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Target area adjustable type batch animal ionizing radiation local irradiation fixing and shielding device and method thereof

A technology of immobilizing animals and ionizing radiation, which is applied in the field of basic medical research, can solve problems such as difficult position fixation, incomplete fixation, and difficult operation, etc., achieves simple fixation methods, solves compliance problems, and reduces the probability of impact Effect

Active Publication Date: 2021-02-26
THE NAVAL MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many defects in the previous similar devices, which are difficult to meet the needs of actual use. The main manifestations are: 1. Due to the poor compliance of the experimental animals themselves, it is difficult to maintain a fixed body position, and it needs to be effectively fixed.
The traditional method is intraperitoneal injection of chloral hydrate and other anesthesia. Although the basic anesthesia effect can be achieved, it is easy to overdose and cause accidental death of animals, and the injection of drugs has a potential impact on some detection indicators.
2 Regarding the fixation method, the traditional methods include clamping type and hole type, etc. The former is to clamp the main joints of the animal with clips, which can easily affect the blood supply, cause ischemia-reperfusion injury or even peripheral circulation is not smooth and other secondary injuries ;The latter can only fix animals of a specific size and shape, and the fixation is not complete, easy to loosen, and difficult to operate
4 When the small animal X-ray radiotherapy apparatus is used together with collimators and other devices for positioning irradiation, only one individual can be operated at a time
At present, similar products are unable to achieve large-scale, scalable and precise regional irradiation
Because the space and time of the irradiation site are precious, and the long waiting time will also increase the interference to the experiment, therefore, the research and manufacture of batch irradiation devices can greatly improve the experimental efficiency and experimental accuracy

Method used

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  • Target area adjustable type batch animal ionizing radiation local irradiation fixing and shielding device and method thereof
  • Target area adjustable type batch animal ionizing radiation local irradiation fixing and shielding device and method thereof
  • Target area adjustable type batch animal ionizing radiation local irradiation fixing and shielding device and method thereof

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Embodiment Construction

[0046] The present invention will be further described below in conjunction with the accompanying drawings.

[0047] This device intends to provide a fixed shielding device for batch animal ionizing radiation local irradiation with adjustable target area, which is suitable for any rectangular area (including size and position) of animals when carrying out batch animal partial irradiation experiments in what can be regarded as a parallel direction ray field. The ionizing radiation exposure (photon radiation and charged particles, etc.) is shielded. The main principles are continuous and safe anesthesia of batch experimental animals, spatial position positioning and body position fixation, and flexible and precise adjustment of the irradiation field. The specific principles are as follows:

[0048] For the shielding of ionizing rays such as gamma rays, its calculation should follow the following formula:

[0049]

[0050] In the formula, μ is the linear attenuation coefficien...

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Abstract

The invention discloses a target area adjustable type batch animal ionizing radiation local irradiation fixing and shielding device. The device comprises an animal fixing part and a ray shielding part, wherein the animal fixing part comprises an animal anesthesia fixing table, and the ray shielding part comprises a ray shielding table; an anesthesia induction box and a batch animal fixing box arearranged on the table top of the animal anesthesia fixing table; a transverse adjusting and controlling shielding device, an up-down adjusting and controlling shielding device and a transverse-longitudinal scale division plate are arranged on the table top of the ray shielding table; the transverse adjusting and controlling shielding device blocks redundant rays in the horizontal direction, and afirst gap with the adjustable size and position in the direction perpendicular to the ground is exposed; the up-down adjusting and controlling shielding device blocks redundant rays in the direction parallel to the ground, and a second gap with the adjustable size and position in the direction parallel to the ground is exposed; a rectangular area, namely an irradiation field, is formed at the intersection of the two gaps; through stepped connection, leakage caused when the rays pass through the transverse arrangement position of a shielding block is blocked, and incomplete blocking is avoided;and the position and area of the irradiation area are flexible, adjustable and accurate in irradiation.

Description

technical field [0001] The invention belongs to the field of basic medical scientific research, and in particular relates to a fixed shielding device and a method thereof for local irradiation of batches of animal ionizing radiation with adjustable target areas. Background technique [0002] Ionizing radiation is playing an increasingly important role in human production and life. It is widely used in medical treatment (such as tumor radiotherapy, medical imaging, etc.), industrial flaw detection, agricultural breeding, nuclear power plants, and national defense and military industries (such as nuclear weapons), etc., bringing great benefits to the national economy. Development has brought a huge boost. However, if these widespread nuclear and radiation devices are mismanaged and misoperated, they will cause various types of damage to the human body; and in the process of clinically using ionizing radiation to diagnose and treat diseases, how to maximize the therapeutic effe...

Claims

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Application Information

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IPC IPC(8): A61N5/10A61D3/00A61D7/04
CPCA61N5/10A61D3/00A61D7/04A61N2005/1094A61N2005/1097A61N2005/1087
Inventor 郭佳铭李百龙刘入菱刘虎高福崔建国孙顶赵庆伟张剑铎张瀚中
Owner THE NAVAL MEDICAL UNIV OF PLA
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