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Preparation method of chitosan/poloxamer composite membrane

A technology of poloxamer and chitosan, which is applied in the field of chitosan/poloxamer composite membrane preparation to achieve outstanding mechanical properties and outstanding antibacterial properties.

Inactive Publication Date: 2021-03-19
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this study, chitosan and poloxamer were used as raw materials, acetic acid was used as solvent, glycerol was used as solubilizer, and the method of pouring evaporation to prepare chitosan / poloxamer composite film has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0015] Dissolve chitosan in acetic acid to obtain a uniform chitosan solution, and stir evenly for 60 minutes; then add sodium bicarbonate solution after fully dissolving, and put the obtained uniform mixture into a vacuum The oven was used for degassing. After the air bubbles disappeared, the transparent solution was poured into the formwork, dried in the oven for 6 hours, the formwork was taken out, and the film was finally peeled off on the formwork to obtain a chitosan film.

example 2

[0017] Dissolve chitosan in acetic acid to obtain a uniform chitosan solution, and stir evenly for 60 minutes; then add glycerol and stir evenly for 30 minutes; finally stir The final homogeneous solution was put into a vacuum oven for degassing for 60 minutes. After the bubbles disappeared, the transparent solution was poured into the template, dried in an oven for 4 hours, the template was taken out, and the film was peeled off on the template to obtain a glycerol / chitosan composite film.

example 3

[0019] Stir the poloxamer in deionized water until the poloxamer is completely dissolved in the water, and the solution is in a clear and transparent state. The stirring time is preferably 30 minutes; dissolve the glycerol in the deionized water; the stirring time is 5 minutes. Appropriate; add the chitosan solution under the condition of stirring, mix the three solutions and perform ultrasonic treatment, the treatment time is preferably 10 minutes; place the obtained uniform mixture in a water bath with a temperature of 60°C for reaction 30 minutes. After the reaction, pour the transparent solution into the template, dry it in the oven for 6 hours, take out the template, peel off the film on the template, and put the film in sodium hydroxide solution for alkali treatment to remove excess acetic acid when the temperature of the film returns to room temperature , The time is preferably 2 hours. After taking it out, rinse the film with deionized water to achieve the purpose of w...

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Abstract

The invention relates to a preparation method of a chitosan / poloxamer composite membrane. The chitosan / poloxamer composite membrane is prepared from the following raw materials: chitosan, poloxamer, asolubilizing agent, an alkali treatment reagent and deionized water. According to the preparation method, firstly, poloxamer is added into a chitosan solution, so hydroxyl groups on chitosan molecules and carboxyl groups on poloxamer are combined to generate new hydrogen bonds; then glycerol is added to improve toughness, distances between molecular chains are increased due to the addition of glycerol, the mobility of the chitosan molecular chains is improved, and a chitosan / poloxamer membrane casting solution is prepared through the solubilizing effect of the glycerol; and finally, the chitosan / poloxamer composite membrane is obtained through a pouring evaporation method. The chitosan / poloxamer composite membrane with excellent mechanical properties and antibacterial properties is prepared by controlling a material ratio of chitosan to poloxamer, the addition amount of the solubilizer, time, temperature and other factors.

Description

[0001] technical field [0002] The invention relates to a preparation method of a chitosan / poloxamer composite film. [0003] technical background [0004] Chitosan is a deacetylated derivative of chitin, which widely exists in the cell walls of algae, fungi, and shells of insects, shrimps, etc. inferior to cellulose. Chitosan is a cationic polysaccharide. Chitosan and its derivatives have good antibacterial properties, good degradability, and low toxicity. [0005] Poloxamer is a white spherical particle, odorless, tasteless, soluble in water, acid, and alkali, with a unique polyoxypropylene hydrophobic core and polyoxyethylene hydrophilic shell structure, stable to metal ions; it is a surfactant, It can increase the solubility of some insoluble drugs; it has a special reverse thermal gelation effect, that is, it is liquid at low temperature (4°C-5°C), and becomes a gel at body temperature. It is convenient for application and prolongs the drug at the administration site. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L5/08C08L71/02C08K5/053
CPCC08J5/18C08J2305/08C08J2371/02C08J2405/08C08J2471/02C08K5/053
Inventor 赵梓年刘祯浩李征征
Owner TIANJIN UNIV OF SCI & TECH
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