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A kind of antibacterial application of dehydromethrin c

A technology for dehydromethrin and its use, which is applied in the field of medicine, can solve problems such as unseen literature or patent reports, and achieve the effects of simple separation and purification, improved survival rate, high yield and purity

Active Publication Date: 2022-03-01
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no literature or patent report on the research on dehydrosmelachin C as an antibacterial drug

Method used

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  • A kind of antibacterial application of dehydromethrin c
  • A kind of antibacterial application of dehydromethrin c
  • A kind of antibacterial application of dehydromethrin c

Examples

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Embodiment Construction

[0055] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The examples are only used to explain the present invention, not to limit the protection scope of the present invention.

[0056] (1) Preparation of isoguaialide C ( figure 1 )

[0057] a) In a 250mL double-necked flask, add dehydrocoylolide (3.0g, 13.0mmol), SeO 2 (0.723g, 6.5mmol) and tert-butanol peroxide (3.6mL, 26.0mmol), and then 150mL of dichloromethane was added to obtain a reaction mixture. The reaction mixture was stirred at room temperature for 2h, and the reaction was monitored by TLC.

[0058] b) After the reaction finishes, the reaction product is washed with 10mL saturated Na 2 SO 3 The solution was washed twice to remove excess tert-butanol peroxide, and the organic phase was washed once with 10mL saturated sodium bicarbonate solution and saturated brine respectively, and then washed with anhydrous Na 2 SO 4 After drying, d...

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Abstract

The invention discloses an antibacterial application of dehydromethrin C. Experiments show that dehydromethrin C has significant inhibitory effect on methicillin-resistant Staphylococcus aureus. According to the experimental results, dehydromethrin C has medicinal value in the treatment of Gram-positive bacterial infections, and can be used as an active ingredient in the preparation of antibacterial drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the antibacterial application of dehydromeschrin C. Background technique [0002] In recent years, with the widespread use of antibiotics, the continuous increase and widespread spread of drug-resistant pathogenic bacteria has become a global public health problem. Diseases caused by infections caused by drug-resistant pathogens, such as pneumonia, tuberculosis and salmonellosis, have become more difficult to treat because of the dramatic decline in the effectiveness of antibiotics. In the process of competing with antibiotics, some bacteria have evolved into multidrug-resistant pathogens that can resist multiple antibiotics, and the most difficult to control is methicillin-resistant Staphylococcus aureus (MRSA). MRSA is the main pathogen of hospital-acquired and community-acquired infections. It belongs to Gram-positive bacteria. It is an important cause of bacteremia and septic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61P31/04A61P31/06C07D307/93
CPCA61K31/365A61P31/04A61P31/06C07D307/93C07B2200/07Y02A50/30
Inventor 秦向阳胡兴斌徐金梅
Owner FOURTH MILITARY MEDICAL UNIVERSITY