The invention discloses a thyroid nodule hard mass-softening detumescent preparation which is prepared mainly from raw medicinal materials of first components and second components in parts by weight: the first components comprising 3-6 parts of radix bupleuri, 3-9 parts of radix aristolochiae, 2-6 parts of prunella vulgaris, 8-15 parts of folium mahoniae, and 6-12 parts of white atractylodes rhizome; and the second components comprising 6-12 parts of kelp, 6-10 parts of seaweed, 6-15 parts of prepared cyperus rotundus, 3-12 parts of fructus aurantii, 5-10 parts of cuttlefish bone, 15-35 parts of raw oysters, 4-12 parts of sword beans, 4-12 parts of rhizoma sparganii, and 6-15 parts of forsythia. The selected materials are all traditional Chinese medicinal materials, and do not have any toxic and side effects; and drug sources are easy to get, the medicinal material costs are low, and no burden is caused to patients.