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Method for researching relationship between HSD17B13 rs72613567 gene variation and renal function injury

A gene mutation and kidney function technology, applied in the medical field, can solve problems affecting adult kidney function, unclear, etc.

Pending Publication Date: 2021-04-09
WUXI NO 2 PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether the function of the rs72613567 variant affects renal function / injury in adults is unknown

Method used

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  • Method for researching relationship between HSD17B13 rs72613567 gene variation and renal function injury
  • Method for researching relationship between HSD17B13 rs72613567 gene variation and renal function injury
  • Method for researching relationship between HSD17B13 rs72613567 gene variation and renal function injury

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Experimental program
Comparison scheme
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Embodiment 1

[0019] (1) Crowd screening

[0020] In a cross-sectional study, we included 215 adult NAFLD patients who were consecutively admitted to the First Affiliated Hospital of Wenzhou Medical University from December 2016 to February 2019. All participants had confirmed NAFLD by liver biopsy. The study was approved by the local ethics committee. Written informed consent was obtained from participants and personal information and records were deleted prior to analysis.

[0021] (2) Liver histological biopsy

[0022] All liver biopsy specimens were analyzed by experienced liver pathologists who were blinded to the clinical data of the participants. Histological features of NAFLD were defined according to NASH CRN classification and Brunt's criteria.

[0023] (3) Genetic analysis

[0024] Blood samples from all patients were first collected, and approximately 20 ng of genomic DNA was extracted from each blood sample for genetic analysis. DNA was extracted using a QIAGEN kit and st...

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Abstract

The invention discloses a method for researching the relationship between HSD17B13 rs72613567 gene variation and renal function injury, and belongs to the technical field of medicine. According to the invention, a patient verified as NAFLD by biopsy is selected as an experimental population, the HSD17B13 genotype of the patient is detected, the glomerular filtration rate (eGFR), urine / serum NGAL and the ratio (u-ACR) of urine albumin to creatinine of the patient are measured, and finally, the relationship between the HSD17B13 rs72613567 genotype and gene variation and renal function damage is determined by multivariate regression analysis. Results show that the HSD17B13 rs72613567 A / - or A / A genotype is significantly related to a relatively low proteinuria risk, but is irrelevant to u-NGAL concentration or eGFR level, so that a novel insight is provided for early renal injury.

Description

technical field [0001] The invention relates to a method for studying the relationship between HSD17B13 rs72613567 gene variation and renal function damage, and belongs to the field of medical technology. Background technique [0002] Nonalcoholic fatty liver disease (NAFLD) is a syndrome consisting of a series of liver diseases associated with hepatic steatosis, nonalcoholic steatohepatitis, advanced fibrosis, and cirrhosis. The common risk factors of NAFLD and chronic kidney disease (CKD) include: insulin resistance, dyslipidemia, chronic inflammation and enhanced oxidative stress. NAFLD, whether confirmed by imaging or by liver biopsy, was associated with increased prevalence of microalbuminuria, macroalbuminuria, and CKD. There is increasing evidence that several predisposing genetic variants, such as patatin-like phospholipase domain-containing protein-3 (PNPLA3 ) and trans-membrane 6 superfamily member 2 gene (TM6SF2). Our previous study found that NAFLD patients ca...

Claims

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Application Information

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IPC IPC(8): G16H50/20G16B20/00C12Q1/6883
CPCG16H50/20G16B20/00C12Q1/6883C12Q2600/156
Inventor 孙旦芹王瑞芳阎丰
Owner WUXI NO 2 PEOPLES HOSPITAL
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