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Functional polypeptide, erythrocyte drug-loading system capable of being specifically bound with collagen and application of erythrocyte drug-loading system

A technology that specifically binds red blood cells, applied in the field of functional peptides, can solve the problems affecting the stability of red blood cell carriers and scaffold structure, and achieve the effects of reducing rapid loss, promoting differentiation, and improving exercise recovery.

Active Publication Date: 2020-11-24
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Abstract
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  • Application Information

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Problems solved by technology

[0006]Another method uses chemical crosslinkers to crosslink red blood cells to the scaffold, but this may affect the stability of the red blood cell carrier and the structure of the scaffold

Method used

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  • Functional polypeptide, erythrocyte drug-loading system capable of being specifically bound with collagen and application of erythrocyte drug-loading system
  • Functional polypeptide, erythrocyte drug-loading system capable of being specifically bound with collagen and application of erythrocyte drug-loading system
  • Functional polypeptide, erythrocyte drug-loading system capable of being specifically bound with collagen and application of erythrocyte drug-loading system

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Embodiment Construction

[0036] In view of the deficiencies in the prior art, the inventors of the present invention solved the problem of efficient connection between drug-loaded erythrocytes and collagen materials by introducing a functional polypeptide after long-term research and extensive practice. The functional polypeptide has dual functions of one end specifically binding to the surface of red blood cells and the other end specifically connecting to collagen (such as figure 1 shown). Through the co-incubation of functional polypeptides, drug-loaded red blood cells, and collagen materials, the drug-loaded red blood cells are anchored on the collagen material, and the local concentration of the drug at the injury site is maintained and slowly released.

[0037] The technical solution, its implementation process and principle will be further explained as follows.

[0038] One aspect of the embodiments of the present invention provides a functional polypeptide, which comprises a collagen-binding ...

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Abstract

The invention discloses a functional polypeptide, an erythrocyte drug-loading system capable of being specifically bound with collagen and application of the erythrocyte drug-loading system. The functional polypeptide comprises a collagen binding sequence and an erythrocyte binding peptide sequence connected with the collagen binding sequence. The functional polypeptide has an amino acid sequenceas shown in SEQ ID NO: 1. The erythrocyte drug-loading system capable of being specifically bound with the collagen comprises drug-loading erythrocytes and functional polypeptides specifically bound with the drug-loading erythrocytes. The constructed erythrocyte drug-loading system capable of being specifically bound with the collagen can effectively anchor drug-loading erythrocyte microspheres onthe collagen material, so that rapid loss of a drug after transplantation is reduced; the drug-loading system has the capability of realizing concentration maintenance and slow release capabilities of the drug at a local injury part, can prolong a half-life period of the drug, promote more neural stem cells to be differentiated into neurons, promote more axonal regeneration, and has the functionof promoting better movement recovery of spinal cord injuries.

Description

technical field [0001] The present invention specifically relates to a erythrocyte drug-carrying system capable of specifically binding collagen, in particular to a functional polypeptide, and the erythrocyte drug-carrying system capable of specifically binding collagen prepared by adding the functional polypeptide and its application. Background technique [0002] The combined use of biological scaffolds and drugs has been widely used in the treatment of spinal cord injuries. On the one hand, the biomaterial collagen scaffold can provide a structural support to fill the damaged cavity and provide a certain guiding effect for the growth of nerve axons. On the other hand, it can be combined with various drug molecules to more effectively improve or rebuild the local inhibitory microenvironment formed after spinal cord injury. [0003] Paclitaxel, a microtubule stabilizer, has a good promoting effect on the regeneration of nerve axons and the recovery of motor function at low...

Claims

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Application Information

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IPC IPC(8): C07K19/00A61K47/46A61K47/64
CPCC07K7/06A61K47/46A61K47/42C07K2319/33
Inventor 戴建武陈艳艳胡玲玲
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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