Effervescent gel dry powder preparation and preparation method thereof
A technology of effervescent gel dry powder and dry powder preparation, applied in the field of effervescent gel dry powder preparation and its preparation, which can solve the problems of poor taste, not easy to be widely used, and the gel is not freshly prepared, so as to improve the taste and smoothness Effect
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Embodiment 1
[0023] The above is only a specific implementation case of the present invention, and the scope of protection of the present invention is not limited thereto. Any skilled person familiar with the technology should modify or replace the present invention within the technical specifications described in the present invention. Within the protection scope of the present invention.
[0024] In the present embodiment, at first prepare the quick-swelling gel particle, the making process of the fast-swelling gel particle is as follows:
[0025] Put 500 grams of Carbomer 971P in a wet granulator pot, and heat Carbomer 971P with a 95-degree water bath through the interlayer of the pot. Under the stirring of the stirring paddle at 15 rpm, the temperature of Carbomer 971P will gradually rise. When the temperature reaches 85-90 degrees, slowly pour 320 grams of polyethylene glycol 6000 (PEG6000) particles into the pot of the wet granulator. Then the speed of the stirring paddle is increas...
Embodiment 2
[0030] In this example, the fast-swelling gel granules are prepared first, and the production process of the fast-swelling gel granules is completely consistent with the preparation process of the fast-swelling gel granules described in Example 1.
[0031] Take 10 g of the quick-swelling gel particles prepared above, 10 g of active pharmaceutical ingredients, 3 g of foam-generating agent, 73 g of flavoring agent, 3 g of taste-masking agent, and 1 g of coloring agent. Fully mix to make 100g of the effervescent gel dry powder preparation of this embodiment. The specific compounds used in the active pharmaceutical ingredient, foaming agent, flavoring agent, taste-masking agent and coloring agent used in this embodiment are shown in Table 2 below.
[0032] Table 2
[0033]
[0034]
Embodiment 3
[0036] In this example, the fast-swelling gel granules are prepared first, and the production process of the fast-swelling gel granules is completely consistent with the preparation process of the fast-swelling gel granules described in Example 1.
[0037] Take 12g of the quick-swelling gel particles prepared above, 8g of active pharmaceutical ingredients, 4g of foam-generating agent, 72g of flavoring agent, 3g of taste-masking agent, and 1g of coloring agent. Fully mix to make 100g of the effervescent gel dry powder preparation of this embodiment. The specific compounds used in the active pharmaceutical ingredient, foaming agent, flavoring agent, taste-masking agent and coloring agent used in this embodiment are shown in Table 3 below.
[0038] table 3
[0039] Element specific compound active pharmaceutical ingredient Cefaclor Foaming agent sodium bicarbonate flavoring agent Xylitol Taste masking agent fruit flavor Colorant sun...
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