A kind of cisplatin ligand and its application in the preparation of tumor nano-diagnosis and treatment agent

A ligand and cisplatin technology, applied in the field of medicine, can solve the problems of cells prone to drug resistance, large toxic and side effects, and poor targeting of drug therapy
CN112704685BActive Publication Date: 2021-09-14NANTONG UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANTONG UNIVERSITY
Publication Date
2021-09-14

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Abstract

The invention discloses a cisplatin ligand and its application in preparing tumor nano-diagnosis and treatment agents, belonging to the technical field of medicine. The fluorescent unit and the singlet oxygen-generating unit are connected to one molecule through metal coordination, and the exterior of the assembly is protected by a glycol chain to make it stable in the body circulation process. At the same time, the metal coordination inhibits the interaction between porphyrins The dense accumulation of the light greatly improves its ability to generate singlet oxygen, thereby improving the anti-tumor efficiency.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a cisplatin ligand and its application in the preparation of nano-diagnosis and treatment agents for tumors. Background technique

[0002] At present, tumor is one of the diseases that pose the greatest threat to human health. Traditional drug therapy is the first choice for tumor treatment, but drug therapy has poor targeting, high toxicity and side effects; poor solubility and stability of drugs; cells are prone to drug resistance ; and the shortcomings of drug delivery and treatment in vivo are difficult to detect. Due to its dynamic reversible characteristics, supramolecular chemistry can well solve the above problems.

[0003] As a typical supramolecular carrier, Pt(II) coordination assembly has also made some progress in supramolecular tumor therapy. Toxicity and side effects (stability of internal circulation), and a supramolecular intelligent tumor treatment...

Claims

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