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Hair growth injection solution based on autologous fat stem cell exosome, and preparation method

An adipose stem cell and exosome technology, applied in the field of biomedicine, can solve the problems of unnatural hair direction and density distribution, large hair grafts, and large damage to the recipient area, achieving no risk of immunogenic reaction, high activity, Achieve the effect of hair regeneration

Inactive Publication Date: 2021-04-27
焕生汇生物基因技术(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned repair methods can repair the loss of hair, but there is still a problem: the hair graft is relatively large, resulting in unnatural hair direction and density distribution after surgery, large damage to the recipient area, low survival rate, and aesthetic impact.

Method used

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  • Hair growth injection solution based on autologous fat stem cell exosome, and preparation method
  • Hair growth injection solution based on autologous fat stem cell exosome, and preparation method

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Effect test

Embodiment 1

[0030] This embodiment of the present invention relates to a hair growth injection based on autologous adipose stem cell exosomes, which is composed of autologous adipose stem cell exosomes and water for injection; wherein, each milliliter of the injection contains 1×10 5 exosomes produced by adipose-derived stem cells.

[0031] The present invention also relates to the preparation method of the aforementioned autologous fat stem cell exosome-based hair growth injection, see figure 1 Shown: described method comprises the steps:

[0032] Step 1, selection of autologous fat;

[0033] Step 2, preparation of fat stem cells;

[0034] Step 3, preparation of adipose-derived stem cell exosomes;

[0035] Step 4, preparation of hair growth injection of adipose stem cell exosomes: add the exosomes obtained above to water for injection to form an injection; make each ml of the injection contain 1×10 5 exosomes produced by adipose-derived stem cells. The obtained injections are tested...

Embodiment 2

[0047] In order to obtain clear evidence of the therapeutic effect of this Shengfa Injection, a one-year pre-treatment experiment was conducted on 5 patients after providing sufficient explanations to the hair loss patients and obtaining their consent. The test method is: use a special hair growth microneedle injector, inject a volume of about 0.02ml into the scalp of each injection site, inject once a week, and inject 4-8 times depending on the extent and degree of hair loss as a course of treatment, and every year Carry out 1-2 courses of treatment. Test results: as follows figure 2 Shown are the effect pictures of 5 patients before and after treatment. After 1-2 courses of treatment for 5 patients, the hair loss was significantly improved, and none of the cases showed rapid hair loss after the treatment was completed. Instead, hair growth increases gradually, usually peaking around 1 year. These results are due to the activation of hair follicle cells by various cytokine...

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Abstract

The invention provides a hair growth injection solution based on an autologous fat stem cell exosome, and a preparation method. The hair growth injection solution consists of the autologous fat stem cell exosome and water used for injection. The preparation method of the hair growth injection solution comprises the following steps of: S1: selecting autologous fat; S2: preparing fat stem cells; S3: preparing the fat stem cell exosome; and S4: preparing the hair growth injection solution of the fat stem cell exosome. The hair growth injection solution based on the autologous fat stem cell exosome can effectively utilize autologous tissues and has the advantages that the hair growth injection solution is easy in operation, does not have an immunogenicity reaction risk, is high in activity, has an obvious effect, has a low preparation cost, is high in operability and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedicine; in particular, it relates to a hair growth injection based on autologous adipose stem cell exosomes and a preparation method thereof. Background technique [0002] Currently, the incidence of hair loss is high, including natural androgenetic hair loss, burn hair loss, traumatic hair loss, iatrogenic hair loss, etc. There are many repair methods for hair loss: scalp expansion, scalp reduction, free scalp strip transplantation, skin flap method, and autologous hair transplantation. [0003] Among them, autologous hair transplantation can be divided into many methods: trephine drilling transplantation, laser drilling transplantation, slit transplantation, etc. The shape of the transplantation includes cylindrical, square, sheet, oval, etc., and each graft contains The number of hairs varies from 4-12. The above-mentioned repair methods can repair hair loss, but there is still a problem: the ha...

Claims

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Application Information

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IPC IPC(8): A61K35/28A61K9/08A61P17/14C12N5/0775
CPCA61K35/28A61K9/0019A61K9/08C12N5/0667A61P17/14C12N2509/10C12N2509/00
Inventor 卓鑫杰高义姚玲玲罗保君杨苗孟德龙宋丹
Owner 焕生汇生物基因技术(北京)有限公司
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