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Cold heat-clearing granules and preparation method thereof

A cold-clearing and heat-clearing granule technology, which is applied in medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low solubility, easy moisture absorption and agglomeration of Ganmao Qingre granules, and achieve moisture-proof The effect is obvious, the solubility is improved, and the effect of reducing moisture absorption

Active Publication Date: 2021-01-29
DISHA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of low solubility and easy moisture absorption and caking of Ganmao Qingre granules, the present invention provides a preparation method of Ganmao Qingre granules with high solubility and moisture-proof effect through the compatibility of mannitol and sodium carboxymethyl cellulose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Take 200g of nepeta panicles, 60g of mint, 100g of fangfeng, 100g of bupleurum, 60g of perilla leaves, 100g of kudzu root, 60g of bellflower, 80g of bitter almond, 60g of angelica dahurica, 200g of kudiding, and 160g of reed rhizome.

[0016] Preparation:

[0017] Step 1. Weigh nepeta panicles, peppermint, and perilla leaves according to the prescription amount, add 4.8kg of water, heat and reflux for 4 hours to extract volatile oil. The distilled aqueous solution is collected in another device;

[0018] Step 2. Add 11.8 kg of water to decoct the dregs obtained in step 1 and the remaining eight-flavored medicinal materials such as Fangfeng for extraction twice, each time for 1.5 hours, combine the decoction, filter, and combine the filtrate with the aqueous solution collected in step 1. The combined solution is concentrated into an extract with a relative density of 1.32-1.35 (50°C);

[0019] Step 3. Take 400.0g of extract, add 480.0g of mannitol, 4.0g of s...

Embodiment 2

[0020] Example 2: Take 200g Nepeta panicle, 60g mint, 100g Fangfeng, 100g Bupleurum, 60g perilla leaf, 100g kudzu root, 60g bellflower, 80g bitter almond, 60g Angelica dahurica, 200g Kudiding, and 160g reed rhizome.

[0021] Preparation:

[0022] Step 1. Weigh nepeta panicles, peppermint, and perilla leaves according to the prescription amount, add 4.8kg of water, heat and reflux for 4 hours to extract volatile oil. The distilled aqueous solution is collected in another device;

[0023] Step 2. Add 11.8 kg of water to decoct the dregs obtained in step 1 and the remaining eight-flavored medicinal materials such as Fangfeng for extraction twice, each time for 1.5 hours, combine the decoction, filter, and combine the filtrate with the aqueous solution collected in step 1. The combined solution is concentrated into an extract with a relative density of 1.32-1.35 (50°C);

[0024] Step 3. Take 400.0g of extract, add 640.0g of mannitol, 4.0g of sodium carboxymethylcellulose, and 65...

Embodiment 3

[0025] Example 3: Take 200g of Schizonepeta ears, 60g of Mint, 100g of Fangfeng, 100g of Bupleurum, 60g of perilla leaves, 100g of Pueraria lobata, 60g of Platycodon grandiflorum, 80g of bitter almonds, 60g of Angelica dahurica, 200g of Kudiding, and 160g of reed rhizome.

[0026] Preparation:

[0027] Step 1. Weigh nepeta panicles, peppermint, and perilla leaves according to the prescription amount, add 4.8kg of water, heat and reflux for 4 hours to extract volatile oil. The distilled aqueous solution is collected in another device;

[0028] Step 2. Add 11.8 kg of water to decoct the dregs obtained in step 1 and the remaining eight-flavored medicinal materials such as Fangfeng for extraction twice, each time for 1.5 hours, combine the decoction, filter, and combine the filtrate with the aqueous solution collected in step 1. The combined solution is concentrated into an extract with a relative density of 1.32-1.35 (50°C);

[0029] Step 3. Take 400.0g of extract, add 640.0g o...

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PUM

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Abstract

The invention relates to a cold heat-clearing granules are prepared from 200 g of schizonepeta spike, 60 g of mint, 100 g of divaricate saposhnikovia root, 100 g of Chinese thorowax root, 60 g of perilla leaf, 100 g of root of kudzu vine, 60 g of balloonflower root, 80 g of bitter apricot seed, 60 g of dahurian angelica root, 200 g of bunge corydalis herb and 160 g of reed rhizome. The method is characterized by adding mannitol to a extract, which can improve the solubility of the cold heat-clearing granules, and the component is compatible with a small amount of sodium carboxymethyl cellulose, so that the cold heat-clearing granules can be effectively prevented from absorbing moisture and hardening. The invention provides the cold heat-clearing granules with stable quality.

Description

technical field [0001] The invention relates to a Ganmao Qingre granule with moisture-proof effect and a preparation method thereof, belonging to the technical field of preparation of traditional Chinese medicine compositions. Background technique [0002] Influenza is a clinically common disease and frequently-occurring disease. Its clinical manifestations are fever, headache, sneezing, sore throat, malaise, soreness and other symptoms. Ganmao Qingre Granule is a pure traditional Chinese medicine preparation, which is an effective clinical prescription for many years. It is made of eleven traditional Chinese medicines. It has the effect of dispelling wind and cold, relieving exterior heat and clearing heat. , Runny nose, cough and dry throat and other symptoms, take it in time at the beginning of a cold, the effect is remarkable. [0003] Ganmao Qingre Granules are mainly obtained by extracting volatile oil from Schizonepetae, peppermint, and perilla leaves, and preparing ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/16A61K47/38A61K47/26A61P11/00
CPCA61K36/538A61K36/534A61K36/238A61K36/233A61K36/535A61K36/488A61K36/346A61K36/736A61K36/232A61K36/66A61K36/899A61K9/1623A61K9/1652A61P11/00A61K2236/331A61K2236/51A61K2300/00
Inventor 秦利芳梁君孟庆举杨德斌
Owner DISHA PHARMA GRP