Tellurium-containing compound, method for preparing tellurium gold nanoparticles and application of tellurium gold nanoparticles in preparation of antitumor drugs

A tellurium compound, 2-te technology, applied in the field of nano-biomedicine, can solve the problems of harsh storage conditions, cumbersome synthesis steps, toxic and side effects, etc., and achieve good thermodynamic stability, broad application prospects, and low toxic and side effects

Active Publication Date: 2021-10-22
TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this kind of nanomedicine has the disadvantages of complex material structure and cumbersome synthesis steps, and it is difficult to achieve effective economic benefits through industrial production.
At the same time, while killing tumor cells, such nano-medicines also have relatively large toxic and side effects on normal cells, requiring surface modification to target small molecules or specific proteins to achieve selective treatment, which will lead to the clinical application of such drugs There are problems with high prices and harsh storage conditions

Method used

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  • Tellurium-containing compound, method for preparing tellurium gold nanoparticles and application of tellurium gold nanoparticles in preparation of antitumor drugs
  • Tellurium-containing compound, method for preparing tellurium gold nanoparticles and application of tellurium gold nanoparticles in preparation of antitumor drugs
  • Tellurium-containing compound, method for preparing tellurium gold nanoparticles and application of tellurium gold nanoparticles in preparation of antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1: based on (HO-EG 6 -C 6 ) 2 Preparation of gold tellurium nanoparticles of -Te (bis(17-hydroxy-3,6,9,12,15-pentaoxoacetyl) 4,4'-telluryl dihexanoate) and chloroauric acid and its preparation Application in antineoplastic drugs

[0054] (1) 88.7mg (HO-EG 6 -C 6 ) 2 -Te was dissolved in 1 mL of deionized water to obtain component A, and 9.6 mg of chloroauric acid was dissolved in 1 mL of deionized water to obtain component B. Fully mix component A and component B in a 5mL reaction bottle to obtain a uniform mixed system. The above mixed system was lyophilized, rinsed three times with 2 mL of dichloromethane, and dried with nitrogen to obtain gold tellurium nanoparticles. where (HO-EG 6 -C 6 ) 2 The synthesis process of -Te molecule is as follows:

[0055] Dissolve 5.64g of hexaethylene glycol in a round-bottomed flask containing 100mL of dichloromethane, and add 4.27g of 6-bromohexanoyl chloride dropwise to the round-bottomed flask through a consta...

Embodiment 2

[0065] Embodiment 2: based on (HO-EG 4 -C 6 ) 2 -Te(bis(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)4,4'-telluryl dihexanoate) with tellurium of chloroauric acid Preparation of gold nanoparticles and its application in the preparation of antitumor drugs

[0066] The difference between this embodiment and Example 1 lies in the preparation of gold tellurium nanoparticles, and all the other steps are the same as in Example 1, specifically:

[0067] 142.0mg (HO-EG 4 -C 6 ) 2-Te was dissolved in 1 mL of ethylene glycol to obtain component A, and 2.6 mg of chloroauric acid was dissolved in 1 mL of dimethyl sulfoxide to obtain component B. Fully mix component A and component B in a 5mL reaction bottle to obtain a uniform mixed system. The above mixed system was dried in a vacuum oven, rinsed three times with 2 mL of tetrahydrofuran, and dried in a vacuum oven to obtain gold tellurium nanoparticles. where (HO-EG 4 -C 6 ) 2 The synthesis process of -Te molecule is as follow...

Embodiment 3

[0069] Embodiment 3: based on (HO-EG 2 -C 6 ) 2 Preparation of gold tellurium nanoparticles of -Te (bis(2-(2-hydroxyethoxy)ethyl) 6,6'-telluryl dihexanoate) and chloroauric acid and its application in the preparation of antitumor drugs

[0070] The difference between this embodiment and Example 1 lies in the preparation of gold tellurium nanoparticles, and all the other steps are the same as in Example 1, specifically:

[0071] 17.8mg (HO-EG 2 -C 6 ) 2 -Te was dissolved in 1 mL of methanol to obtain component A, and 2.0 mg of gold chloride was dissolved in 1 mL of deethylene glycol to obtain component B. Fully mix component A and component B in a 5mL reaction bottle to obtain a uniform mixed system. The above mixed system was dried in a vacuum oven to remove the solvent, rinsed three times with 2 mL of ethyl acetate, and dried with nitrogen to obtain gold tellurium nanoparticles. where (HO-EG 2 -C 6 ) 2 The synthesis process of -Te molecule is as follows:

[0072] D...

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Abstract

The invention discloses a tellurium-containing compound, a method for preparing gold tellurium nanoparticles by using the tellurium gold nanoparticles and the application of the gold tellurium nanoparticles in preparing antitumor drugs. The method utilizes a tellurium compound and a gold chloride ion complex to prepare gold tellurium nanoparticles; the nanometer particles can realize stimulus response under the action of an oxidant. When the above-mentioned gold tellurium nanoparticles are co-incubated with tumor cells, it can be observed that the cell survival rate is significantly reduced; when the above-mentioned gold tellurium nanoparticles are co-incubated with normal cells, the cell survival status is good. Based on the reducibility and coordination interaction of tellurium element, the present invention makes the tellurium-containing compound act as a reducing agent and a stabilizer at the same time. While regulating the molecular structure of the tellurium compound, different material synthesis methods are used to prepare gold tellurium nanoparticles. The prepared material is responsive to oxidative stimuli, and is a potential selective antitumor drug with good prospects for clinical application.

Description

technical field [0001] The invention relates to the field of nano-biomedicine, in particular to a tellurium-containing compound, a method for preparing tellurium gold nanoparticles by using the tellurium gold nanoparticles, and an application of the tellurium gold nanoparticles in antitumor drugs. Background technique [0002] Cancer is one of the common malignant diseases. Because of its rapid development, low cure rate, and high recurrence rate, it causes serious economic and psychological burdens on patients. [0003] The +4-valent tellurium-containing functional structure has potential anti-tumor activity. This type of compound can induce cell apoptosis by inhibiting the active site of the selenol structure in the cell and disrupting the redox balance in the cell. AS101 is a +4-valent tellurium-containing molecule that entered Phase II clinical trials, however, due to its low stability and poor selectivity, further clinical trials could not be achieved. Solving the defe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C395/00C01B19/00A61K33/242A61P35/00A61K33/04
CPCA61K33/04A61P35/00A61K33/242C01B19/007C07C395/00A61K2300/00
Inventor 许华平戴以恒李天予
Owner TSINGHUA UNIV
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