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Moisturizing and bacteriostatic gel containing aloe arborescens extract and preparation method of moisturizing and bacteriostatic gel

A technology of aloe vera extract and gel, which is applied in the directions of medical preparations containing active ingredients, preparations for skin care, pharmaceutical formulas, etc. It has the effect of improving the poor solubility of fat and no toxic and side effects.

Active Publication Date: 2021-03-26
山东爱维德生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when preparing Aloe arborescens cosmetics, it is often difficult to prepare such complex components into a uniform solution or emulsion. Many aloe cosmetics will precipitate after being placed for a long time. Adding surfactants to cosmetics can make the hydrophilic and Hydrophobic substances are combined to prepare a homogeneous solution, but there are problems of easy foaming and difficult rinsing, which brings a very poor experience to cosmetics, and a large amount of surfactants are added to cause damage to sensitive baby skin
In addition, Aloe arborescens extract is rich in carbohydrates, proteins, fatty acids and other substances, which are easy to breed bacteria and cause cosmetics to deteriorate. Babies are more likely to breed bacteria on the skin surface due to lack of hygiene.
Therefore, it is very important for the development of baby aloe cosmetics industry to develop new technologies to solve the problems of unstable quality, perishable, bacteria breeding and side effects faced by Aloe arborescens cosmetics

Method used

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  • Moisturizing and bacteriostatic gel containing aloe arborescens extract and preparation method of moisturizing and bacteriostatic gel
  • Moisturizing and bacteriostatic gel containing aloe arborescens extract and preparation method of moisturizing and bacteriostatic gel
  • Moisturizing and bacteriostatic gel containing aloe arborescens extract and preparation method of moisturizing and bacteriostatic gel

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preparation example Construction

[0042] The preparation method of described nano-silver modified chitosan is as follows:

[0043] Dissolving chitosan in acetic acid aqueous solution with a mass concentration of 0.5%, adding silver nitrate, stirring at 20-30°C for 1-3 hours, and freeze-drying to obtain chitosan dry powder; adding chitosan dry powder to 0.5mol / Put in an aqueous solution of 1 L of ascorbic acid, place on a shaker, shake at a temperature of 20-30°C for 2-4 hours, filter, wash with an aqueous ethanol solution with a mass percent concentration of 40%-60%, and add the filter cake to 0.1mol / L sodium hydroxide aqueous solution, placed on a shaker again, shaken at 20-30°C for 4-6 hours, filtered, washed with ethanol aqueous solution with a mass percentage concentration of 5%-15%, and freeze-dried to obtain nano-silver Modified chitosan; wherein chitosan, acetic acid aqueous solution, silver nitrate, 0.5mol / L ascorbic acid aqueous solution, ethanol aqueous solution with a mass percentage concentration ...

Embodiment 1

[0061] Preparation of N-oleic acid amido-2-deoxy-D-glucose

[0062] Add 100g of glucosamine hydrochloride to a mixture of 3000g of dichloromethane and methanol (dichloromethane:methanol=1:1), add 160g of oleic acid and 110g of 1-(3-dimethylamino Propyl)-3-ethylcarbodiimide hydrochloride, stirred and reacted at 10°C for 12 hours, the resulting reaction solution was distilled off under reduced pressure to remove the solvent, and the resulting solid was recrystallized with 1200g of methanol to obtain N-oleic acid amide base-2-deoxy-D-glucose.

Embodiment 2

[0064] Preparation of N-linoleic acid amido-2-deoxy-D-glucose

[0065] Add 100g of glucosamine hydrochloride to a mixture of 5000g of dichloromethane and methanol (dichloromethane:methanol=1:1), add 200g of linoleic acid and 150g of 1-(3-dimethyl Aminopropyl)-3-ethylcarbodiimide hydrochloride, stirred and reacted at 40°C for 48 hours, the resulting reaction solution was distilled off under reduced pressure to remove the solvent, and the resulting solid was recrystallized with 1500g of methanol to obtain N-linoleic acid Acid amido-2-deoxy-D-glucose.

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Abstract

The invention discloses a moisturizing and bacteriostatic gel containing an aloe arborescens extract. The moisturizing and bacteriostatic gel is prepared from the following raw materials: water, allantoin, the aloe arborescens extract, glycerol, N-fatty acylamino-2-deoxy-D-glucose, glucan and the like. The N-fatty acylamino-2-deoxy-D-glucose is added into the aloe arborescens gel in the invention;the compound not only contains a hydrophobic aliphatic chain, but also contains a hydrophilic glycosyl; according to the principle of similarity and intermiscibility, the hydrophobic aliphatic chainhas good affinity with a water-insoluble compound in the aloe arborescens extract; the glycosyl has good affinity with a water-soluble compound in the aloe arborescens extract, so that the aloe arborescens extract can form a uniform solution by adding the N-fatty acylamino-2-deoxy-D-glucose; and compared with a surfactant, the N-fatty acylamino-2-deoxy-D-glucose does not foam in the system and iseasy to rinse.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a moisturizing and antibacterial gel containing aloe arborescens extract, and also relates to a preparation method of the gel. Background technique [0002] Aloe arborescens belongs to the genus Aloe, which has the characteristics of perennial, evergreen, and succulent. Aloe arborescens is rich in aloin, emodin, aloin, isoaloepicrin, flavonoids, and anthraquinone compounds, which have anti-inflammatory, anti-oxidation, anti-cancer, lowering blood pressure, treating constipation, softening blood vessels, and promoting urination , inhibit bacterial regeneration, promote red blood cell growth and other pharmacological activities. In traditional Chinese medicine, Aloe arborescens is often used as a traditional Chinese medicine for clearing liver heat, detoxifying, and moistening intestines. In addition, Aloe arborescens also contains a large amount of macromolecular compounds suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/60A61K8/73A61K8/19A61K8/04A61Q19/00A61Q17/00A61Q19/08
CPCA61K8/9794A61K8/60A61K8/736A61K8/19A61K8/73A61K8/735A61K8/042A61Q19/005A61Q17/005A61Q19/08A61K2800/84A61K2800/592A61K2800/56
Inventor 徐传国潘殿玲张玙璠张海峰
Owner 山东爱维德生物科技有限公司
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