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Relevant prediction system for colorectal cancer, electronic equipment and storage medium

A prediction system and technology for colorectal cancer, applied in biochemical equipment and methods, microbiological determination/inspection, measuring devices, etc., can solve the problems that cannot be used as colorectal cancer screening and early diagnosis, lack of standardization, radiation exposure, etc.

Inactive Publication Date: 2020-12-15
韩书文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although colorectal cancer has made great progress in comprehensive treatment and MDT (multidisciplinary diagnosis and treatment model) in the past few years, the median PFS of most stage III and IV colorectal cancer is about 13-15 months, and OS ( overall survival) less than 3 years
However, these clinical and signs are often not easy to attract the attention of patients
(2) Imaging colonoscopy: ① Ordinary endoscopy is currently the most effective method for detecting asymptomatic precancerous polyps and colorectal cancer, but it needs to be cleaned first, and general anesthesia and invasive procedures expose patients to potential complications. serious complications; ②CT colonoscopy is an emerging non-invasive examination method, but it has defects such as radiation exposure, lack of standardization, and high false negative rate; ③Sigmoidoscopy can prevent a small number of proximal colon cancers, but protects the right The benefit of semi-colon cancer is low; ④ Capsule colonoscopy can complete endoscopic imaging without invasive operation, avoiding the risk of colonoscopy, but the requirements for bowel preparation are stricter than colonoscopy; (3) Serological examination: Such as tumor markers, Septin9 test, etc., have been used clinically, but the sensitivity is low
(4) Pathological examination: pathological biopsy report is the gold standard for the diagnosis of colorectal cancer, but the difficulty in obtaining materials prevents it from being used as a method for screening and early diagnosis of colorectal cancer
In summary, the current methods for predicting and early diagnosis of colorectal cancer are limited by various factors, and the risk assessment of colorectal cancer in healthy people has not yet been incorporated into clinical applications. Therefore, it is urgent to find new ways for early screening and risk assessment of colorectal cancer. Clinical Problems Solved

Method used

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  • Relevant prediction system for colorectal cancer, electronic equipment and storage medium
  • Relevant prediction system for colorectal cancer, electronic equipment and storage medium
  • Relevant prediction system for colorectal cancer, electronic equipment and storage medium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Please refer to figure 1 As shown, a colorectal cancer-related prediction system includes an acquisition unit 10 , an analysis unit 20 and a processing unit 30 . Among them: the collection unit 10 is used to collect and store the feces of relevant personnel, which is called a stool sample; the analysis unit 20 is used to analyze the feces and obtain an analysis sample, and the analysis sample includes microbial information and microbial metabolite information. One or more; the processing unit 30 is configured to construct a prediction model according to the analysis sample and the machine learning model, and obtain a prediction result according to the target sample and the prediction model, and the target sample is obtained by analyzing the feces of the target person sample.

[0094] Analyzing the microorganisms in feces (obtaining microbial information) or / and analyzing microbial metabolites (obtaining microbial metabolite information) can provide a corresponding asse...

Embodiment 2

[0105] Embodiment 2 is mainly aimed at the early screening model of high-risk groups, and its relevant personnel are high-risk groups, and the high-risk groups are one of those who are over 40 years old, have positive fecal occult blood, have a family history of intestinal cancer, and have a history of intestinal polyps or multiple; select multiple relevant persons (preferably diversification, that is, each high-risk group selects some people with bowel cancer and people without bowel cancer), and group the relevant people according to whether bowel cancer occurs ; Marking each relevant person with whether bowel cancer occurs, that is, setting a label for each relevant person's analysis sample, and the label is whether the relevant person corresponding to the analysis sample has bowel cancer.

[0106] The analysis samples corresponding to multiple relevant personnel are divided into training samples and test samples, and the machine learning model is trained and tested (the tra...

Embodiment 3

[0108] Embodiment 3 is mainly aimed at the risk prediction model of healthy people; its relevant personnel include healthy people, patients with a history of intestinal polyps and patients with early intestinal cancer.

[0109] Select a number of relevant personnel (preferably diverse, that is, healthy people, patients with a history of intestinal polyps, and early bowel cancer patients are selected), and group the relevant personnel according to whether bowel cancer occurs; Each relevant person is marked, that is, a label is set for the analysis sample of each relevant person, and the label is whether the relevant person corresponding to the analysis sample has bowel cancer.

[0110] The analysis samples corresponding to multiple relevant personnel are divided into training samples and test samples, and the machine learning model is trained and tested to finally obtain a risk prediction model; the target sample can be obtained by inputting the target sample into the risk predi...

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Abstract

The invention discloses a relevant prediction system for the colorectal cancer. The relevant prediction system comprises a collection unit, an analysis unit and a processing unit, wherein the collection unit is used for collecting and storing the faeces of relevant personnel, and the faeces can be called a faeces specimen; the analysis unit is used for analyzing the faeces to obtain an analysis sample, wherein the analysis sample comprises one or multiple of microorganism information and microorganism metabolite information; and the processing unit is used for constructing a prediction model according to the analysis sample and a machine learning model and obtaining a prediction result according to a target sample and the prediction model, wherein the target sample is a sample obtained byanalyzing the faeces of the relevant personnel. The invention also discloses electronic equipment and a computer storage medium. By use of the invention, through faeces analysis, relevant predictionsof the colorectal cancer can be obtained.

Description

technical field [0001] The invention relates to the technical field of colorectal cancer prediction, in particular to a colorectal cancer related prediction system, electronic equipment and storage medium. Background technique [0002] Colorectal cancer (CRC) is one of the most common clinical malignant tumors and one of the leading causes of cancer-related deaths. It is estimated that by 2030, there will be more than 2.2 million new cases worldwide, and the death cases to 1.1 million. The 5-year survival time of patients with early colorectal cancer is more than 40%, and the 5-year PFS (progression-free survival time) of patients reaches 22%. Although colorectal cancer has made great progress in comprehensive treatment and MDT (multidisciplinary diagnosis and treatment model) in the past few years, the median PFS of most stage III and IV colorectal cancer is about 13-15 months, and OS ( overall survival) was less than 3 years. Therefore, early screening and early predict...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12Q1/6895C12Q1/689C12Q1/6869G01N30/02G16B40/10G16B40/30G16B40/00
CPCC12Q1/6869C12Q1/6886C12Q1/689C12Q1/6895G01N30/02G16B40/00G16B40/10G16B40/30C12Q2531/113C12Q2565/125C12M1/00G06F17/00
Inventor 韩书文
Owner 韩书文
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