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Anthraquinone compound and preparation method of anthraquinone compound from ranunculus davidii

A compound, the technology of anthraquinones, applied in the field of preparation of anthraquinones, can solve the problem of not separating out anthraquinones

Active Publication Date: 2021-03-05
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Studies have shown that many natural products such as tannins, saponins, flavonoids, polyphenols, alkaloids, anthocyanins, cardiac glycosides, phytosterols, coumarins, and diterpenes can be isolated from buttercups. Records on the isolation of anthraquinone compounds

Method used

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preparation example Construction

[0036] In a second aspect, the present invention provides a method for preparing the anthraquinone compound from Buttercup thorn, comprising the following steps:

[0037] The total extract is obtained after pulverizing, extracting, and concentrating the extract;

[0038] The total extract was separated by silica gel column chromatography, and chloroform-methanol system gradient elution was used to obtain 8 components in sequence;

[0039] The fifth component is eluted with a gradient of chloroform-methanol to obtain the compound of formula (I) and compound of formula (II).

[0040] In some embodiments, the gradient elution procedure for the fifth component using the chloroform-methanol system is: 100:5-20, v / v.

[0041] In some embodiments, the compound β-glucopyranoside is also obtained after the fifth component is eluted with a chloroform-methanol system gradient.

[0042] In some embodiments, the crushed Buttercup thorn has a particle size of 20-40 mesh.

[0043] In some...

Embodiment

[0049] experiment apparatus

[0050] Nicolet-510P infrared spectrometer (USA), v max in cm -1 The unit is Bruker AMX-400 nuclear magnetic resonance instrument, TMS is the internal standard, the chemical shift is expressed in δ, and the coupling constant is expressed in J.

[0051] Extraction and Separation Methods

[0052]3.4kg of ranunculus thorns were crushed, leached with 10L ethanol at room temperature, the filtrate was filtered, and concentrated under reduced pressure to obtain 6.5g of the total extract. The total extract was separated by silica gel column chromatography, and the chloroform-methanol system was used for gradient elution (100:5~100:20, v / v). This time, (100:5, v / v), (100: 10, v / v), (100:15, v / v) and (100:20, v / v) were eluted to obtain 8 fractions (F1-8), and fraction F5 (155 mg) was treated with chloroform-methanol Gradient elution of the system (100:10, v / v) and (100:15, v / v) gave compound muracatane A (10.4 mg), compound muracatane B (5.6 mg) and comp...

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Abstract

The invention discloses an anthraquinone compound and a preparation method of the anthraquinone compound from ranunculus davidii. The structural formula of the anthraquinone compound is (muracatans B). The inventor extracts the two anthraquinone components from ranunculus davidii for the first time, and separates the known compound beta- glucopyranoside from ranunculus davidii, tests find that muracatanes B has an alpha-glucosidase inhibition effect, IC50 is 164.46 + / -83.04 microns and has a stronger inhibition effect than standard acarbose. Great application prospects are realized in the preparation of the medicine for treating diabetes mellitus.

Description

technical field [0001] The invention belongs to the technical field of preparation of anthraquinone compounds, and in particular relates to an anthraquinone compound and a preparation method thereof from buttercup thorns. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Buttercup thorn is an annual herb of the family Ranunculaceae, which grows in wet fields and beside rivers. The plant is widely distributed in Asia, Australia, South America and Europe. Buttercup thorn is mainly used to treat tonsillitis among folks in Haryana, northwest India. In my country, Ranunculus has a long history of being used as medicine, such as ranunculus, ranunculus, and ranunculus. According ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/95C07C67/56C07C50/34C07C46/10
CPCC07C69/95C07C67/56C07C50/34C07C46/10C07C2603/24
Inventor 张进杰希达悦·侯赛因张宇伊夫蒂哈尔·阿里吕翠张浩崔莉王岱杰娜嘉·恩格尔
Owner NINGBO UNIV
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