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Extraction and purification method of cannabidiol

A purification method, the technology of cannabidiol, applied in the field of purification, can solve problems such as environmental hazards, product safety impacts, solvents cannot be completely removed, and achieve the effect of simple operation

Active Publication Date: 2021-01-01
INST OF BAST FIBER CROPS CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of such organic solvents will cause harm to the environment, and the solvent residues in the final product cannot be removed, which will also affect product safety.

Method used

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  • Extraction and purification method of cannabidiol
  • Extraction and purification method of cannabidiol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The industrial hemp leaf material is crushed to 40 mesh, dried, weighed 100 grams, extracted in 100% ethanol, the extraction temperature is 60 ° C, the ratio of material to liquid is 1:5, the extract is collected after extraction once, and the residue is Add a new batch of solvent in the same amount as the previous one, repeat the extraction once, combine the extracts, remove the solvent from the extracts under reduced pressure, and place them in an oven at 105°C to dry to remove residual solvents. At this point the cannabidiol content in the extract was 10.1%.

[0054] The dried extract was washed with 5% sodium carbonate solution, the ratio of solid to liquid was 1:10, washed three times, and the precipitate was collected and dried in an oven at 105°C to remove residual solvent. The dried extract was dissolved in acetonitrile, an organic solvent, with a solid-to-liquid ratio of 1:10 (g / mL), dissolved five times, and the solutions were collected and combined five times...

Embodiment 2

[0058] The industrial hemp leaf material is crushed to 40 mesh, dried, weighed 100 grams, extracted in 100% ethanol, the extraction temperature is 60 ° C, the ratio of material to liquid is 1:5, the extract is collected after extraction once, and the residue is Add a new batch of solvent in the same amount as the previous one, repeat the extraction once, combine the extracts, remove the solvent from the extracts under reduced pressure, and place them in an oven at 105°C to dry to remove residual solvents. At this point the cannabidiol content in the extract was 12.1%.

[0059] The dried extract was washed with 15% sodium carbonate solution, the ratio of solid to liquid was 1:10, washed five times, and the precipitate was collected and dried in an oven at 105°C to remove residual solvent. The dried extract was dissolved in acetonitrile, an organic solvent, with a solid-to-liquid ratio of 1:10 (g / mL), dissolved five times, and the solutions were collected and combined five times...

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Abstract

The invention relates to the technical field of purification, in particular to an extraction and purification method of cannabidiol. The extraction and purification method comprises the following steps: crushing and drying industrial hemp leaves to obtain a dried material; extracting the dried material in ethanol or an ethanol-water solution, removing a solvent from the obtained extract solution,and drying to obtain an extraction extract; washing the extract with an acetic acid solution or a sodium carbonate solution, and drying the precipitate to obtain a dried extract; and dissolving the dried extract with ethanol or acetonitrile, adding PSA, activated carbon, C18 and magnesium sulfate into the solution, oscillating, centrifuging, removing the solvent, and drying. By adopting the extraction and purification method, the operation is simple, the CBD content can reach 40-58%, a plurality of prototype experiments can be carried out, original substances in a plurality of industrial cannabis sativa are reserved in the extraction process, and convenience can be brought to analysis of other functional components in the industrial cannabis sativa.

Description

technical field [0001] The invention relates to the technical field of purification, in particular to a method for extracting and purifying cannabidiol. Background technique [0002] Industrial hemp (Stevia rebaudiana Bertoni) is a plant of the Cannabis family and the genus Cannabis, which is widely distributed all over the world. Because cannabis contains a hallucinogenic and addictive secondary metabolite—tetrahydrocannabinol (THC), it has become one of the original drug plants well known to the public. In order to facilitate supervision and rational use, hemp varieties with a THC content of less than 0.3% are defined internationally as industrial hemp that does not have drug utilization value. Industrial hemp has tall plants, few branches, and high fiber content. Its economic value involves many aspects such as papermaking, textiles, building materials, food, and medicine. [0003] At present, more than 500 substances have been isolated from cannabis plants, including a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/82C07C39/23
CPCC07C37/004C07C37/82C07C2601/16C07C39/23Y02P20/54
Inventor 刘亮亮肖爱平冷鹃赵立宁廖丽萍张翠娥黎宇
Owner INST OF BAST FIBER CROPS CHINESE ACADEMY OF AGRI SCI
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