell cannot absorb water to be softened, the fluoroossiol soft capsule filling liquid can be chewed for taking, is used for treating osteoporosis, ricketsand the like, and is shortest in disintegration time, quick in effect and high in bioavailability, so that the fluoroossiol soft capsule disclosed by the invention is obviously superior to an existingproduct.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, more specifically, the invention relates to a novel flucracitriol soft capsule for treating osteoporosis and a preparation method thereof. Background technique [0002] Calcitriol is an analogue of vitamin D3 and a derivative of the active form of the small intestine. It plays a role by binding to receptors distributed in target tissues. This product can regulate calcium metabolism and resist rickets. It is used for the treatment of parathyroid function Hypoplasia. Existing calcitriol preparations are mainly tablets, and calcitriol tablets were jointly developed and marketed by Sumitomo and Taisho Pharmaceutical in Japan at the earliest in April 2001; they are not listed in other countries. [0003] The parathyroid glands are endocrine glands mostly located behind the lateral lobe of the thyroid gland in the front of the human neck. About 80% of people have four parathyroid g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/36A61K31/593A61P3/14A61P5/18
CPCA61K9/4808A61K9/4816A61K9/4825A61K31/593A61P3/14A61P5/18
Inventor 孙桂玉臧云龙陈阳生刘晓霞王明刚刘振玉方东兵朱锐李秀秀
Owner CP PHARMA QINGDAO CO LTD