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preparation example Construction
[0034] The invention provides a preparation method of a pharmaceutical composition, comprising the following steps:
[0035] S101: Clean and pulverize the branches and leaves of laurel, fennel, red myrrh, and black pine, and then use supercritical carbon dioxide to perform the first extraction; wherein, the temperature of the first extraction is 48°C, the pressure is 15.80MPa, and the time is 80min. The flow rate of critical carbon dioxide is 30kg / h.
[0036] S102: Grind the basil, rose geranium and frankincense and mix them evenly, then use the steam distillation method to perform the second extraction, then filter the second extracted product and collect the second filtrate; wherein, the steam distillation time is 300min, The mass ratio of the added mass of water to the pulverized product is 5:1.
[0037] S103: Extract grape seeds and argans by cold pressing method; wherein, in a preferred embodiment, the pH of the cold pressing method is 7-8, and the temperature is 5-10°C....
Embodiment 1
[0049] The pharmaceutical composition of this embodiment includes: 50 parts by weight of oleic acid, 35 parts by weight of linoleic acid, 7 parts by weight of palmitic acid, 3 parts by weight of stearic acid, 2 parts by weight of α-pinene, 1 part by weight of limonene, eucalyptus 1 part by weight of oleyl alcohol, 1 part by weight of anethole, 1 part by weight of 3-thujene, 1 part by weight of β-pinene, 1 part by weight of trans-caryophyllene, 1 part by weight of α-santalene, 1 part by weight of sabinene Parts by weight, 1 part by weight of ocimene, and 1 part by weight of p-cymene: the above raw material components are mixed uniformly to obtain a pharmaceutical composition, which is placed in a brown bottle for use.
Embodiment 2
[0051] The pharmaceutical composition of this embodiment includes: 48 parts by weight of oleic acid, 37 parts by weight of linoleic acid, 7 parts by weight of palmitic acid, 3 parts by weight of stearic acid, 2 parts by weight of α-pinene, 2 parts by weight of limonene, eucalyptus 2 parts by weight of oleyl alcohol, 1 part by weight of anethole, 1 part by weight of 3-thujene, 1 part by weight of β-pinene, 1 part by weight of sabinene, 1 part by weight of ocimene, and 1 part by weight of p-cymene: The above raw material components are uniformly mixed to obtain a pharmaceutical composition, which is placed in a brown bottle for use.
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PUM
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Abstract
The invention provides an external pharmaceutical composition for improving hyperplasia of mammary glands, and particularly provides a pharmaceutical composition. The pharmaceutical composition comprises the following components in parts by weight: 40-55 parts of oleic acid, 30-40 parts of linoleic acid, 4-8 parts of palmitic acid, 1-5 parts of stearic acid, 0.5-5 parts of alpha-pinene, 0.5-4 parts of limonene, 0.5-3 parts of eudesmol, 0.2-3 parts of anethole, 1-3 parts of 3-thujene and 1-2 parts of beta-pinene. The pharmaceutical composition can be used for patients with hyperplasia of mammary glands in the form of transdermal administration, thereby improving or controlling symptoms of the patients.
Description
technical field [0001] The invention relates to the field of medicine, in particular, the invention provides an external pharmaceutical composition for improving mammary glandhyperplasia. Background technique [0002] Mammary gland hyperplasia refers to hyperplasia of mammary glandepithelium and fibrous tissue, structural degeneration of breast tissue ducts and lobules, and progressive connective tissue growth. The main cause of the disease is endocrine hormone imbalance. Mammary gland hyperplasia is the most common breast disease in women, and its incidence rate accounts for the first place in breast diseases. In recent years, the incidence of the disease has been increasing year by year, and the age is getting younger and younger. According to the survey, about 70% to 80% of women have hyperplasia of mammary glands in various degrees, and it is more common in women aged 25 to 45. The clinical manifestations have different characteristics in different age groups. Unmarr...
Claims
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