Hardware-in-the-loop simulation system for antiepileptic electrical stimulation

A simulation system, electrical stimulation technology, applied in the field of biomedical engineering, can solve rare and other problems

Active Publication Date: 2021-04-20
TIANJIN UNIV
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Hardware-in-the-loop simulation platforms currently used in

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  • Hardware-in-the-loop simulation system for antiepileptic electrical stimulation
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  • Hardware-in-the-loop simulation system for antiepileptic electrical stimulation

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[0033] A hardware-in-the-loop simulation system for anti-epileptic electrical stimulation of the present invention will be further described in detail below with reference to the accompanying drawings.

[0034] The design concept of the anti-epileptic electrical stimulation hardware-in-the-loop simulation system of the present invention is firstly driven by the EEG signal (1) data of epileptic patients, based on the data-driven identification to establish a personalized neural cluster model, and using the fourth-order Runge-Kutta in DSP The algorithm solves the differential equation of the model, simulates the epileptiform discharge signal, completes the embedded implementation of the model (10), and outputs the recurring epileptiform discharge signal (17); then the signal conversion module (19) converts the epileptic EEG real-time generator ( 2) The generated recurring epileptiform discharge signal is decompressed, converted into an analog EEG signal with the same amplitude-fr...

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Abstract

The invention relates to a hardware-in-the-loop simulation system for antiepileptic electrical stimulation. The simulation system comprises an epileptic electroencephalogram real-time generator, a signal acquisition module, an electrical stimulation controller and an upper computer. The epileptic electroencephalogram real-time generator converts an input epileptic electroencephalogram signal into an epileptic sample discharge signal through a data driving identification strategy and embedded implementation of a model, then signal acquisition and processing are performed, epileptiform discharge of a personalized neural cluster model is suppressed through a PI closed-loop control strategy based on an unscented Kalman filter, program flows of all the modules are achieved through C language programming, compiled and downloaded into a DSP, communication between an upper computer and the electrical stimulation controller is completed through a LabVIEW platform, the upper computer is mainly used for data communication and waveform display, and the display control effect is achieved. The simulation system has the advantages that real-time simulation verification of an electrical stimulation closed-loop control strategy is achieved, and an important promotion effect is achieved on epilepsy closed-loop control clinics.

Description

technical field [0001] The invention relates to biomedical engineering technology, in particular to an anti-epileptic electrical stimulation hardware-in-the-loop simulation system. Background technique [0002] Epilepsy is one of the most common neurological diseases in the world. Epilepsy is characterized by abnormal brain electrical activity caused by abnormal synchronous discharge of a large group of neurons, which can be captured in the patient's EEG, and epilepsy detection and location can be performed accordingly and diagnosis. Today, there are 50 million epilepsy patients in the world, about 1 / 4 of which cannot be effectively treated by drugs or surgery. These epilepsy are called intractable epilepsy. Antiepileptic drugs are prone to drug resistance, dependence and side effects during treatment. Surgical resection of local lesions is effective in treating localized epilepsy, but the surgical treatment process is irreversible, and may also cause risks such as memory ...

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Application Information

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IPC IPC(8): A61N1/36
Inventor 魏熙乐赵美佳周易非常思远伊国胜王江卢梅丽
Owner TIANJIN UNIV
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