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Preparation method of phenylboronic acid-based glucose responsive sugar-sensitive microgel

A technology of sensitive microgel and glucose, which is applied in the field of preparation of glucose sensitive microgel, can solve the problems of hypoglycemia, endangering the life safety of patients, etc., and achieve the effect of simple preparation process

Inactive Publication Date: 2021-01-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional treatment for diabetes is insulin injection, but inaccurate injection dosage may cause hypoglycemia, etc., seriously endangering the life safety of patients

Method used

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  • Preparation method of phenylboronic acid-based glucose responsive sugar-sensitive microgel
  • Preparation method of phenylboronic acid-based glucose responsive sugar-sensitive microgel
  • Preparation method of phenylboronic acid-based glucose responsive sugar-sensitive microgel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Add 200.8 mg of AAPBA, 951.5 mg of NIPAM, 205 μL of DMAPAA, 17.3 mg of AIBN and 10.5 mL of anhydrous methanol into a three-neck flask equipped with a condenser tube, a magnet and an air guide tube, and bubble with argon for 30 minutes to remove the oxygen in the solution. Heat the solution to 60°C, react for 24 hours, concentrate the solution after the reaction, and precipitate the concentrated solution in 400 mL of ether, collect the white floc in the lower layer, precipitate three times, collect the white solid after suction filtration, and put it in a vacuum oven for drying The polymer (isopropylacrylamide-co-acrylamidophenylboronic acid-co-dimethylaminopropylacrylamide) P(NIPAM-co-AAPBA-co-DMAPAA) was obtained to constant weight.

[0032] Weigh 4106.6mg of Span 80 and dissolve it in 100mL of liquid paraffin, stir to make it evenly mixed, and divide it into two parts, one part is dripped with 5mL of 2wt% polymer (isopropylacrylamide-co-acrylamidophenylboronic acid -c...

Embodiment 2

[0034] Add 201.3 mg of AAPBA, 831.1 mg of NIPAM, 410 μL of DMAPAA, 17.4 mg of AIBN and 10.5 mL of anhydrous methanol into a three-necked flask equipped with a condenser tube, a magnet and an air guide tube, and bubble with argon for 30 minutes to remove the oxygen in the solution. Heat the solution to 60°C, react for 24 hours, concentrate the solution after the reaction, and precipitate the concentrated solution in 400 mL of ether, collect the white floc in the lower layer, precipitate three times, collect the white solid after suction filtration, and put it in a vacuum oven for drying The polymer (isopropylacrylamide-co-acrylamidophenylboronic acid-co-dimethylaminopropylacrylamide) P(NIPAM-co-AAPBA-co-DMAPAA) was obtained to constant weight.

[0035] Weigh 4103.5mg of Span 80 and dissolve it in 100mL of liquid paraffin, stir to mix evenly and divide it into two parts, one part is dripped with 5mL of 2 wt% polymer (isopropylacrylamide-co-acrylamidophenylboronic acid- co-dimeth...

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Abstract

The invention discloses a preparation method of phenylboronic acid-based glucose responsive sugar-sensitive microgel. The preparation method comprises the following steps: by using N-isopropylacrylamide, 3-acrylamide phenylboronic acid and N-dimethylaminopropylacrylamide as monomers and azodiisobutyronitrile as an initiator, synthesizing a polymer by adopting a free radical copolymerization method, and preparing glucose-responsive sugar-sensitive microgel from the obtained polymer and polyvinyl alcohol by adopting a reversed-phase microemulsion method. Raw materials and equipment used in the invention are available raw materials and equipment, the preparation process of the sugar-sensitive microgel is simple, and the obtained sugar-sensitive microgel can quickly respond to the change of glucose concentration in a physiological environment.

Description

technical field [0001] The invention belongs to the field of macromolecular materials and relates to a preparation method of a nanogel, in particular to a preparation method of a phenylboronic acid-based glucose-responsive sugar-sensitive microgel. Background technique [0002] Diabetes is one of the diseases that seriously affect human life and health in the world today. In 2017, the number of diabetic patients worldwide has reached 425 million. The traditional treatment for diabetes is insulin injection, but inaccurate injection dosage may cause hypoglycemia, etc., which seriously endangers the life safety of patients. Therefore, microgels that respond to changes in glucose concentration have attracted widespread attention. [0003] The results of in vitro tests showed that the volume of microgels changed regularly with the change of glucose concentration. By wrapping insulin in glucose-sensitive microgels, microgels that release different amounts of insulin and regulate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L33/24C08L29/04C08F220/54C08F230/06C08F220/60G01N27/327G01N27/48
CPCC08F220/54C08L29/04C08L33/24G01N27/3271G01N27/48C08F230/065C08F220/60
Inventor 俞豪杰王立王楠
Owner ZHEJIANG UNIV