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Artificial blood vessel capable of simulating natural blood vessel to release electric signals, and preparation method thereof

An artificial blood vessel and electrical signal technology, applied in the field of bionic artificial blood vessels, can solve the problems of intimal hyperplasia and poor regeneration performance, and achieve the effects of promoting angiogenesis, inhibiting thrombus formation, and inhibiting intimal hyperplasia

Pending Publication Date: 2020-11-17
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We adjust the piezoelectricity and ferroelectricity of P(VDF-TrFE) by annealing temperature, the negative potential caused by the ferroelectricity of P(VDF-TrFE) has a significant anticoagulation effect, and the piezoelectricity released by its Stimulation significantly promotes vascular regeneration, which helps to solve the problems of existing small-caliber artificial blood vessels that are prone to thrombosis, intimal hyperplasia, and poor regeneration performance

Method used

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  • Artificial blood vessel capable of simulating natural blood vessel to release electric signals, and preparation method thereof
  • Artificial blood vessel capable of simulating natural blood vessel to release electric signals, and preparation method thereof
  • Artificial blood vessel capable of simulating natural blood vessel to release electric signals, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] This implementation case uses electrospinning technology to prepare artificial blood vessels that can release electrical signals, and adjusts the crystallinity, β-phase content and mechanical properties of small-caliber artificial blood vessels through annealing treatment, including the following steps:

[0041] Step 1. Weigh 4g of P(VDF-TrFE) powder and dissolve it in 10mL of dimethylformamide / acetone (volume ratio 3:2) mixed solvent, stir until completely dissolved and continue stirring for 4h to obtain P(VDF-TrFE) TrFE) solution;

[0042] Step 2. Let the 40w / v% P(VDF-TrFE) solution stand for 30min for defoaming treatment, then put it into a medical syringe with a 21#G needle, connect the needle to the electrode of the high-voltage power supply, and directly ground the other side A receiving rod with a diameter of 2mm is used as a collector; the receiving distance is 15cm; the flow rate is 1ml / h, the spinning time is 20min, and the humidity of the spinning environment...

Embodiment 2-3

[0045] The difference between Embodiment 2-3 and Embodiment 1 is that the annealing temperature is different, and the specific difference is as follows in Table 1:

[0046] Table 1 embodiment 1-3 parameter table

[0047] serial number Annealing temperature (℃) product code Example 1 90 PVT-A90 Example 2 100 PVT-A100 Example 3 110 PVT-A110

Embodiment 1-3

[0140] Examples 1-3, Comparative Examples 2, 6, and 7 The detection data of blood vessel grafts in animals are as follows (n=5):

[0141] Table 8 In vivo blood vessel graft detection data table

[0142]

[0143] From the above test data, it can be seen that:

[0144] 1. Due to the relatively strong negative potential on the inner cavity surface, Example 2-3 exhibited a good anticoagulant effect after implantation. The surface potential of Example 1 was slightly lower, and its anticoagulant effect was slightly worse. There is a small amount of thrombosis. Comparative example 2 has no ferroelectricity, only weak negative zeta potential caused by ionized carboxyl groups, the anticoagulant effect is the worst, and obvious thrombus appears after transplantation.

[0145] 2. Examples 1-3 have piezoelectric properties, and the piezoelectric stimulation released under dynamic conditions in the body can promote the proliferation of endothelial cells and smooth muscles. The piezoel...

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Abstract

The invention belongs to the field of bionic artificial blood vessels, and particularly relates to an artificial blood vessel capable of releasing electric signals, which is characterized in that a piezoelectric material P(VDF-TrFE) is used for constructing the artificial blood vessel; furthermore, the ferroelectricity and piezoelectricity of the P(VDF-TrFE) artificial blood vessel are regulated and controlled through annealing treatment; the ferroelectricity is shown as the negative potential of the inner cavity of the P(VDF-TrFE) artificial blood vessel; and the piezoelectricity is shown asfollows: the P(VDF-TrFE) artificial blood vessel deforms under the action of blood pressure change; and then, electric signals are released. The artificial blood vessel capable of releasing the electric signals in the invention has the beneficial effects of being capable of effectively inhibiting thrombosis, inhibiting intimal hyperplasia and promoting blood vessel regeneration.

Description

technical field [0001] The invention belongs to the field of bionic artificial blood vessels, in particular to an artificial blood vessel capable of simulating natural blood vessels to release electrical signals and a preparation method thereof. Background technique [0002] Many clinical diseases, such as severe coronary artery blockage, peripheral artery occlusion, and congenital heart disease, all need to be treated with small-caliber blood vessel (caliber<6mm) transplantation. According to statistics, in the United States alone, about 500,000 coronary artery bypass grafts, 446,000 arteriovenous fistulas, and more than 6,000 congenital heart disease vascular grafts are performed every year. The "China Cardiovascular Disease Report 2018" pointed out that the situation of cardiovascular diseases in my country is more serious. It is estimated that more than 1.2 million blood vessel transplants are required for coronary artery bypass grafting and arteriovenous fistula in m...

Claims

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Application Information

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IPC IPC(8): A61F2/06A61L27/50
CPCA61F2/06A61L27/50A61F2240/002
Inventor 王恺马腾志孔德领
Owner NANKAI UNIV
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