31 results about "Swallow reflex" patented technology

Methods and systems for monitoring, preventing and/or treating upper airway disorders such as apnea, dysphagia, reflux and/or snoring are described. The methods and systems monitor the upper airway disorders by processing one or more neural signals obtained from one or more upper airway afferents. Upper airway disorders are prevented and/or treated by delivering one or more stimulations to one or more reflex-related afferents, efferents, muscles, and sensory receptors to manipulate the threshold and/or trigger an upper airway reflex including, but not limited to a swallow reflex and/or a negative-pressure reflex.

Compositions contain a therapeutically effective amount of tiglic aldehyde for at least one of provoking the swallowing reflex of dysphagic patients, decreasing appetite by delaying gastric emptying, reducing body weight gain, or reducing gylcemia by improving insulin sensitivity improving mood, memory or cognition. Methods are provided that include administering such compositions.

The invention provides compounds for use in a method of treating oral pharyngeal dysphagia in an individual and related products. One embodiment of the invention comprises administering to an individual an effective amount of a vanilloid receptor 1 (VR-1) agonist or high-affinity partial agonist to promote a swallow reflex.

The invention relates to a novel oral preparation platform, namely an Effervescent gel EG preparation. The Effervescent gel EG preparation mainly comprises a quick-swelling gel, a foaming agent, an active ingredient and an auxiliary ingredient. The Effervescent gel EG preparation is mixed with a proper amount of water or aqueous solution, can be quickly (generally less than 30 seconds) swelled andform uniform multi-foam hydrogel. The preparation has the characteristics of quick gelling, convenience in preparation, uniform gel, smooth mouthfeel and adjustable viscosity, and is particularly suitable for children, old people and patients with swallowing reflex dysfunction. The oral Effervescent gel EG preparation has convenience, safety and excellent mouthfeel, obviously improves the compliance of children patients, and can be applied to the fields of medicaments, foods, health-care products and the like.

The invention provides a handheld stroke recovery physiotherapy cold stimulation device which comprises a refrigeration system, a bendable heat conduction tube and a fixing shell. The refrigeration system comprises a cold collector, a thermoelectric cooler and a heat radiator, the fixing shell is provided with a sealed cavity, and the refrigeration system is encapsulated in the sealed cavity. Whenthe device works, a cold stimulation head is held in the mouth of a user. A cold end face of the thermoelectric cooler generates refrigeration effect which is transmitted to the cold stimulation headthrough the bendable heat conduction tube. The cold stimulation head conducts swallowing reflex stimulation on the user. The device improves preparation efficiency of cold stimulation.

The invention relates to a gastric tube for supplying or removing substances to or from the gastric tract of a patient, and to a method for introducing a gastric tube. In order to reduce the strain on the patient and the risk of injury, especially for patients with disturbed consciousness, the inventive gastric tube comprises a first tubular element (101, 201) which can be introduced into the gastric tract of a patient, forming a supply lumen (102) for substances to be supplied or removed to or from the gastric tract. Said first tubular element (101, 102) is formed from a skin-compatible and flexible material. The inventive gastric tube also comprises a second tubular element (108, 208) which is fixed to the first tubular element (101, 201) and provided with means for triggering the swallowing reflex of the patient, the second tubular element (108, 208) being more rigid than the first tubular element (101, 201).

Compositions comprise an amount of cinnamaldehyde that is orally tolerable, thus avoiding an unpleasant mouth feeling, and also tolerable in the gastrointestinal tract. The amount of cinnamaldehyde is supplemented by zinc, and the combination is effective to promote a swallowing reflex. The composition comprising the combination of cinnamaldehyde and zinc can be used in a method to treat dysphagia and/or prevent aspiration pneumonia from dysphagia. In an embodiment, the composition comprising cinnamaldehydeis administered to a human. The composition comprising cinnamaldehyde may be a medicament, a food product or a supplement to a food product.

Compositions contain a therapeutically effective amount of cuminaldehyde for at least one of provoking the swallowing reflex of dysphagic patients, decreasing appetite by delaying gastric emptying, reducing body weight gain, or reducing gylcemia by improving insulin sensitivity or improving mood, memory or cognition. Methods are provided that include administering such compositions.

Compositions contain a therapeutically effective amount of p-anisaldehyde for at least one of provoking the swallowing reflex of dysphagic patients, decreasing appetite by delaying gastric emptying, reducing body weight gain, or reducing gylcemia by improving insulin sensitivity, or improving mood, memory or cognition. Methods are provided that include administering such compositions.

The invention provides a method for treating dysphagia. The method comprises the following steps: inserting a catheter electrode into a pharyngeal cavity of a patient after disinfecting the catheter electrode; applying an electrical stimulation waveform causing swallowing reflex of a patient in the pharyngeal cavity of the patient through a catheter electrode, and forming the positive half cycle of the electrical stimulation waveform by combining square waves and triangular waves; and gradually enhancing the electrical stimulation intensity until the tolerance threshold value of the patient is triggered, and then repeatedly carrying out the next round of electrical stimulation on the pharyngeal cavity of the patient. The method has the beneficial effects that the current/voltage intensity required by using the electrical stimulation waveform is smaller, and the electrical stimulation waveform has enough pulse width duration time, so that the intensity for exciting nerves and muscles is smaller, and the application safety is more reliable.

A system and method of eliciting a swallowing reflex in a human subject. Stimulation signals are generated for eliciting a full swallowing reflex when applied to skin overlying a region of thyroid cartilage in the neck. The stimulation signals delivered via surface electrodes to the skin overlying at least the region of thyroid cartilage in the neck to elicit the full swallowing reflex in the human subject.

The invention discloses a method for relieving neurosurgery postoperative agitation under a sevoflurane general anesthesia condition. The method comprises steps as follows: intramuscular injection of 0.06 mg*kg<-1> of midazolam and 0.3 mg of scopolamine is performed on a patient 30 min before an operation, and the venous access is open after entrance; anesthesia induction: intravenous injection of 0.03 mg*kg<-1> of etomidate, 5 mu g*kg<-1> of fentanyl and 1 mg*kg<-1> of atracurium is performed on the patient; anesthesia maintenance: 3%-5% of sevoflurane is inhaled, the oxygen flow is 1.5 L/min, the concentration of sevoflurane is monitored by an anesthesia gas monitor, the MAC (minimum alveolar concentration) value is controlled within 1.3-1.5, continuous intravenous infusion of 2 mg*kg-1*h<-1> of propofol is performed, the blood pressure is controlled to be 20%-25% of the basic blood pressure, and discontinuous intravenous injection of atracurium is performed for maintaining muscular relaxation. During the operation, a Datex ECG monitor is adopted to perform routine monitoring of respiration and circulation functions, arterial blood gas analysis and electrolyte check are performed, and the homeostasis is maintained. Inhalation of sevoflurane is stopped 10 min before the operation is ended, and phlegm suction extubation is performed when autonomous respiration tidal volume is larger than 8 ml*kg-1, the blood oxygen saturation is larger than 95% and swallowing reflex recovers.

A composition for improving swallowing reflex failure characterized by comprising a substance P secretion promoter with an angiotensin convertase inhibitor or a substance P decomposition inhibitor and/or a dopamine secretion promoter; and a food and a drug for improving swallowing reflex failure which contain this composition.

Compositions can comprise the flavanol metabolite 3'-O-glucuronide epicatechin (3GEC). In some embodiments, the amount of 3GEC is effective to increase energy expenditure, sympathetic nervous system activity, and/or fat oxidation. Such a composition can be used in a method to support weight management or promote weight loss, a method for preventing obesity or overweight, and a method for treatingobesity or overweight. In some embodiments, the composition can improve insulin sensitivity, glucose tolerance, cognitive performance, cognition, mood and/or memory. In some embodiments, the composition can achieve a therapeutic effect selected from the group consisting of blood vessel dilation, reduced blood pressure, increased delivery of blood flow to tissues in the body, improvement of blood circulation, e.g. in brain, stimulation of protein synthesis, increased release of growth factors, enhanced immune function, and combinations thereof. In some embodiments, the composition can treat orprevent dysphagia, e.g., by provoking the swallowing reflex.