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Traditional Chinese medicine for treating gastric ulcer and application thereof

A technology for gastric ulcer and traditional Chinese medicine, applied in the field of traditional Chinese medicine for treating gastric ulcer, can solve the problems of large side effects and unreported, and achieve the effect of less toxic and side effects and treating gastric ulcer.

Pending Publication Date: 2021-05-07
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment of gastric ulcer generally requires long-term use of western medicine, but western medicine has great side effects on the body, while traditional Chinese medicine has little side effects and can be taken for a long time, and current research has found that most of the traditional Chinese medicine has a miraculous effect on the treatment of gastric ulcer. The role of ulcers has not been reported

Method used

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  • Traditional Chinese medicine for treating gastric ulcer and application thereof
  • Traditional Chinese medicine for treating gastric ulcer and application thereof
  • Traditional Chinese medicine for treating gastric ulcer and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The method for extracting the active ingredients of the sauce by cold immersion extraction method is as follows:

[0025] Sauce head powder is sieved, weigh 300g of sauce head powder, add five times the amount of 80% ethanol to extract, extract at room temperature for 2 days, filter and collect the extract, extract the filter residue for 2-3 times, combine the extract, and concentrate under reduced pressure , drying to obtain 90.4g of powder, add 3L of water to dissolve, add the same amount of ethyl acetate as water for extraction, and obtain 19.0g of ethyl acetate extract, which is the sauce extract. The total phenolic content in the sauce extract was 16.2-22.5% as determined by the Folin-Cioealteau chromogenic method.

Embodiment 2

[0027] The method of extracting the active ingredients of the sauce by the reflux extraction method is as follows:

[0028] The sauce powder was sieved, weighed 300g of sauce powder, added ten times the amount of 95% ethanol aqueous solution, heated and refluxed in a water bath for 3 hours at a temperature of 50 ° C, filtered and extracted the residue repeatedly for 3 times, combined the filtrates, and vortexed After drying, the extract powder (92.4 g) was obtained, and 3 L of water was added to dissolve, and ethyl acetate was added to extract the same amount of water to obtain 20.9 g of ethyl acetate extract, which was the extract. By Folin-Cioealteau chromogenic method, the total phenolic content in this sauce extract is 16.8-18.3%.

Embodiment 3

[0030] The method for extracting the active ingredients of the sauce by ultrasonic extraction is as follows:

[0031] The sauce head powder is sieved, weigh 300g sauce head powder, add five times the amount of 95% ethanol aqueous solution, at 50 ℃ temperature, ultrasonic extraction 60min, power 250W, frequency 50KHz, repeat the extraction 3 times, filter, combine the filtrate, reduce After being concentrated and dried under pressure, the extract of the sauce (88.6 g) was obtained, which was dissolved by adding 3 L of water, and extracted with ethyl acetate in the same amount as water to obtain 17.8 g of the ethyl acetate extract, which was the extract of the sauce. By Folin-Cioealteau chromogenic method, the total phenolic content in this sauce extract is 15.0-17.9%.

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Abstract

The invention provides a traditional Chinese medicine for treating gastric ulcer and application thereof. The effective component of the traditional Chinese medicine is a radix polygoni aubertii extract. An extraction method of the radix polygoni aubertii extract comprises the following steps: crushing radix polygoni aubertii with a pulverizer, performing sieving, adding a solvent into powder for extraction, collecting an extracting solution after filtering, further adding the solvent, performing extraction for 2-3 times, merging extracting solutions, and performing concentrating with a rotary evaporator to extractum; and adding water into the extractum for dissolving and uniform mixing, adding ethyl acetate for extracting for 2-3 times, merging extraction liquid, and performing evaporating to dryness with the rotary evaporator to extractum, to obtain the radix polygoni aubertii extract. The radix polygoni aubertii extract contains 15.0-22.5% of total phenol component. The invention further discloses a repairing effect of the radix polygoni aubertii extract on rat gastric mucosal injury caused by ethanol. The traditional Chinese medicine provided by the invention has a remarkable effect on treating the gastric ulcer.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine for treating gastric ulcer and its application. Background technique [0002] The sauce head is a commonly used Chinese herbal medicine among the Yi people in Yunnan Province. It comes from the tuberous root of the Polygonum Polygonum genus Fallopiadenticuta (Huang) A.J.Litransl.nov. Its taste is astringent and cool, with astringent, antidiarrheal, anti-inflammatory, analgesic and other effects, decoction or powdered to treat dysentery, dyspepsia, chronic hepatitis; taken with wine to treat internal bleeding; fresh smashed or dry powder for external application At the beginning of boils, traumatic bleeding, etc., Yi folks use its tuberous roots to treat chronic hepatitis with good curative effect. [0003] Gastric ulcer is a kind of peptic ulcer caused by the imbalance of defense factor and attack factor of gastric mucosa. Ther...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61P1/04A61P31/04A61P35/00A61K125/00
CPCA61K36/704A61P1/04A61P31/04A61P35/00A61K2236/333A61K2236/35A61K2236/39
Inventor 杨晓艳邹玉林崔秀明向巧曲媛杨野王承潇
Owner KUNMING UNIV OF SCI & TECH
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