Carotenoid compositions and uses thereof

Abstract

Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.

Description

[0001] Cross References to Related Applications

[0002] This application claims priority to U.S. Provisional Application No. 62 / 666,699, filed May 3, 2018, and U.S. Provisional Application No. 62 / 809,123, filed February 22, 2019, each of which is incorporated herein in its entirety. Background technique

[0003] Under normal circumstances, bacteria and associated toxins (endotoxemia) should not normally be found in the blood of healthy people. However, it is increasingly recognized that bacteria do enter the blood under certain conditions from sources such as the gut (leaky gut syndrome) or the gingival interface (mainly in patients with poor gum health). The consequence of this process, known as bacterial translocation, is a state of chronic bacteremia (bacteria) in the bloodstream. Bacterial translocation leads to chronic bacteremia, which excretes endotoxins, such as bacterial lipopolysaccharide (LPS), causing chronic low-grade chronic endotoxemia and the resulting chroni...

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