Traditional Chinese medicine composition for treating Alzheimer's disease and preparation process thereof

A technology for Alzheimer's disease and a composition, which is applied in the field of medicine to achieve the effects of improving the extraction rate, improving the extraction efficiency of saponins, and increasing the content

Inactive Publication Date: 2021-03-30
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing main hypothesis is that the excessive accumulation of amyloid β plaques in the pathogenesis of AD, and the hyperphosphorylation of Tau protein to produce neurofibrillary tangles mediate the final pathogenesis process. Explain many problems in the pathogenesis of AD

Method used

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  • Traditional Chinese medicine composition for treating Alzheimer's disease and preparation process thereof
  • Traditional Chinese medicine composition for treating Alzheimer's disease and preparation process thereof
  • Traditional Chinese medicine composition for treating Alzheimer's disease and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Liquid preparation and administration:

[0039] The configuration of the medicinal solution for oral administration of the prescription: mix according to the prescription ratio in Table 1, add 10 times the amount of water, decoct for 2 hours, collect the filtrate, add the same amount of water to the residue and continue decocting for 1 hour, filter and combine the filtrate, and concentrate to 1g / mL (Based on crude drug amount) liquid medicine, refrigerated for future use.

[0040] 84 mice were randomly divided into 7 groups, the control group of the blank group: intragastric administration of double distilled water, once a day, for 8 consecutive weeks; the D-gal model group: subcutaneous injection of D-gal (125mg / kg / d) in the neck, Double distilled water was administered by intragastric administration for 8 consecutive weeks; Piracetam group: 208 mg / kg / d of piracetam was administered by intragastric administration, and D-gal (125 mg / kg / d) was injected subcutaneously ...

Embodiment 2

[0070] A preparation method of a traditional Chinese medicine composition for treating Alzheimer's disease: comprising the following steps:

[0071] S01 Take 6 parts by weight of dried Cistanche, pulverize and sieve to obtain Cistanche coarse powder; take 9 parts by weight of dried Cistanche vine, grind and sieve to obtain Cistanche coarse powder; put Cistanche coarse powder put into the cloth bag, and put the cistanche coarse powder and the cloth bag containing the gallinaceous rattan coarse powder in the container, with 30% ethanol solution as the solvent, add 40% of the total weight of the cistanche coarse powder and the gallinaceous rattan coarse powder for the first time. Doubling the solvent, heating and refluxing for extraction for 1.5 hours, take out the cloth bag containing the mealy powder of Coccinosa, filter the filtrate to obtain the first extract; add 20 times the weight of the mealy powder of Cistanche cistanche for the second time in 30% ethanol solution, After...

Embodiment 3

[0078] A preparation method of a traditional Chinese medicine composition for treating Alzheimer's disease: comprising the following steps:

[0079] S01 Take 6 parts by weight of dried Cistanche, pulverize and sieve to obtain Cistanche coarse powder; take 9 parts by weight of dried Cistanche vine, grind and sieve to obtain Cistanche coarse powder; put Cistanche coarse powder put into the cloth bag, and put the cistanche coarse powder and the cloth bag containing the gallinaceous rattan coarse powder in the container, first time use 50% ethanol solution as the solvent, add 20% of the total weight of the cistanche coarse powder and the gallinaceous rattan coarse powder Doubling the solvent, heating and refluxing for extraction for 1.5 hours, take out the cloth bag containing the coarse powder of Coccinosa, filter the filtrate, and obtain the extract for the first time; add 50% ethanol solution equivalent to 10 times the weight of the coarse powder of Cistanche cistanche for the s...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating Alzheimer's disease. The traditional Chinese medicine composition is prepared from the following raw materials in partsby weight: 10-20 parts of potentilla anserine, 6-18 parts of herba cistanche, 9-21 parts of panax japonicus, 9-21 parts of psammosilene tunicoides, 9-15 parts of Chinese fevervine herb, 6-9 parts of clinopodium chinense and 3-9 parts of herba violae. The traditional Chinese medicine composition can be used for preventing and treating Alzheimer's disease, is a pure traditional Chinese medicine preparation, and is safe, low in toxicity, cheap and easy to prepare. According to the invention, pharmacological and pharmacodynamic experiments prove that compared with western medicines commonly used in the prior art, the treatment effect of the traditional Chinese medicine composition is obviously improved. The invention further provides a preparation process of the traditional Chinese medicine composition for treating the Alzheimer's disease. The preparation method is simple in process, beneficial to large-scale industrial production operation and small in pollution.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition for treating Alzheimer's disease and a preparation process thereof. Background technique [0002] Alzheimer's disease (AD) patients may experience symptoms such as memory loss, behavioral impairment, aphasia, apraxia, and decreased ability to live. The long-term course of the disease brings a heavy burden on the patients themselves, their families and society. According to epidemiological research statistics, it is estimated that there will be 130-150 million Alzheimer's patients in the world in 2050. All clinical trials of new drug research aimed at abnormal deposition of Aβ have failed. Therefore, up to now, there is no drug that can completely cure the disease, and the few drugs that can improve the clinical symptoms of AD have many adverse reactions. Although the clinical drugs represented by donepezil are effective, they only ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61P25/28
CPCA61K36/258A61K36/36A61K36/53A61K36/64A61K36/73A61K36/74A61K36/86A61K2236/19A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P25/28A61K2300/00
Inventor 刘斌孙琪郑智洋赵雨欣周新茹赵超凡郝奥林赵晨宇张怡博姚睿敏郭婷秀徐艳明张宁王发善
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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