Effervescent gel dry powder preparation and preparation method thereof

A technology of effervescent gel dry powder and dry powder preparation, applied in the field of effervescent gel dry powder preparation and its preparation, which can solve the problems of poor taste, not easy to be widely used, and the gel is not freshly prepared, so as to improve the taste and smoothness Effect

Active Publication Date: 2020-12-04
NINGBO FOCUS BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the defects of gels in the current market, it is far from meeting the needs of infants and some patients with specia

Method used

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  • Effervescent gel dry powder preparation and preparation method thereof
  • Effervescent gel dry powder preparation and preparation method thereof
  • Effervescent gel dry powder preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The above is only a specific implementation case of the present invention, and the scope of protection of the present invention is not limited thereto. Any skilled person familiar with the technology should modify or replace the present invention within the technical specifications described in the present invention. Within the protection scope of the present invention.

[0024] In the present embodiment, at first prepare the quick-swelling gel particle, the making process of the fast-swelling gel particle is as follows:

[0025] Put 500 grams of Carbomer 971P in a wet granulator pot, and heat Carbomer 971P with a 95-degree water bath through the interlayer of the pot. Under the stirring of the stirring paddle at 15 rpm, the temperature of Carbomer 971P will gradually rise. When the temperature reaches 85-90 degrees, slowly pour 320 grams of polyethylene glycol 6000 (PEG6000) particles into the pot of the wet granulator. Then the speed of the stirring paddle is increas...

Embodiment 2

[0030] In this example, the fast-swelling gel granules are prepared first, and the production process of the fast-swelling gel granules is completely consistent with the preparation process of the fast-swelling gel granules described in Example 1.

[0031] Take 10 g of the quick-swelling gel particles prepared above, 10 g of active pharmaceutical ingredients, 3 g of foam-generating agent, 73 g of flavoring agent, 3 g of taste-masking agent, and 1 g of coloring agent. Fully mix to make 100g of the effervescent gel dry powder preparation of this embodiment. The specific compounds used in the active pharmaceutical ingredient, foaming agent, flavoring agent, taste-masking agent and coloring agent used in this embodiment are shown in Table 2 below.

[0032] Table 2

[0033]

[0034]

Embodiment 3

[0036] In this example, the fast-swelling gel granules are prepared first, and the production process of the fast-swelling gel granules is completely consistent with the preparation process of the fast-swelling gel granules described in Example 1.

[0037] Take 12g of the quick-swelling gel particles prepared above, 8g of active pharmaceutical ingredients, 4g of foam-generating agent, 72g of flavoring agent, 3g of taste-masking agent, and 1g of coloring agent. Fully mix to make 100g of the effervescent gel dry powder preparation of this embodiment. The specific compounds used in the active pharmaceutical ingredient, foaming agent, flavoring agent, taste-masking agent and coloring agent used in this embodiment are shown in Table 3 below.

[0038] table 3

[0039] Element specific compound active pharmaceutical ingredient Cefaclor Foaming agent sodium bicarbonate flavoring agent Xylitol Taste masking agent fruit flavor Colorant sun...

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Abstract

The invention relates to a novel oral preparation platform, namely an Effervescent gel EG preparation. The Effervescent gel EG preparation mainly comprises a quick-swelling gel, a foaming agent, an active ingredient and an auxiliary ingredient. The Effervescent gel EG preparation is mixed with a proper amount of water or aqueous solution, can be quickly (generally less than 30 seconds) swelled andform uniform multi-foam hydrogel. The preparation has the characteristics of quick gelling, convenience in preparation, uniform gel, smooth mouthfeel and adjustable viscosity, and is particularly suitable for children, old people and patients with swallowing reflex dysfunction. The oral Effervescent gel EG preparation has convenience, safety and excellent mouthfeel, obviously improves the compliance of children patients, and can be applied to the fields of medicaments, foods, health-care products and the like.

Description

technical field [0001] The invention relates to an oral preparation for medicine, food and health products, in particular to an effervescent gel dry powder preparation and a preparation method thereof. Background technique [0002] Oral preparations generally include tablets, capsules, suspensions, granules, solutions, syrups and gels, etc. For infants and some patients with special swallowing reflex dysfunction, because of their age, health or illness, swallowing reflex disorder, in the process of swallowing, it is easy to aspirate, take liquid or solid orally Inhalation of substances into the trachea can cause aspiration pneumonia or suffocation or even death. Therefore, the most suitable oral dosage form for them is a gel with a certain viscosity and adjustable viscosity. A certain viscosity can make the gel adhere to the oral cavity and pharyngeal mucosa, and can only enter the esophagus by swallowing, so as to prevent aspiration into the trachea; a certain consistency...

Claims

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Application Information

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IPC IPC(8): A23L2/40A23L33/135A23L33/14A61K9/06A61K47/32A61K47/10A61K47/02A61K31/545A61P31/04
CPCA23L2/40A23L33/135A23L33/14A61K9/06A61K9/0053A61K9/0007A61K47/32A61K47/10A61K47/02A61K31/545A61P31/04A23V2002/00A23V2400/113A23V2400/175A23V2400/51A23V2200/04A23V2200/16A23V2200/226A23V2200/228A23V2200/30A23V2250/1614A23V2250/76A61K31/167A61K31/485A61K31/192A61K9/0095
Inventor 张秋野王岩松
Owner NINGBO FOCUS BIOMEDICAL TECH CO LTD
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