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Bioscaffold compositions of matter

A bio-scaffold and composition technology, applied in the field of bio-scaffold compositions of substances, can solve problems such as undesired immunogenic responses

Pending Publication Date: 2021-02-19
爱惜康股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these conventional materials have several disadvantages, as they may cause undesired immunogenic responses in the patient (as in the case of ADM), do not provide sufficient support, protection and reinforcement to the dermis, and cannot Provides a robust cellular infiltration / remodeling response

Method used

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  • Bioscaffold compositions of matter
  • Bioscaffold compositions of matter
  • Bioscaffold compositions of matter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0116] Embodiment 1: the formation of biological scaffold

[0117] Natural or synthetic polymer constructs are fabricated using bioprinters such as the CellInk (Palo Alto, CA) or the RegenHU bioprinter (RegenHU, Switzerland). The bioprinter was set up to allow printing of polymers via a fused deposition modeling machine via a pneumatically driven injector, which would allow deposition of molten polymer ( figure 2 ). Polymer strands are pressure-deposited using a needle in a printed pattern to form pores, for example, 50-1000 microns, with an angular range of 10-90 degrees to form a variety of shapes or configurations ( figure 1 ).

[0118] Bioinks based on CoL-1 and Col-3 (Sigma Aldrich, MO or R&D Systems, MN) were similarly tandem (co-printed) or as sequential layers (as a coating or after polymer deposition for surface modification). sex) deposited in the structure ( image 3 ). Optionally, other bioactive molecules are added in the same manner, including but not li...

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PUM

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Abstract

The embodiments disclosed herein relate to acellular matrix bioscaffold compositions comprising 1) a natural or synthetic polymer; 2) collagen I (Col-1); and 3) collagen III (Col-3), wherein the ratioof Col-1 to Col-3 is between 0.5 and 3.5, wherein said bioscaffold is synthetic.

Description

[0001] Cross References to Related Applications [0002] This application is an international application claiming the benefit of priority to U.S. Provisional Application 62 / 668197, filed May 7, 2018, which is hereby incorporated by reference in its entirety. technical field [0003] Embodiments disclosed herein generally relate to compositions and materials for forming porous extracellular structures and / or bioscaffold structures that can be implanted in a patient. More specifically, there is a need for bioscaffold compositions and materials that minimize immunogenic responses in the host while providing a structural framework for tissue regeneration. Background technique [0004] Current surgical trends are towards bundled, minimally invasive, and ambulatory procedures, and thus patient and physician preferences continue to drive the adoption of lumpectomy and implant surgery for the treatment of breast and other cancers. Following resection of a mastectomy specimen, pat...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/52C08L71/02
CPCC08L71/02A61L27/48A61L27/3633A61L27/3683A61L27/56A61L2300/404A61L2300/426A61L27/24A61L27/18A61L2430/04B33Y80/00C08L89/06C08L67/04C08L89/00B33Y70/10A61L27/26A61L2300/42
Inventor H·J·托罗埃斯特莱拉O·H·加西亚
Owner 爱惜康股份有限公司
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