Preparation method of lutein preparation, and lutein preparation
A technology of lutein and preparations, which is applied in the field of medicine, can solve problems such as the loss of active components of lutein and the oxidation of lutein esters, and achieve the effect of reducing oxidation consumption and increasing content
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[0025]Seefigure 1 The present invention provides a method of preparing a lutein formulation comprising the steps of:
[0026]S1: Mix the marigold extract and antioxidant, and melt the first preset time at the first preset temperature to obtain a molten liquid;
[0027]Among them, marigold immersion cream is the product obtained by extracting a solvent such as petroleum ether or the like. The main component is from about 150 mg / g of the content. Marigold extracts are generally present in the form of viscous gels, and the direct processing is difficult. The present invention is first heated to melt it, forming fluid liquid, and then processed. Specifically, heating melting can be heated with water bath, hot air heating, oil bath heating, etc., but is not limited thereto. Preferably, the water bath is heated, which is uniform, which can be more uniformly promoted to the melting of marigold extract.
[0028]Specifically, the first preset temperature is 60-80 ° C, exemplary is 61 ° C, 63 ° C, 6...
Embodiment 1
[0046]Example 1 Screening of antioxidants
[0047]Take the marigold immersion cream (commercially available Yoguang Biotechnology Group Co., Ltd., 15.32% of the lutein content) 500g, an antioxidant composition (specific addition amount is measured, the water bath is heated, the temperature is 70 ° C, Until the marigold extract is completely dissolved, the time is 14 h. Among them, the antioxidant is selected from the group consisting of one or several combinations of ethoxyquinoline (EQ), butyl hydroxylholder ether (BHA), TbHQ (TBHQ), by orthogonal law, three Antioxidant conducts ratio. The content of leaf lutein in the molten pre-molten, the content of the lutein in the molten molten liquid was detected, respectively; the loss rate of the lutein was calculated. Leaf lumin loss rate = (total amount of putectin in front of melt - total amount of lutein in molten molten in molten) / Total amount of lutein in front of melt × 100%. See GB / T21517-2008 in the lutein content detection metho...
Embodiment 2
[0052]Embodiment 2 Determination of the amount of antioxidant added during melting
[0053]Take the marigold immersion cream (commercially available Yoguang Biotechnology Group Co., Ltd.), the lutein content is 15.32%) 2000g, the antioxidant composition (the specific amount of addition is measured, the water bath is heated, the temperature is 70 ° C, until The marigold extract is completely dissolved, and the time is 14 h. Among them, antioxidants are mixtures: EQ, BHA, TBHQ; and EQ: BHA: TBHQ = 5: 0.5: 0.1 (weight ratio). The content of leaf lutein in the molten pre-molten, the content of the lutein in the molten molten liquid was detected, respectively; the loss rate of the lutein was calculated. Specific detection method, the method is calculated as in Example 1.
[0054]Test test of different additions of antioxidants on the loss rate of lutein loss during melting process
[0055] Antioxidant added amount / g Leaf lutein content / % in molten liquid Leaf lutein loss rate / % Contrast 1...
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