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Plant-loaded active liposome for promoting hair regeneration and preparation method plant-loaded active liposome

A liposome and plant technology, applied in the direction of liposome delivery, plant raw materials, organic active ingredients, etc., to achieve the effects of shortening extraction and purification time, less loss, and high extraction efficiency

Inactive Publication Date: 2021-01-08
湖州中科院应用技术研究与产业化中心 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, if a variety of plant active substances are extracted from a plant or a variety of plant active substances are extracted from compound Chinese medicines, in the case of synergistically exerting the same therapeutic effect or health care effect, it is necessary to combine the different solubility properties and solubility When multiple active substances are contained in the same dosage form, how to solve the problem of drug loading of the active substance and the uniformity of the active substance in the dosage form are the difficulties that need to be overcome urgently

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] In this example, the prepared plant-loaded active liposomes were further used for the research on the therapeutic effect on mouse androgenetic alopecia: taking the mouse model of androgenetic alopecia as the research object, by externally applying plant-loaded active liposomes on the back of the mice Plastids were used to observe the hair growth of mice and detect the serum T, E2 content and T / E2 ratio to explore the therapeutic effect and related mechanism of plant-loaded active liposomes on androgenetic alopecia.

[0058] Specific steps: a. Number 56 B6CBAF1 / J male mice according to body weight, select 13 mice as the blank group according to the random number table method, and feed the remaining mice in separate cages. 5mg / Kg·d dose was administered to the back subcutaneously with testosterone propionate for 4 weeks to form an animal model of androgenetic alopecia, and the blank group was injected with the same amount of normal saline; b. After the mice were successful...

Embodiment 2

[0062] In this embodiment, the prepared plant-loaded active liposomes are further used to study the expression effects and therapeutic effects of VEGF and TGF-β1 in the skin lesions of androgenetic alopecia mice: taking the androgenetic alopecia mouse model as The purpose of the experiment is to study the expression of VEGF and TGF-β1 in its skin lesions, the therapeutic effect of plant-loaded active liposomes on androgenetic alopecia mice and the expression of VEGF and TGF-β1 after treatment, and to explore the effects of VEGF and TGF. The relevant role of -β1 in the pathogenesis of androgenetic alopecia and the effect of phytoactive liposomes on its expression level.

[0063] Steps: subcutaneously inject testosterone propionate on the back of the mouse to induce androgenetic alopecia animal models in the same way as in Example 1, and randomly group them into groups after successful modeling. At 12 weeks, the back skin lesions of the mice in each group were taken, made pathol...

Embodiment 3

[0067] In this embodiment, the prepared plant-loaded active liposomes are further used for the treatment of seborrheic alopecia.

[0068] Steps: 35 cases of male seborrheic alopecia patients in a second-class hospital conducted a 3-month clinical observation. During the treatment period, the left side of the scalp was treated with liposomes containing plant actives, and the right side of the scalp was treated with hair growth tincture. During the treatment period, the patients had monthly follow-up visits, filled out questionnaires and underwent trichoscopic examination. At the end of the experiment at the end of the third month, the patient's symptom self-score was used to analyze the satisfaction with the liposomes containing plant actives, and the therapeutic effect of the liposomes containing plant actives was analyzed through the hair count under the trichoscope and the improvement of scalp symptoms.

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Abstract

The invention discloses a plant-loaded active liposome for promoting hair regeneration and a preparation method of the plant-loaded active liposome. The plant-loaded active liposome comprises the following plant active components of volatile oil, phytoestrogen, oleanolic acid and quercetin. According to the preparation method, the plant-loaded active liposome is prepared by adopting a film dispersion method and a reversed-phase evaporation method in a compounding mode. The active matters are all derived from plant medicinal materials, can be transdermally administrated on scalp, realizes targeted administration, and is high in transdermal efficiency and good in alopecia treatment effect. According to the method, through an optimized process, large-dose loading of drugs with different complex components in small-particle liposome is realized, the preparation conditions are simple, the controllability is strong, the repeatability is high, and the application prospect is bright.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a plant-carrying active liposome for promoting hair regeneration and a preparation method thereof. Background technique [0002] Traditional Chinese medicine has been used in China for more than 3,000 years, and it has played a huge role in the survival and reproduction of the Chinese nation, disease treatment and health care. The theory of traditional Chinese medicine in my country believes that "the hair is blood, the kidneys are in the hair, and the yellow and white beard and hair are sparse. It is due to the deficiency of Qi and blood, which cannot nourish the hair, insufficient congenital endowment or excessive depletion of acquired essence, which leads to the loss of essence in the kidney. It is caused by unprosperous beard and hair. Just as it is said in "On the Causes and Symptoms of Various Diseases: Hair Diseases and Disorders": "The blo...

Claims

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Application Information

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IPC IPC(8): A61K36/638A61K9/127A61K47/28A61K47/24A61P17/14A61K31/56A61K31/352
CPCA61K9/0014A61K9/127A61K31/352A61K31/56A61K36/232A61K36/481A61K36/634A61K36/638A61K47/24A61K47/28A61K2236/35A61P17/14A61K2300/00
Inventor 邹灵龙刘有荣毛旭华
Owner 湖州中科院应用技术研究与产业化中心
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