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A kind of anti-fatigue pharmaceutical composition and preparation method thereof
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A composition and anti-fatigue technology, applied in the field of biomedicine to achieve the effects of inhibiting oxidative stress, prolonging time and eliminating oxidative stress
Active Publication Date: 2022-06-21
THE CHINESE UNIVERSITY OF HONG KONG
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[0007] At present, there is no literature disclosing that the composition of astragalus, rehmannia glutinosa and Nansha ginseng has anti-fatigue effects and its application in anti-fatigue drugs
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preparation example Construction
[0042] A method for preparing an anti-fatigue pharmaceutical composition, using active ingredients and medically acceptable excipients to prepare the pharmaceutical composition, the active ingredients are the following raw materials in weight percentages: Astragalus 3-9 parts by weight, Nansha ginseng 3-9 parts by weight, Rehmannia glutinosa 3-9 parts by weight.
[0043] In a preferred embodiment, the preparation method of the pharmaceutical composition comprises the following steps:
[0044] (1) Weigh the raw materials according to the proportion, add ethanol with a mass percentage concentration of 60%, soak at room temperature for 24 hours, perform ultrasonic extraction for 1 hour, filter, and repeat the above extraction steps twice;
[0045] (2) Merge the filtrate three times, recover under reduced pressure, and freeze-dry to obtain extract fine powder;
[0046] (3) adding an appropriate amount of medically acceptable excipients, such as lactose, dextrin, starch, magnesium...
Embodiment 1
[0048] Embodiment 1. (tablet)
[0049] Get 1000g of the medicinal extract of the present invention, add 480g of lactose, 500g of starch and mix evenly, use 7% starchslurry 300g as a binder, wet granulate, dry, add 20g of magnesiumstearate and mix, and press into each tablet containing 10000 tablets of extract 100mg, each with a net weight of 0.2g. Take orally, 2 times a day, 3 tablets each time, for anti-fatigue. Symptoms: general fatigue, no improvement after rest.
Embodiment 2
[0050] Embodiment 2. (tablet)
[0051] Get 800g of the medicinal extract of the present invention, add 480g of lactose, 700g of starch and mix uniformly, use 7% starch slurry 300g as binder, wet granulate, dry, add 20g of magnesiumstearate and mix, and press into each tablet containing 10,000 tablets of extract 80mg, each with a net weight of 0.2g. Take orally, 2 times a day, 3 tablets each time, for anti-fatigue. Symptoms: general fatigue, no improvement after rest.
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Abstract
An anti-fatigue pharmaceutical composition and a preparation method thereof. The pharmaceutical composition includes active ingredients and medically acceptable excipients. The active ingredients are the following raw materials in weight percentages: Astragalus 3-9 weight parts, Nansha ginseng 3-9 parts by weight, 3-9 parts by weight of Rehmannia glutinosa. The pharmaceutical composition has anti-fatigue effect. In vivo pharmacological experiment results prove that the medicine of the present invention can significantly prolong the time of mice swimming under load, reduce the content of MDA in gastrocnemius muscle and liver tissue, increase the activity of SOD, CAT and GSH-Px and the content of glycogen in gastrocnemius muscle and liver tissue; In addition, it can also regulate the expression of Nrf2 and HO‑1 related proteins in mouse gastrocnemius muscle and liver tissues. The invention can be used to prepare the medicine for treating fatigue, and has the advantages of quick improvement of symptoms and short course of treatment as proved by experiments.
Description
technical field [0001] The invention relates to the technical field of biomedicine, in particular to an anti-fatigue pharmaceutical composition and a preparation method thereof. Background technique [0002] Fatigue is the inability of the body's physiological process to maintain its function at a specific level or the inability of an organ to maintain its predetermined exercise intensity. With the rapid development of society and the accelerated pace of life, long-term intense work, competitive pressure and emotional instability can easily lead to fatigue. Today, fatigue has become one of the main factors that endanger human health. If body fatigue is not eliminated in time, it will gradually accumulate and lead to emotional abnormalities. Over time, it will form chronic fatigue syndrome and even lead to death from overwork. Therefore, it is of great practical significance to study safe, effective and popular functional active products. [0003] Fatigue is the inability ...
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Application Information
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