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Method for delivering levosalbutamol to lung in inhaled dry powder

A technology of albuterol and albuterol sulfate, which is applied in the field of medicine and achieves the effect of good hydrodynamic characteristics

Pending Publication Date: 2021-04-23
SUZHOU JUNNING NEW MEDICINE DEV CENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is an unmet clinical need to develop L-salbutamol sulfate into lung inhalation dry powder to achieve the effect of treating pulmonary diseases such as asthma and COPD

Method used

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  • Method for delivering levosalbutamol to lung in inhaled dry powder
  • Method for delivering levosalbutamol to lung in inhaled dry powder
  • Method for delivering levosalbutamol to lung in inhaled dry powder

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0012] Example 1: Hygroscopicity, angle of repose and powder diffraction experiments of three salt forms of levosalbutamine

[0013] Moisture test:

[0014] First, put the washed and dried flat weighing bottle in an artificial climate chamber (setting temperature: 25°C±1°C, relative humidity: 80%±2%) for 24 hours, and accurately weigh m1; The solid raw material medicine of quality standard is used as test product, and test product is placed in above-mentioned weighing bottle and evenly tiled, and test product thickness is generally about 1mm, and accurately weighs m2; Then weigh bottle exposure, and Place the bottle cap under the same constant temperature and humidity conditions for 24 hours, close the cap of the weighing bottle, and accurately weigh m3 after taking it out.

[0015] Calculate the weight gain percentage according to the following formula (1), and the results are shown in Table 1.

[0016]

[0017] Table 1

[0018]

[0019] Angle of repose experiment

...

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Abstract

The invention discloses a preferable method for preparing a dry powder preparation and device by using levosalbutamol sulfate.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the drug application of L-salbutamol sulfate delivered to the lungs in dry powder dosage form for the treatment of pulmonary diseases such as asthma and COPD. Background technique [0002] Salbutamol is mainly used for the treatment of asthma. Generally, commercially available salbutamol is a racemate, which has an R configuration (also known as L- or left-handed isomer) to shift polarized light to the left, and S configuration to rotate polarized light to the right. . The (R)-enantiomer of albuterol is the active isomer, binding to the human β2 receptor, whereas the (S)-enantiomer has little or no activity. Due to the chemical synthesis process, almost all β2 agonists currently used clinically are racemic (etc.) mixtures of (R)- and (S)-isomers. The metabolic rate of (S)-albuterol is 10 times slower than that of (R)-albuterol, and the plasma half-lives are 3 hours and 5 hou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K31/137A61P11/00A61P11/06
CPCA61K9/0073A61K31/137A61P11/06A61P11/00
Inventor 张睿谭律雅徐玲
Owner SUZHOU JUNNING NEW MEDICINE DEV CENT CO LTD
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