Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Apparatus and method for measuring the width of crystallization metastable zone in microscale flow system

A metastable zone, micro-scale technology, applied in the direction of measuring devices, material crystallization, test crystals, etc., can solve the problem of large micro-channel size, inability to measure the metastable zone of micro-scale flow system, and inability to solve the problem of measuring the width of crystal metastable zone, etc. problems, to achieve the effect of simple process control, easy to change operating conditions, and less raw material consumption

Active Publication Date: 2022-03-29
SICHUAN UNIV +1
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the conductivity measurement device in this method The size of the probe is too large compared to the microchannel, and it cannot be inserted into the microchannel for further investigation. row contact measurement , it is impossible to measure the metastable region of the micro-scale flow system
[0005] It can be seen that none of the methods for measuring the metastable zone in the prior art can solve the problem of measuring the width of the crystallized metastable zone in the flow system at the micro scale.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Apparatus and method for measuring the width of crystallization metastable zone in microscale flow system
  • Apparatus and method for measuring the width of crystallization metastable zone in microscale flow system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] In this embodiment, the microchannel 6 is a quartz glass tube with an inner diameter of 0.9 mm, an outer diameter of 1.5 mm, and a length of 23 cm. The device for measuring the width of the crystallization metastable zone in the microscale flow system is as follows: figure 1 As shown, it includes a temperature control system, a microscope 4 , a camera 5 , a computer 3 , and a syringe pump 2 . The temperature control system is composed of a constant temperature circulating water bath 10, a first thermal insulation jacket 7-1, a second thermal insulation jacket 7-2 and a temperature sensor 1. The length of the first thermal insulation jacket 7-1 is 17.5cm, and the suit In the section of the liquid inlet end of the microchannel, the second thermal insulation jacket 7-2 is set on the section of the liquid outlet end of the microchannel, and the spacing between the first thermal insulation jacket and the second thermal insulation jacket is 1 cm, and the spacing forms a micr...

Embodiment 2

[0034] In this example, the apparatus described in Example 1 is used to measure the width of the metastable zone when the potassium dihydrogen phosphate aqueous solution reaching saturation at 40° C. flows at a microscale.

[0035] According to the existing potassium dihydrogen phosphate solubility curve, dissolve 33.5g of potassium dihydrogen phosphate crystals (analytical pure) in 100g of deionized water to form an aqueous solution of potassium dihydrogen phosphate that reaches saturation at 40°C, and keep the temperature at 40°C spare.

[0036] The assay steps of the present embodiment are as follows:

[0037] (1) Fix the microchannel 6 equipped with the first thermal insulation jacket 7-1 and the second thermal insulation jacket 7-2 on the stage of the microscope 4, and make the microscope objective lens aim at the microchannel observation section, open and The camera 5 combined with the eyepiece of the microscope 4 observes the inside of the microchannel, and shoots the ...

Embodiment 3

[0042] In this example, the device described in Example 1 was used to measure the width of the metastable zone of the microscale flow system of the potassium dihydrogen phosphate aqueous solution reaching saturation at 40°C.

[0043] According to the existing potassium dihydrogen phosphate solubility curve, dissolve 33.5g of potassium dihydrogen phosphate crystals (analytical pure) in 100g of deionized water to form an aqueous solution of potassium dihydrogen phosphate that reaches saturation at 40°C, and keep the temperature at 40°C spare.

[0044] The assay steps of the present embodiment are as follows:

[0045] (1) Fix the microchannel 6 equipped with the first thermal insulation jacket 7-1 and the second thermal insulation jacket 7-2 on the stage of the microscope 4, and make the microscope objective lens aim at the microchannel observation section, open and The camera 5 combined with the eyepiece of the microscope 4 observes the inside of the microchannel, and shoots th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
lengthaaaaaaaaaa
Login to View More

Abstract

The device for measuring the width of the crystallization metastable zone of the micro-scale flow system of the present invention includes a temperature control system, a microscope, a camera, a computer and a syringe pump. The temperature control system consists of a constant temperature circulating water bath, a first heat preservation jacket, a second Composed of insulation jacket and temperature sensor. The method for measuring the width of the crystallization metastable zone of the micro-scale flow system of the present invention uses the above-mentioned measuring device to inject the tested solution whose temperature is the initial test temperature and reaches saturation at the initial test temperature into the microchannel at a constant flow rate through a syringe pump In this method, combined with the magnification effect of the microscope on the microchannel, the camera is used to take real-time pictures of the measured liquid in the microchannel to capture the crystallization state of the fluid, obtain the crystallization point temperature, and calculate the difference between the initial test temperature and the crystallization point temperature , the difference is the width of the crystallization metastable zone of the microscale flow system of the measured solution. The device and method of the present invention provide quantitative data analysis support for research on microchannel-crystal coupling technology.

Description

technical field [0001] The invention belongs to the field of crystallization data measurement, in particular to a device and method for measuring the width of a crystallization metastable zone in a microscale flow system. Background technique [0002] In the chemical and pharmaceutical industries, crystallization, as an effective separation and purification technology, is widely used in the preparation and purification of fine chemicals and biological products. In order to obtain crystal products with required quality indicators, industrial crystallization is generally operated in the crystallization metastable region. The so-called metastable zone refers to the region (range) between the solubility curve and the supersolubility curve of the solution system. The so-called solubility is the quality of the solute dissolved when a solid substance reaches saturation in 100g of solvent at a certain temperature. The so-called Supersolubility is the limit solubility of a solute at...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N25/14G01N21/84
CPCG01N25/147G01N25/145G01N21/84G01N2021/8477G01N2021/8411
Inventor 金央王逸夫任永胜李军李维贾连玉陈明
Owner SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com