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Application of callicarpae nudiflorae folium in preparation of medicine used for regulating vaginal flora disturbance, and medicine used for regulating vaginal flora disturbance

A technology of nude flower purple pearls and drugs, which is applied in the field of medicine, can solve problems such as high recurrence rate, damage to the mucosal barrier, vaginal microecological imbalance, etc., and achieve the goal of adjusting vaginal flora disorder, increasing species, and increasing biodiversity index Effect

Pending Publication Date: 2021-03-19
HAINAN JIUZHITANG PHARMACY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, local or systemic antifungal drugs are mainly used clinically for treatment, but these drugs often cause vaginal microecological imbalance, damage the mucosal barrier, and the recurrence rate is extremely high after stopping the drug

Method used

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  • Application of callicarpae nudiflorae folium in preparation of medicine used for regulating vaginal flora disturbance, and medicine used for regulating vaginal flora disturbance
  • Application of callicarpae nudiflorae folium in preparation of medicine used for regulating vaginal flora disturbance, and medicine used for regulating vaginal flora disturbance
  • Application of callicarpae nudiflorae folium in preparation of medicine used for regulating vaginal flora disturbance, and medicine used for regulating vaginal flora disturbance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 naked flower purple bead suppository and preparation method thereof

[0028] (1) Take raw materials by the following parts by weight:

[0029] Nude Flower Purple Pearl Dried Herbs 2000g

[0030] Polyethylene glycol 6000 406g Polyethylene glycol 1500 708g

[0031] (2) Add water and heat and extract 3 times for the medicinal material of purple pearl of nudibranchs, the first and second times are 2 hours each, and the third time is 1 hour, the decoction is combined, filtered, the filtrate is concentrated into an extract, and dried into a dry paste powder;

[0032] (3) Heat and melt polyethylene glycol 6000 and polyethylene glycol 1500, keep warm at 60-64°C, make matrix, and set aside;

[0033] (4) Take the dry paste powder of Auranthus nudica extract, pre-dissolve it with 216g of water (90°C), grind it into a colloidal mill to make an extract, keep it warm at 50-55°C, and make a thick paste of Aurantia syringa, which will be used for later use. The weight o...

Embodiment 2

[0036] Example 2 Nudehua Zizhu suppository, the application of the combination of nudehuazizhu suppository and clotrimazole suppository to adjust vaginal flora

[0037] In this experiment, Candida albicans was used to induce the disordered vaginal flora in mice, and 16S rRNA and 18S rRNA microbial sequencing was used as a technical means to observe the regulatory effect of Nudehua Zizhu Suppository on vaginal flora disorder.

[0038] 1 material

[0039] 1.1 Reagent

[0040] Naked flower Zizhu suppository (Hainan Jiuzhitang Pharmaceutical Co., Ltd., batch number 180051); clotrimazole suppository (Harbin Outai Pharmaceutical Co., Ltd., batch number 20180102); polyethylene glycol 1500 (Hunan Erkang Pharmaceutical Co., Ltd., batch number 103120171102 ); polyethylene glycol 6000 (Hunan Erkang Pharmaceutical Co., Ltd., batch number 103120171102). Estradiol Benzoate Injection (Ningbo Sansheng Pharmaceutical Co., Ltd., batch number 20180101); 0.9% Sodium Chloride Injection (Hunan Ka...

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PUM

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Abstract

The invention discloses application of callicarpae nudiflorae folium in preparation of a medicine used for regulating vaginal flora disturbance. In addition, the invention provides the medicine used for regulating the vaginal flora disturbance. The main raw material medicine of the medicine disclosed by the invention is callicarpae nudiflorae folium, and the medicine also can be a combined medicine of which the main raw material medicines are the callicarpae nudiflorae folium and clotrimazole.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of the nude flower purple pearl in regulating the disorder of vaginal flora and the medicine thereof. Background technique [0002] The imbalance of vaginal flora is caused by the imbalance of vaginal microorganisms. The diseases and complications caused by it are mainly pelvic inflammatory disease, vaginal disease, etc. in gynecological diseases, and abortion and premature birth in obstetrical diseases. Candida is a normal vaginal resident flora and is a common conditional pathogen of female reproductive tract infection. The infection rate showed a clear upward trend. Vulvovaginal candidiasis (VVC), also known as candidal vaginitis, is the most common vulvovaginal inflammation in gynecology. Millions of women are infected with VVC every year, seriously affecting female patients Quality of Life. [0003] At present, local or systemic antifungal drugs are main...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K9/02A61P15/02A61P31/10A61K31/4174
CPCA61K36/85A61K31/4174A61K9/02A61K47/10A61P15/02A61P31/10A61K2300/00
Inventor 颜冬兰黄胜李伟袁莉徐向平叶惠煊胡丽彬吴崇乐
Owner HAINAN JIUZHITANG PHARMACY
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