Clindamycin phosphoric acid gel composition and preparation method thereof

A technology of clindamycin phosphate and gel composition, applied in the field of clindamycin phosphate gel composition and preparation thereof, can solve the problem that the stability does not reach the expected effect, the preservative must be added, and the aqueous solution is easy to Mildew and other problems, to achieve the effect of solving the short validity period, increasing the validity period and improving the validity period

Pending Publication Date: 2021-01-15
重庆健能医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As a hydrophilic gel material, carbomer has the advantages of non-toxicity and non-irritation. It can be used in transdermal preparations to obtain a uniform and stable system. It is one of the most commonly used hydrogel matrices at present. Mildew, need to add preservatives
The present invention selects carbomer gel as matrix, selects suitable preservatives to form a relatively stable preparation, but its stability does not reach the expected effect

Method used

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  • Clindamycin phosphoric acid gel composition and preparation method thereof
  • Clindamycin phosphoric acid gel composition and preparation method thereof
  • Clindamycin phosphoric acid gel composition and preparation method thereof

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Embodiment Construction

[0019] The present invention will be further described below in conjunction with specific experimental groups, but it should not be understood that the scope of the above subject of the present invention is limited to the following experimental groups. All technologies realized based on the above contents of the present invention belong to the scope of the present invention. The excipients in the following experimental groups can be replaced, or reduced or increased, with the same pharmaceutically acceptable excipients.

[0020] Experimental group 1

[0021] 1. Prescription

[0022]

[0023] 2. Process steps

[0024] 1) methylparaben and propylparaben of prescription quantity are dissolved in hot distilled water;

[0025] 2) Weigh the prescribed amount of Carbomer 980NF and add it into the above distilled water, stir at a low speed to make it dissolve completely to achieve the swelling effect;

[0026] 3) Add the prescribed amount of clindamycin phosphate, trehalose and...

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PUM

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Abstract

The invention provides a preparation composition of a clindamycin phosphate gel. The composition disclosed by the invention comprises the following ingredients: each 10g of clindamycin phosphate gel contains 0.05-0.15g of clindamycin phosphate, 0.1-0.2g of carbomer (980NF), 0.7-1.2g of glycerin, 0.005-0.01g of methylparaben, 0.005-0.01g of propylparaben, 0.005-0.2g of triethanolamine and 0.01-0.02g of trehalose. In the composition disclosed by the invention, each ingredient performs a synergistic effect, and the clindamycin phosphate gel which is finally prepared has higher stability.

Description

technical field [0001] The invention relates to a pharmaceutical preparation composition, in particular to a clindamycin phosphate gel composition and a preparation method thereof. Background technique [0002] Clindamycin was synthesized for the first time in 1966 by Magerlerin et al. who replaced the 7th hydroxyl group in the lincomycin molecule with chlorine. Clindamycin phosphate is a semi-synthetic derivative of clindamycin. It has no antibacterial activity in vitro, but it is fat-soluble, and it is easier to be absorbed through the skin than clindamycin. Antibacterial activity, the mechanism of action is to inhibit the early synthesis of bacterial proteins, thereby inhibiting Corynebacterium acnes and eliminating inflammation. [0003] Clindamycin phosphate is a chemically semi-synthesized clindamycin derivative. The clindamycin phosphate preparations currently on the market at home and abroad include external solution, gel, lotion, injection for injection, vaginal in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/7056A61K47/26A61P31/04A61P17/10
CPCA61K9/06A61K31/7056A61K47/26A61P17/10A61P31/04
Inventor 王雪叶世春李于林
Owner 重庆健能医药开发有限公司
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