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Application of desloratadine in the preparation of anti-multidrug-resistant Acinetobacter baumannii preparations

A technology of Acinetobacter baumannii and desloratadine, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients and the like

Active Publication Date: 2021-08-06
MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on desloratadine against Acinetobacter baumannii is still in the blank stage

Method used

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  • Application of desloratadine in the preparation of anti-multidrug-resistant Acinetobacter baumannii preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 Desloratadine anti-multidrug-resistant Acinetobacter baumannii static action assay

[0038] 1. Materials

[0039] 1.1 Experimental strains

[0040] Three strains of Acinetobacter baumannii (AB1, AB2, AB3) isolated from the Microbiology Laboratory of Qilu Children's Hospital of Shandong University and three strains of Acinetobacter baumannii (AB11, AB12, AB13) isolated from Qianfoshan Hospital of Shandong Province, all of the above strains were Antibiotics resistant to aminoglycosides (gentamicin), carbapenems (meropenem) and quinolones (levofloxacin), all of which are multi-drug resistant Acinetobacter baumannii.

[0041] 1.2 Drugs and main reagents

[0042] Desloratadine (desloratadine), Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai);

[0043] Calcium-adjusted MH Broth Medium (CAMHB), Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0044] MHA agar medium, Qingdao High-tech Industrial Park Haibo Biotech...

Embodiment 2

[0068] Example 2 Desloratadine Anti-multidrug-resistant Acinetobacter baumannii Dynamic Action Determination

[0069] 1. Materials

[0070] 1.1 Drugs and main reagents

[0071] Desloratadine (desloratadine), Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai);

[0072] Calcium-adjusted MH Broth Medium (CAMHB), Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0073] MHA agar medium, Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0074] Normal saline, Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai);

[0075] 1.2 Experimental strains

[0076] A multidrug-resistant Acinetobacter baumannii strain AB11 isolated from Qianfoshan Hospital in Shandong Province.

[0077] 1.3 Instruments

[0078] Electronic balance (AUY120), SHIMADZU CORPORATION (Japan);

[0079] Bacteria collection ring, Huanyao Pharmaceutical Equipment Sales Co., Ltd. (Beijing, China);

[0080] McFarney Turbidimet...

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Abstract

The invention provides the application of desloratadine in preparing anti-multidrug-resistant Acinetobacter baumannii preparations. Acinetobacter baumannii, as an opportunistic pathogen with strong vitality, is a common pathogen of nosocomial infection. Because Acinetobacter baumannii is inherently resistant to common antibiotics, it is prone to drug resistance. The purpose of the present invention is to provide promising active substances for the development of multidrug-resistant Acinetobacter baumannii therapeutic drugs, and according to the research results of the present invention, desloratadine has a good inhibitory effect on multidrug-resistant Acinetobacter baumannii , is expected to be used as an active substance in the development of related antibacterial drugs.

Description

technical field [0001] The invention belongs to the technical field of antimicrobial drugs, and in particular relates to the application of desloratadine in preparing anti-multidrug-resistant Acinetobacter baumannii preparations. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Acinetobacter baumannii has become one of the most difficult pathogens for global health institutions. Due to the innate resistance of Acinetobacter baumannii to some commonly used antibiotics, coupled with the large number and widespread use of broad-spectrum antibiotics, it is difficult to The drug resistance is gradually increasing, and the strains of multidrug-resistant Acinetobacter baumannii (...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4545A61K45/06A61P31/04
CPCA61K31/4545A61K45/06A61P31/04A61K2300/00
Inventor 李秀云王艳欣盖中涛王世富张乐海
Owner MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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