Solution sample processing device, equipment and system and application thereof
A solution sample and solution technology, applied in the preparation of test samples, biochemical equipment and methods, biomass post-processing, etc., can solve the problems of poor specificity, high energy and low throughput, etc.
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Embodiment 1
[0065] Embodiment 1 solution sample mixing and enrichment device
[0066] This embodiment provides an exemplary solution sample mixing and enrichment device of the present invention. figure 1 It is a schematic diagram and a structural diagram of an exemplary solution sample mixing and enrichment device of the present invention.
[0067] in, figure 1 (A) is a schematic diagram of the solution sample mixing and enrichment device. The device includes a cavity that can contain a solution, and can have inlets and outlets for the solution (not shown). The wall of the cavity is made of polytetrafluoroethylene material which is biocompatible to cells or biomacromolecules such as nucleic acid and protein. exist figure 1 The bottom and top of the device shown are respectively provided with two ultra-high frequency bulk acoustic wave resonators, and the two ultra-high frequency bulk acoustic wave resonators can generate ultra-high frequency in the solution in the cavity whose propaga...
Embodiment 2
[0083] In the method and device of the present invention, the ultra-high-frequency bulk acoustic wave resonator emits ultra-high-frequency bulk acoustic waves to the opposite side in the solution of the cavity, so that an acoustic vortex appears in the solution; the force on the particles in the solution Including fluid drag force (Stokes drag force) and acoustic radiation force (acoustic radiation force) generated by vortex. figure 2 It is a schematic diagram and an experimental result diagram of the UHF bulk acoustic wave resonator in the method and equipment provided by the present invention to generate bulk acoustic waves and acoustic current vortices in the cavity, and the effect on particles in the solution.
[0084] figure 2 (A) is a schematic diagram of the UHF bulk acoustic wave resonator in the method and device provided by the present invention generating bulk acoustic waves and acoustic current vortices in the cavity, and the effect on particles in the solution. ...
Embodiment 3
[0088] In the field of biotechnology and clinical medicine, biological samples that need to extract biological macromolecules such as nucleic acid or protein may be samples with complex content and high viscosity, such as whole blood samples and sputum samples. In other forms of liquid actuation and agitation of solution samples using acoustics, high power is often required, thus resulting in high temperatures in the solution (especially small volume solutions), causing damage to desired cells or nucleic acids, etc., or requiring the addition of Additional reagents, but thus have an impact on subsequent reactions.
[0089] The inventors used the device and method of the present invention for generating bulk acoustic waves and swirling flow in a solution in a cavity by using a UHF bulk acoustic wave resonator to conduct experiments in a liquid with high viscosity. Add 0.5 μl of fluorescently labeled PS particles with a particle size of 30 um (Shanghai Huizhi Biotechnology Co., ...
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