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Acetaminophen oral tablets and preparation method thereof

An acetaminophen oral tablet, a technology of acetaminophen, applied in the field of chemical medicine, can solve problems such as inability to break through rapid dissolution

Pending Publication Date: 2021-02-05
CHENGDU HENGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Ordinary sustained-release tablets are usually prepared by mechanical compression; after compression, the interior is fully filled, but some of the entire tablet needs sustained release, and some needs rapid release, so there is an internal and external layered preparation of tablets. method, but even for the immediate release part, the content of the disintegrant is only a little more, which is essentially the same as the traditional method, so it cannot break through the upper limit of rapid dissolution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Acetaminophen oral tablet, including: sustained-release part, regular-release part, and immediate-release part, all of which contain acetaminophen; the immediate-release part has unfilled voids in it.

[0030] Specifically, for the slow part, 350 mg of acetaminophen, 70 mg of hypromellose acetate succinate, and 7 mg of triethyl citrate. In hypromellose acetate succinate, it contains 20.0% methoxyl group, 15.2% hydroxypropoxyl group, 13.0% acetyl group and 13.0% succinate group.

[0031] Regular release part, acetaminophen 250mg, precrossified starch 50mg, hydroxypropyl cellulose 5mg, magnesium stearate 10mg.

[0032] For the immediate release part, paracetamol 50mg, Opadry gastric-soluble coating premix 50mg.

Embodiment 2

[0034] Acetaminophen oral tablet, including: sustained-release part, regular-release part, and immediate-release part, all of which contain acetaminophen; the immediate-release part has unfilled voids in it.

[0035] Specifically, the retarding part, acetaminophen 325mg, hypromellose acetate succinate 65mg, triethyl citrate 7mg; in hypromellose acetate succinate, methoxy 25.0 parts of hydroxypropoxy groups, 20.2 parts of hydroxypropoxy groups, 11.0 parts of acetyl groups, and 15.0 parts of succinyl groups.

[0036] Regular release part, acetaminophen 275mg, precrossified starch 55mg, hydroxypropyl cellulose 6mg, magnesium stearate 10mg;

[0037] For the immediate release part, paracetamol 50mg, Opadry gastric-soluble coating premix 50mg.

Embodiment 3

[0039] Acetaminophen oral tablet, including: sustained-release part, regular-release part, and immediate-release part, all of which contain acetaminophen; the immediate-release part has unfilled voids in it.

[0040] Specifically, for the slow part, 300 mg of acetaminophen, 60 mg of hypromellose acetate succinate, and 6 mg of triethyl citrate. The hypromellose acetate succinate contains 20.0 parts by weight of methoxy groups, 20.2 parts of hydroxypropoxy groups, 8.0 parts of acetyl groups and 20.0 parts of succinate groups.

[0041] Regular release part, acetaminophen 300mg, precrossified starch 60mg, hydroxypropyl cellulose 8mg, magnesium stearate 10mg.

[0042] For the immediate release part, paracetamol 50mg, Opadry gastric-soluble coating premix 50mg.

[0043] The present invention also provides, embodiment 1, embodiment 2 and embodiment 3 all use, and the steps are:

[0044] S1. Prepare the sustained-release part first, first mix ethanolaminophenol, hypromellose acetate...

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PUM

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Abstract

The invention relates to acetaminophen oral tablets. The oral tablets comprise the following components in parts by weight of a slow release part, a normal release part and a quick release part, and each of the three parts contains acetaminophen; and an unfilled gap is formed in the quick release part. The invention also discloses a preparation method of the acetaminophen oral tablets. The acetaminophen oral tablets have the beneficial effects that the release speed is high, the gap can be formed, and the required pressing force is small.

Description

technical field [0001] The invention relates to the field of chemical medicine, in particular to an acetaminophen oral tablet and a preparation method thereof. Background technique [0002] Acetaminophen is an in vivo metabolite of phenacetin, which has antipyretic and analgesic effects by inhibiting hypothalamic thermoregulation central prostaglandin synthase; it can reduce the synthesis and synthesis of prostaglandins PGE1, bradykinin and histamine, etc. freed. PGE1 mainly acts on the nerve center, and its reduction will lead to a decrease in the temperature setting point of the center, and the temperature receptors on the body surface will feel relatively hot, and then cause peripheral blood vessels to dilate and sweat through nerve regulation to achieve antipyretic effect, which inhibits the central nervous system The effect of prostaglandin synthesis is similar to that of aspirin, but the anti-inflammatory effect is weaker. No effect on platelets and coagulation mecha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/26A61K31/167A61K47/36A61K47/38A61P29/00
CPCA61K31/167A61K9/0056A61K9/2095A61K9/2054A61K9/2059A61P29/00
Inventor 朱德其沈桦刘辉肖仕远韩朋芩张宇李雪梅刘家俊
Owner CHENGDU HENGRUI PHARMA