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Preparation method of periplaneta americana polypeptide extract taking water as medium

A technology of Periplaneta americana, extract, applied in the field of preparation of Periplaneta americana polypeptide extract, can solve problems such as emulsification, achieve the effects of improving product quality, avoiding emulsification that is difficult to separate, and huge economic benefits

Active Publication Date: 2020-11-13
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The object of the present invention is to provide a kind of preparation method of the Periplaneta americana polypeptide extract using water as the medium, in order to solve the technical problem that emulsification occurs when using water as the extraction solvent

Method used

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  • Preparation method of periplaneta americana polypeptide extract taking water as medium
  • Preparation method of periplaneta americana polypeptide extract taking water as medium

Examples

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Embodiment 1

[0033] Take 5 kg of Periplaneta americana medicinal materials, add 5 kg of activated carbon (200-300 mesh, 300 mesh is specifically selected in this embodiment), freeze to -20 ° C, and pulverize with a pulverizer (keep the temperature of the material below 0 ° C during the pulverization process) to obtain pulverized materials (through a 80-mesh sieve, and obtain the under-sieve). 25 L of pure water was added to the pulverized material, and the pulverized material was dispersed in pure water to obtain a dispersion. Use a homogenizer to perform homogenate extraction at a speed of 10,000 rpm (maintain the temperature of the material at 0-10°C during the homogenization process), until the powder obtained after the pulverized material is homogenized reaches 200 mesh, and the extraction mixture (that is, the homogenized Dispersions). Centrifuge and filter twice, the first centrifugal speed is set to 8000rpm, the second centrifugal speed is set to 16000rpm, after centrifugal filtrat...

Embodiment 2

[0035] Take 20kg of Periplaneta americana medicinal materials, add 30kg of activated carbon (400~500 mesh, 500 mesh is specifically selected in this embodiment), freeze to -10°C, and pulverize into powder with a pulverizer (keep at -5°C during the pulverization process) to obtain pulverization Material (through 80-mesh sieve, take the undersieve to obtain). Add 200L of water to the pulverized material, mix to obtain a dispersion liquid, and use a homogenizer to perform homogenization and extraction at a speed of 10,000 rpm (keep at 0-10°C during the homogenization process), until the powder reaches 400 mesh, and an extraction mixture ( That is, the dispersion liquid after grinding treatment). The extraction mixture was centrifuged and filtered (rotating speed was set at 25000 rpm), and the liquid phase was taken to obtain a crude extract. Use activated carbon to degrease and deodorize the extract crude product twice (adding 6% activated carbon of Periplaneta americana medical...

Embodiment 3

[0037]Take 2 kg of Periplaneta americana medicinal materials, add 4 kg of activated carbon (400-500 mesh, 500 mesh is specifically selected in this embodiment), freeze to -20 ° C, grind into powder with a grinder (keep below -10 ° C during the grinding process), and obtain Pulverize the material (pass through a 200-mesh sieve and obtain the undersize). Add 20L of water to the pulverized material, mix to obtain a dispersion, and use a homogenizer to homogenize and extract at a speed of 10,000 rpm (keep at 0-10°C during the homogenization process), until the powder reaches 500 mesh, and obtain an extraction mixture ( That is, the dispersion liquid after grinding treatment). Centrifuge and filter the extraction mixture twice, the first rotation speed is set at 16000 rpm, the second rotation speed is set at 25000 rpm, and the liquid phase is taken to obtain the crude extract. Use activated carbon to degrease and deodorize the extract crude product twice (adding 4% activated carbo...

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Abstract

The invention belongs to the technical field of natural component extraction and preparation. The invention relates to a preparation method of periplaneta americana polypeptide extract, in particularto a preparation method of periplaneta americana polypeptide extract taking water as a medium, which sequentially comprises the following steps: mixing periplaneta americana medicinal raw materials with activated carbon powder, and pulverizing to obtain a pulverized material; dispersing the crushed material in water to obtain a dispersion liquid, and grinding the dispersion liquid to obtain an extracted mixture; and purifying and separating the periplaneta americana polypeptide extract from the extraction mixture. According to the method, water is used as a medium; the method has the advantages of avoiding of organic solvent residues, complete polypeptide extraction, low extraction cost, realization of adsorption of grease components by active carbon, avoiding of difficult separation caused by emulsification of an extract, guaranteeing of the process smoothness, removal of the fishy smell of the product through active carbon adsorption, improvement of the product quality, and good market application prospect and potential huge economic benefits.

Description

technical field [0001] The invention belongs to the technical field of extraction and preparation of natural components, and relates to a preparation method of a Periplaneta americana polypeptide extract, in particular to a preparation method of a Periplaneta americana polypeptide extract using water as a medium. Background technique [0002] Periplaneta americana, also known as cockroach, modern studies have shown that its main active ingredients are polypeptides and biological enzymes, which have obvious effects of promoting tissue repair and regeneration, anti-tumor and anti-hepatitis. The marketed drugs made of Periplaneta americana as the main raw material include Kangfuxin Liquid, Xinmailong, Ganlong Capsules, etc., which have produced good economic and social benefits. [0003] Periplaneta americana is an animal medicinal material rich in oil, from which polypeptides are generally prepared by degreasing with organic solvents (petroleum ether, n-hexane, etc.) and then ...

Claims

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Application Information

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IPC IPC(8): C07K1/14
CPCC07K1/145Y02A50/30
Inventor 刘录马晓霞王越函丁雄蒲世彪谭文红周志宏
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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