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Traditional Chinese medicine composition capable of improving meibomian gland functions

A meibomian gland and composition technology, which is applied in the direction of drug combination, drug delivery, and medical formula, can solve the problems of unsustainable effect, no drug effect, and difficulty in use, and achieve low price, wide range of indications, and safety high effect

Pending Publication Date: 2020-12-22
BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above methods either treat the symptoms but not the root cause, and the effect is not good; or they are expensive and difficult to use
Although there are currently attempts to treat MGD and the dry eye syndrome caused by fumigation, there are still many deficiencies, such as (1) only fumigation with saline or distilled water, no drug effect, and only temporary relief of symptoms; (2) Fumigation or hot compress of a large amount of traditional Chinese medicine soup for MGD does not cut into the pathogenesis of patients such as MGD, and the effect cannot last; (3) fumigation with proprietary medicines such as Houttuynia eye drops and other eye drops, because of lack of dialectics, the effect cannot last

Method used

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  • Traditional Chinese medicine composition capable of improving meibomian gland functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Formulate the formula according to the following composition:

[0033] 10g mulberry leaves, 10g mint leaves, 10g red peony, 10g saponins, 10g Kochia, 10g cnidium, 10g salvia;

[0034] Prepare the fumigation agent according to the following method, and carry out clinical treatment to the patient:

[0035] (1) Add water to the Chinese medicine composition of the prescription and boil it. The amount of water added is less than that of the medicinal materials, about 500ml. After boiling on high fire, turn to slow fire and cook for 40-45min. Keep the medicinal soup to obtain the fumigating agent, and store the medicinal residue separately;

[0036] (2) Pour the medicine soup into the fumigation device for eye fumigation, 15-30 minutes each time, 3-7 times a week, and treat continuously or intermittently according to the symptoms; specifically, add sterile water for injection into the ultrasonic nebulizer tank Above the scale line, add 20-30ml of the pre-cooked medicine soup...

Embodiment 2

[0039] A certain case: Luo XX, female, 31 years old. Diagnosis of binocular MGD, binocular dry eye syndrome.

[0040] At the first visit: OSDI (Ocular Surface Disease Index Questionnaire): 75 points; BUT (tear film break-up time) for both eyes: 2 seconds for the right eye, 3 seconds for the left eye; TMH (tear river height) for both eyes: 0.19mm for the right eye, Eye: 0.23mm; binocular Shirmer (tear secretion test): right eye: 2mm, left eye: 4mm.

[0041] Follow-up visit after 2 weeks of drug fumigation: OSDI (Ocular Surface Disease Index Questionnaire): 31 points; BUT (Tear Film Breakup Time) for both eyes: 6.68 seconds for the right eye, 6.54 seconds for the left eye; TMH (tear river height) for both eyes: Right eye: 0.22mm, left eye: 0.21mm; binocular Shirmer (tear secretion test): right eye: 7mm, left eye: 8mm.

Embodiment 3

[0043] A certain case: Zhao XX, female, 26 years old. Diagnosis of binocular MGD, binocular dry eye syndrome.

[0044] At the first visit: OSDI (Ocular Surface Disease Index Questionnaire): 45 points; BUT (tear film break-up time) for both eyes: 4 seconds for the right eye, 4 seconds for the left eye; TMH (tear river height) for both eyes: 0.19mm for the right eye, Eye: 0.17mm; binocular Shirmer (tear secretion test): right eye: 3mm, left eye: 4mm.

[0045]Follow-up visit after 2 weeks of drug fumigation: OSDI (Ocular Surface Disease Index Questionnaire): 23 points; BUT (Tear Film Breakup Time) for both eyes: 7.19 seconds for the right eye, 7.38 seconds for the left eye; TMH (tear river height) for both eyes: Right eye: 0.22mm, left eye: 0.27mm; binocular Shirmer (tear secretion test): right eye: 9mm, left eye: 9mm.

[0046] In order to better illustrate the therapeutic effect of the fumigation medicament of the present invention, the clinical application effect of the tradi...

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Abstract

The invention provides a traditional Chinese medicine composition capable of improving meibomian gland functions, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials: folium mori, mint leaves, radix paeoniae rubra, spina gleditsiae, fructus kochiae, fructus cnidii and radix salviae miltiorrhizae. The traditional Chinese medicine composition is subjected to heating water extraction and then separated to obtain medicine soup and medicine residues, the medicine soup can be used for fumigation, and themedicine residues can be used for warm compress. The traditional Chinese medicine composition has an exact clinical effect on diseases such as dry eyes caused by MGD, dry eye symptoms caused by videodisplay terminal syndrome (VDT) and meibomian gland cyst caused by meibomian gland dysfunction, does not have obvious use contraindication, complications or side effects, and is wide in indication range and high in safety.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for improving meibomian gland function and application thereof. Background technique [0002] Dry eye is a common external eye disease, which refers to the general term for a large class of diseases characterized by ocular surface tissue lesions due to abnormalities in tear quality and quantity or dynamics caused by various reasons. Keratoconjunctival xerosis. Common symptoms include dry eyes, easy fatigue, itchy eyes, foreign body sensation, burning sensation, sticky secretions, fear of wind, photophobia, and sensitivity to external stimuli; sometimes the eyes are too dry, and there is basically insufficient tear fluid, which stimulates the reflex In severe cases, the eyes will be red and swollen, congested, keratinized, and corneal epithelium is damaged and there are filaments adhered. This kind of damage can cause keratoco...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K36/65A61K9/00A61P27/02A61M11/00A61F9/00A61H35/02
CPCA61K36/605A61K36/534A61K36/71A61K36/65A61K36/483A61K36/185A61K36/234A61K36/537A61K9/0004A61K9/0014A61K9/0048A61P27/02A61M11/005A61F9/0008A61H35/02A61K2236/331A61K2300/00Y02A50/30
Inventor 接英于静邱礼新田磊杨珂朱蕾
Owner BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV