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Traditional Chinese medicine compound preparation for treating rash caused by targeted medicine and preparation method

The technology of compound preparation and treatment target is applied in the field of traditional Chinese medicine compound preparation and preparation for treating skin rash caused by targeted drugs, and can solve the problems of poor efficacy of the treatment drug and unsuitability for large-scale use, and achieve the effect of relieving drug-induced skin rash.

Inactive Publication Date: 2021-01-08
JIANGYIN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, in view of the current situation that Western medicine only uses hormones and antibiotic ointments to treat rashes, and the existing therapeutic drugs have poor efficacy and are not suitable for large-scale use, it is necessary to seek a drug that is suitable for the treatment of rashes caused by targeted drugs. With many years of clinical application, it is necessary to have a traditional Chinese medicine compound preparation with definite curative effect, convenient use and mild adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A traditional Chinese medicine compound preparation for treating skin rashes caused by targeted drugs is prepared from the following raw materials by weight: 15 grams of Baibu, 15 grams of cocklebur, 10 grams of cloves, 10 grams of Passepartout, 10 grams of Lingxiaohua, 10 grams of Forsythia 10g, Sophora flavescens 15g, Honeycomb 10g, Tribulus terrestris 15g and Ophiopogon japonicus 30g.

[0028] A preparation method of a traditional Chinese medicine compound preparation for treating skin rash caused by a targeted drug, comprising the following steps:

[0029] 1) get 10 grams of public cloves and 10 grams of forsythia and put them in the extraction tank, pass into water vapor and distill it, and collect the volatile oil that is distilled, for subsequent use;

[0030] 2) Take 15 grams of Bai Bu, 15 grams of cocklebur, 10 grams of Passepartout, 10 grams of Ling Xiaohua, 15 grams of Sophora flavescens, 10 grams of honeycomb, 15 grams of Tribulus terrestris and 30 grams of ...

Embodiment 2

[0035] A traditional Chinese medicine compound preparation for treating skin rashes caused by targeted drugs is prepared from the following raw materials by weight: 15 grams of Baibu, 15 grams of cocklebur, 10 grams of cloves, 10 grams of Passepartout, 10 grams of Lingxiaohua, 10 grams of Forsythia 10g, Sophora flavescens 15g, Honeycomb 10g, Tribulus terrestris 15g and Ophiopogon japonicus 30g.

[0036] Another technical problem to be solved by the present invention is to provide a preparation method of a traditional Chinese medicine compound preparation for treating skin rash caused by targeted drugs, comprising the following steps:

[0037] 1) get 10 grams of public cloves and 10 grams of forsythia and put them in the extraction tank, pass into water vapor and distill it, and collect the volatile oil that is distilled, for subsequent use;

[0038] 2) Take 15 grams of Bai Bu, 15 grams of cocklebur, 10 grams of Passepartout, 10 grams of Ling Xiaohua, 15 grams of Sophora flaves...

experiment example 1

[0044] Experimental methods: A total of 60 patients with drug-induced rash caused by molecularly targeted drugs admitted to the Oncology Department of Jiangyin People's Hospital from March 2016 to March 2019 were randomly divided into a treatment group (n=30) and a control group (n=30). = 30), 30 cases in the control group were treated with conventional nursing methods, and antibiotic ointment was applied externally; 30 cases in the treatment group were rinsed with 400 ml of boiled water of the traditional Chinese medicine granules prepared in Example 1 of the present invention, cooled to below 40° C. and then applied to the skin rash and itching. , 3 times a day, 7 days as a course of treatment, the severity of rash and the incidence of infection in the two groups were observed.

[0045] After 7 days, the results in the treatment group were better than those in the control group, with a statistical difference (P<0.05). Conclusion For patients with drug-induced rash caused by ...

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Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating rash caused by a targeted drug. The traditional Chinese medicine compound preparation is prepared from the following raw materials by weight of15g of radix stemonae, 15g of fructus xanthii, 10g of flos caryophylli, 10g of fructus liquidambaris, 10g of flos campsis, 10g of fructus forsythiae, 15g of radix sophorae flavescentis, 10g of nidus vespae, 15g of fructus tribuli and 30g of radix ophiopogonis. The traditional Chinese medicine compound preparation solves the problems that at present, western medicineonly treats rash with hormones and antibiotic ointment, and existing treatment medicine is poor in curative effect, not suitable for large-area use and the like; and the traditional Chinese medicinecompound preparation is suitable for treating rash pruritus caused by targeted medicine, and has the advantages of being exact in curative effect, convenient to use, light in adverse reaction and widein market prospect through years of clinical application.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for treating skin rash caused by a targeted drug and a preparation method thereof. Background technique [0002] In the 21st century, when scientists were studying the pathogenesis of cancer, they found that by blocking cell signaling pathways or inhibiting new blood vessels from the molecular biology level, they could effectively control the growth and metastasis of tumor cells. Effect. With the increasing application of targeted drugs, the toxic and side effects of their treatment have also received widespread clinical attention. Among them, EGFR inhibitors are the most widely used clinically, including gefitinib and erlotinib. The incidence of rash was 41.4-71.9% and 38.9%, respectively. Traditional Chinese medicine believes that this disease belongs to the categories of "drug poison", "drug poison eruption" and "acne prickly heat". , Damp poison first stagnant in the s...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/16A61P17/00A61P17/04A61K35/64
CPCA61K9/16A61K35/64A61K36/185A61K36/28A61K36/489A61K36/61A61K36/634A61K36/8968A61K36/904A61K2236/331A61K2236/39A61K2236/51A61P17/00A61P17/04A61K2300/00
Inventor 奚蕾沈伟生张瑶吴春
Owner JIANGYIN PEOPLES HOSPITAL
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