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Production process of ethyl bromodifluoroacetate

A technology of ethyl difluorobromoacetate and production process, applied in the field of chemistry, can solve problems such as increasing production costs, and achieve the effects of cost saving, speed control, and utilization rate improvement

Pending Publication Date: 2020-12-15
NANTONG BAOKAI CHEM
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  • Abstract
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  • Application Information

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Problems solved by technology

[0003] Now, there are many synthetic methods for ethyl difluorobromoacetate, but because some raw materials for the synthesis of ethyl difluorobromoacetate are rare or very industrially available, or require special instrument processing, the production cost is increased

Method used

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  • Production process of ethyl bromodifluoroacetate

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Embodiment

[0023] Such as figure 1 Shown, a kind of production technique of ethyl difluorobromoacetate comprises the steps:

[0024] Step 1. Bromination reaction: The bromine is metered and sucked into the bromination reaction kettle by vacuum, and vinylidene fluoride is used as a raw material to generate 1,1-difluoro-1,2 through light catalysis and bromine addition reaction, 2-Tribromoethane; the specific process is as follows: put vinylidene fluoride into a reaction bottle containing bromine, and add under light until the red color of the system fades to obtain 1,1-difluoro-1,2,2 - Tribromoethane, the content of 1,1-difluoro-1,2,2-tribromoethane is greater than 99%.

[0025] Step 2. Elimination reaction: Add the generated 1,1-difluoro-1,2,2-tribromoethane dropwise into a certain concentration of liquid caustic soda, and carry out the reaction of eliminating hydrogen bromide by raising the temperature to generate 1,1-difluoro -2,2-dibromoethylene; the specific process is as follows: W...

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Abstract

The invention discloses a production process of ethyl bromodifluoroacetate. The production process comprises the following steps: 1, bromination reaction; 2, elimination reaction; 3, oxidation reaction; 4, esterification reaction. Compared with other methods, the bromination addition reaction only needs to be carried out at normal pressure and under the catalysis of infrared light, so that the cost is saved compared with other catalysts, other impurities are not introduced, and the utilization rate of bromine is increased. The elimination reaction adopts a dropwise adding mode, so the reactionrate can be effectively controlled, and the flooding phenomenon which is easy to generate is avoided. The purity of the prepared finished product is greater than or equal to 99.0%, and the yield is greater than or equal to 80.0%.

Description

technical field [0001] The invention belongs to the field of chemistry, and in particular relates to a production process of ethyl difluorobromoacetate. Background technique [0002] As ethyl difluorobromoacetate is an important intermediate in organic synthesis. At present, difluoromethylene synthetic building blocks are commonly used to synthesize difluoromethylene-containing bioactive substances. Ethyl difluorobromoacetate is often used in bioactive molecules due to the introduction of ester groups and α-bromine atoms. The introduction of difluoromethylene into fluorine has been widely used in the synthesis of fluorine-containing bioactive substances, and has considerable research value. [0003] Now, there are many synthetic methods for ethyl difluorobromoacetate, but because some raw materials for the synthesis of ethyl difluorobromoacetate are rare or very industrially available, or require special instrument processing, the production cost is increased. Therefore, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/63C07C67/14
CPCC07C67/14C07C51/58C07C17/25C07C17/06
Inventor 闫宗刚茅嘉龙邹学明黄凯华王春雷周佳欢
Owner NANTONG BAOKAI CHEM
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