A kind of anti-fatigue pharmaceutical composition and preparation method thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A composition and anti-fatigue technology, applied in the field of biomedicine to achieve the effects of inhibiting oxidative stress, prolonging time and eliminating oxidative stress
Active Publication Date: 2022-06-21
THE CHINESE UNIVERSITY OF HONG KONG
View PDF2 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0007] At present, there is no literature disclosing that the composition of astragalus, rehmannia glutinosa and Nansha ginseng has anti-fatigue effects and its application in anti-fatigue drugs
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
preparation example Construction
[0042] A method for preparing an anti-fatigue pharmaceutical composition, using active ingredients and medically acceptable excipients to prepare the pharmaceutical composition, the active ingredients are the following raw materials in weight percentages: Astragalus 3-9 parts by weight, Nansha ginseng 3-9 parts by weight, Rehmannia glutinosa 3-9 parts by weight.
[0043] In a preferred embodiment, the preparation method of the pharmaceutical composition comprises the following steps:
[0044] (1) Weigh the raw materials according to the proportion, add ethanol with a mass percentage concentration of 60%, soak at room temperature for 24 hours, perform ultrasonic extraction for 1 hour, filter, and repeat the above extraction steps twice;
[0045] (2) Merge the filtrate three times, recover under reduced pressure, and freeze-dry to obtain extract fine powder;
[0046] (3) adding an appropriate amount of medically acceptable excipients, such as lactose, dextrin, starch, magnesium...
Embodiment 1
[0048] Embodiment 1. (tablet)
[0049] Get 1000g of the medicinal extract of the present invention, add 480g of lactose, 500g of starch and mix evenly, use 7% starch slurry 300g as a binder, wet granulate, dry, add 20g of magnesium stearate and mix, and press into each tablet containing 10000 tablets of extract 100mg, each with a net weight of 0.2g. Take orally, 2 times a day, 3 tablets each time, for anti-fatigue. Symptoms: general fatigue, no improvement after rest.
Embodiment 2
[0050] Embodiment 2. (tablet)
[0051] Get 800g of the medicinal extract of the present invention, add 480g of lactose, 700g of starch and mix uniformly, use 7% starch slurry 300g as binder, wet granulate, dry, add 20g of magnesium stearate and mix, and press into each tablet containing 10,000 tablets of extract 80mg, each with a net weight of 0.2g. Take orally, 2 times a day, 3 tablets each time, for anti-fatigue. Symptoms: general fatigue, no improvement after rest.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
An anti-fatigue pharmaceutical composition and a preparation method thereof. The pharmaceutical composition includes active ingredients and medically acceptable excipients. The active ingredients are the following raw materials in weight percentages: Astragalus 3-9 weight parts, Nansha ginseng 3-9 parts by weight, 3-9 parts by weight of Rehmannia glutinosa. The pharmaceutical composition has anti-fatigue effect. In vivo pharmacological experiment results prove that the medicine of the present invention can significantly prolong the time of mice swimming under load, reduce the content of MDA in gastrocnemius muscle and liver tissue, increase the activity of SOD, CAT and GSH-Px and the content of glycogen in gastrocnemius muscle and liver tissue; In addition, it can also regulate the expression of Nrf2 and HO‑1 related proteins in mouse gastrocnemius muscle and liver tissues. The invention can be used to prepare the medicine for treating fatigue, and has the advantages of quick improvement of symptoms and short course of treatment as proved by experiments.
Description
technical field [0001] The invention relates to the technical field of biomedicine, in particular to an anti-fatigue pharmaceutical composition and a preparation method thereof. Background technique [0002] Fatigue is the inability of the body's physiological process to maintain its function at a specific level or the inability of an organ to maintain its predetermined exercise intensity. With the rapid development of society and the accelerated pace of life, long-term intense work, competitive pressure and emotional instability can easily lead to fatigue. Today, fatigue has become one of the main factors that endanger human health. If body fatigue is not eliminated in time, it will gradually accumulate and lead to emotional abnormalities. Over time, it will form chronic fatigue syndrome and even lead to death from overwork. Therefore, it is of great practical significance to study safe, effective and popular functional active products. [0003] Fatigue is the inability ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more