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Targeted nanoparticle and preparation method, application and system thereof, equipment and storage medium

A nanoparticle, targeted technology, applied in pharmaceutical formulations, non-active ingredients medical preparations, wave energy or particle radiation treatment materials, etc., can solve the problems of difficult to penetrate the vascular barrier, low sensitivity, low efficiency, etc.

Active Publication Date: 2020-10-30
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Description
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Problems solved by technology

Among them, the efficiency of drug delivery through the EPR effect is very low, less than 0.7%, most of the drugs are captured by the endothelial network tissue of the liver or spleen, and the method of drug delivery through the EPR effect is still difficult to penetrate the vascular barrier; targeting at the tumor microenvironment Most of the targeted modification methods, such as pH-responsive and temperature-responsive methods, have low sensitivity and the uptake rate is still very low

Method used

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  • Targeted nanoparticle and preparation method, application and system thereof, equipment and storage medium
  • Targeted nanoparticle and preparation method, application and system thereof, equipment and storage medium
  • Targeted nanoparticle and preparation method, application and system thereof, equipment and storage medium

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preparation example Construction

[0105] The present invention also provides a method for preparing targeted nanoparticles, comprising the following steps:

[0106] S101: Mix the conjugated polymer, the amphiphilic polymer and the organic solvent to obtain a mixed liquid; wherein, the absorption wavelength of the conjugated polymer is 600nm-1700nm;

[0107] Wherein, the conjugated polymer and the amphiphilic polymer are as described above, and will not be repeated here. The organic solvent can be a conventional organic solvent in the field of nanomaterial preparation, which is not particularly limited here. Further, the organic solvent in step S101 The solvent is THF;

[0108] Further, the amphiphilic polymer is Lipid-PEG or DSPE-PEG, and the mass ratio of the conjugated polymer to the amphiphilic polymer is 1: (1.8-2.2);

[0109] Further, the amphiphilic polymer is PS-PEG-COOH, in the mixed solution, the concentration of the conjugated polymer is 45 μg / mL-55 μg / mL, and the concentration of the amphiphilic po...

Embodiment 11

[0169] The preparation method of the targeting nanomaterial of embodiment 1.1 is as follows:

[0170] Take SP1 (1mg) and DSPE-PEG 2000 (2mg) was dissolved in THF (1ml) to obtain a mixed solution; the mixed solution was added to 9mL deionized water under ultrasonic conditions, continued ultrasonication for 2min (ultrasonic output power was 75W), and placed in deionized water for dialysis for two days. To remove THF, and then filter with a 0.2 μm syringe filter to obtain a homogeneous suspension of targeting nanomaterials (SP1NPs) containing SP1 copolymers;

[0171] SP2 copolymer-targeted nanoparticles (SP2NPs) were prepared in the same way as SP1NPs, except that SP2 was used instead of SP1; SP3 copolymer-targeted nanoparticles (SP3NPs) were prepared in the same way as SP1NPs, except that The difference is that SP3 is used instead of SP1; the preparation method of SP4 copolymer targeting nanomaterials (SP4NPs) is basically the same as that of SP1NPs, the difference is that SP4 ...

Embodiment 12

[0174] Dissolve SP1 and PS-PEG-COOH in THF to obtain a mixed solution, and in the mixed solution, the concentration of SP1 is 50 μg / mL, and the concentration of PS-PEG-COOH is 10 μg / mL, and the mixed solution is sonicated, Obtain a uniform solution; under ultrasonic conditions, quickly mix 5mL of the above mixed solution with 10mL of ultrapure water, remove THF by rotary evaporation, and then filter the remaining liquid with a 0.2 μm syringe filter to obtain SP1 copolymer. Homogeneous suspension of targeted nanomaterials (SP1NPs);

[0175] SP2 copolymer-targeted nanoparticles (SP2NPs) were prepared in the same way as SP1NPs, except that SP2 was used instead of SP1; SP3 copolymer-targeted nanoparticles (SP3NPs) were prepared in the same way as SP1NPs, except that The difference is that SP3 is used instead of SP1; the preparation method of SP4 copolymer targeting nanomaterials (SP4NPs) is basically the same as that of SP1NPs, the difference is that SP4 is used instead of SP1.

...

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Abstract

The invention relates to a targeted nanoparticle and a preparation method, an application and a system thereof, equipment and a storage medium. The targeted nanoparticle comprises a conjugated polymerand an amphiphilic polymer coating the conjugated polymer, wherein the conjugated polymer has a structure shown as a formula (I), and the absorption wavelength of the conjugated polymer is 600nm-1700nm. With application of the conjugated polymer, the targeting property of the targeted nanomaterial can be improved then the medicine intake rate can be further improved; after the conjugated polymeris prepared into the targeted nanomaterial, a photoacoustic force effect can be generated under the assistance of near-infrared pulse laser so that a blood vessel barrier can be broken through, the defects of low delivery efficiency and low uptake rate of the traditional nano-drug are overcome, and a foundation is laid for realizing accurate delivery of the drug. In addition, the targeted nano-material can be matched with a photoacoustic microscope or other imaging methods so that the whole process that the targeted nano-material enters specific lesion tissues is monitored in real time.

Description

technical field [0001] The present invention relates to the technical field of drug delivery, in particular to targeted nanoparticle and its preparation method, application, system, equipment and storage medium. Background technique [0002] At present, the key to drug delivery research is how to break through the vascular barrier to reach the lesion tissue. The most typical vascular barrier is the blood-brain barrier. With the development of nanotechnology, due to its high safety, it is used in drug delivery research to achieve targeted drug delivery and avoid toxic side effects. Generally, nanomaterials include nanoliposomes, polymer nanovesicles, and nanoparticles. However, the delivery mechanism of these nanomaterials mainly relies on the EPR effect (ie enhanced penetration and retention effect), active targeting and tumor microenvironment targeting of nanomaterials. Among them, the efficiency of drug delivery through the EPR effect is very low, less than 0.7%, most of...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/34A61K41/00A61P35/00
CPCA61K9/5146A61K9/0009A61K41/00
Inventor 李凯奚磊吴长锋
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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