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A kind of chitosan/mxene antibacterial composite sponge for hemostasis and preparation method thereof

A technology of composite sponge and chitosan, applied in application, pharmaceutical formulation, surgical adhesive and other directions, can solve the problems of poor flexibility of hemostatic sponge, increased process complexity, insignificant hemostatic effect, etc., and is conducive to large-scale industrial production. , Improve flexibility, expand the effect of application

Active Publication Date: 2022-03-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although chitosan has dual properties of hemostasis and antibacterial properties, a single non-alkaline chitosan hemostatic sponge has poor flexibility and is easy to collapse when exposed to water (Carbohyd. Polym., 2017, 174, 432-442), and the hemostatic effect is not significant. Weak healing ability, difficult to meet the requirements of war wound hemostasis and clinical rapid hemostasis
The alkalization treatment not only increases the complexity of the process, but also the residual alkali will stimulate the deterioration of the wound
In addition, the alkalization process may destroy the original structure of the sponge, which is not conducive to blood enrichment (RSC Adv., 2017, 7, 34655-34663)

Method used

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  • A kind of chitosan/mxene antibacterial composite sponge for hemostasis and preparation method thereof
  • A kind of chitosan/mxene antibacterial composite sponge for hemostasis and preparation method thereof
  • A kind of chitosan/mxene antibacterial composite sponge for hemostasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of hemostasis chitosan / MXENE antibacterial composite sponge, the specific steps are as follows:

[0033] (1) Under stirring conditions, chitosan having a molecular weight of 100,000 was added to a acetic acid solution having a volume percent concentration of 0.4% to obtain a chitosanic acid solution having a chitosan concentration of 5 g / L.

[0034] (2) Under stirring, N- (2-hydroxyethyl) acrylamide (N- (2-hydroxyethyl) acrylamide (N- (2-hydroxyethyl) acrylamide is added to the chitosan acetate solution to the chitosanic acid solution. Uniform, given a mixed solution;

[0035] (3) Under stirring conditions, add Ti to a mixed solution. 3 C 2 T x , Mix evenly, get 0.5 g / l ti 3 C 2 T x Chitosan / N- (2-hydroxyethyl) acrylamide / Ti 3 C 2 T x The mixed solution; the mixed solution was freeze dried to give the hemostasis chitosan / MXENE antibacterial composite sponge.

[0036] Example 1 The chitosan / MXENE antibacterial composite sponge showed a complex longi...

Embodiment 2

[0040] Preparation of hemostasis chitosan / MXENE antibacterial composite sponge, the specific steps are as follows:

[0041] (1) Under stirring conditions, the molecular weight is added to a acetic acid solution having a molecular weight concentration of 0.5% by 0.5% by weight, to obtain a chitosanic acetate acid solution having a chitosan concentration of 5 g / L;

[0042] (2) Under stirring conditions, N- (2-hydroxyethyl) acrylamide (1: 2 of the chitosan) was mixed in the chitosanic acetate solution to obtain a mixed solution;

[0043] (3) Under stirring conditions, add Ti to a mixed solution. 3 C 2 T x , Mix evenly, get 5g / lti 3 C 2 T x Chitosan / N- (2-hydroxyethyl) acrylamide / Ti 3 C 2 T x The mixed solution; the mixed solution was freeze dried to give the hemostasis chitosan / MXENE antibacterial composite sponge.

[0044] Example 2 Micro-morphological data for chitosan / MXENE antibacterial composite sponge figure 1 Indicated by figure 1 It can be seen that the composite...

Embodiment 3

[0048] Preparation of hemostasis chitosan / MXENE antibacterial composite sponge, the specific steps are as follows:

[0049] (1) Under stirring, a molecular weight of 25,000 shell glycans was dissolved in a vivo acetic acid solution having a percentage concentration of 0.8% to obtain a chitosan solution having a chitosan concentration of 5 g / L.

[0050] (2) Under stirring, N- (2-hydroxyethyl) acrylamide (N- (2-hydroxyethyl) acrylamide (N- (2-hydroxyethyl) acrylamide is 1: 1), and mixed in chitosan acetate solution. Uniform, given a mixed solution;

[0051] (3) Under stirring conditions, add Ti to a mixed solution. 3 C 2 T x , Mix evenly, get 20g / lti 3 C 2 T x Chitosan / N- (2-hydroxyethyl) acrylamide / Ti 3 C 2 T x The mixed solution; the mixed solution was freeze dried to give the hemostasis chitosan / MXENE antibacterial composite sponge.

[0052] Example 3 Preparation of chitosan / MXENE antibacterial composite sponge showed a microstructure of complex longitudinal interle...

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Abstract

The invention discloses a chitosan / Mxene antibacterial composite sponge for hemostasis and a preparation method thereof. The method comprises: taking chitosan as a raw material, N-(2-hydroxyethyl) acrylamide as a monomer, Ti 3 C 2 T x As an enhancer, a chitosan / Mxene composite hemostatic sponge for hemostasis was prepared by vacuum freeze-drying. The chitosan / Mxene composite sponge obtained by the present invention solves the problem that the chitosan sponge collapses when it encounters water, has excellent flexibility, porosity, and the ability to quickly absorb water and expand in a short time, and can quickly absorb blood and cause damage to surrounding tissues. Physical compression can promote wound hemostasis and healing, and can be used for rapid hemostasis and wound healing of various wounds and cavities, and has a good clinical application prospect.

Description

Technical field [0001] The present invention relates to the field of biomedical materials, and more particularly to a hemostasis chitosan / MXENE antibacterial composite sponge and a preparation method thereof. Background technique [0002] In recent years, uncontrolled bleeding is still the main reason for patient death. In emergency treatment, hemostasis is heavy, and the patient's survival is largely associated with bleeding, in order to better Controlling the bleeding of trauma, the researchers are constantly looking for, developing efficient, safe hemostasis materials. Currently, there are many of the market that can be used in clinical hemostasis materials such as zeolite powder, Arista hemostasis microspheres, medical gelatin sponges. Although they all have hemostasis, there are still many shortcomings. [0003] Chitosan is a natural polycore polysaccharide, which is deacety with acetyl moiety. It has good biocompatibility, biodegradability, internal hemostasis and antibac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00A61L24/02
CPCA61L24/0078A61L24/0015A61L24/0036A61L2400/04A61L2300/102A61L2300/236A61L2300/404A61L2300/418C08L5/08Y02A50/30
Inventor 王小英吴正国唐淑玮
Owner SOUTH CHINA UNIV OF TECH