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Construction method of radix scrophulariae medicinal material evaluation model and evaluation method of radix scrophulariae medicinal material quality

A technology for constructing methods and evaluating models, which is applied in the field of medicinal material detection to achieve ideal effects of efficiency and accuracy

Pending Publication Date: 2021-05-07
GUANGDONG YIFANG PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the above two methods of evaluating the quality of traditional Chinese medicines have limitations.

Method used

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  • Construction method of radix scrophulariae medicinal material evaluation model and evaluation method of radix scrophulariae medicinal material quality
  • Construction method of radix scrophulariae medicinal material evaluation model and evaluation method of radix scrophulariae medicinal material quality
  • Construction method of radix scrophulariae medicinal material evaluation model and evaluation method of radix scrophulariae medicinal material quality

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preparation example Construction

[0069] 5.2 Preparation of reference substance solution: take appropriate amount of harpagoside, harpagoside, and cinnamic acid reference substance, weigh them accurately, add 50% methanol to make mixtures with concentrations of 66.598 4 μg / mL, 60.844 8 μg / mL, and 21.271 6 μg / mL Reference substance solution.

[0070] 5.3 Preparation of the test solution: take about 0.5 g of the sample powder (passed through a No. 3 sieve), accurately weigh it, put it in a stoppered Erlenmeyer flask, accurately add 25 mL of 50% methanol, weigh it, and perform ultrasonic treatment (power 300W, frequency (45kHz) for 30 minutes, take it out, let it cool, weigh again, make up the lost weight with 50% methanol, shake well, filter, and take the filtrate to obtain the final product.

[0071] 5.4 Linear relationship investigation: Accurately weigh the appropriate amount of reference substances of harpagoside, harpagoside and cinnamic acid, and add 50% methanol to prepare stock solutions of reference sub...

Embodiment 1

[0098] This embodiment provides a method for evaluating the quality of Scrophulariaceae medicinal materials, using the established chromaticity value a 2 and the regression equation one of the total mass percentage of harpaside and harpagoside, the regression equation two of the diameter and the mass percentage of cinnamic acid, by measuring the chromaticity value a of the Scrophulariaceae sample 2 The total mass percentage of harpagoside and harpagoside and the mass percentage of cinnamic acid in Scrophulariae Radix Scrophulariae can be predicted respectively.

[0099] 8 batches (XC-41~XC-48) of Scrophulariaceae medicinal materials that were not used for modeling and met the pharmacopoeia standards and 2 batches (XC-49~XC-50) of Scrophulariae samples whose content did not meet the requirements of the Pharmacopoeia standards were verified , the identification results obtained are shown in Table 10, and the detection efficiency is shown in Table 11.

[0100] Table 10 Identific...

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Abstract

The invention relates to a construction method of a radix scrophulariae medicinal material evaluation model and an evaluation method of a radix scrophulariae medicinal material quality. The construction method comprises the following steps: measuring the contents of harpagide, harpagoside and cinnamic acid in a radix scrophulariae medicinal material; acquiring physical characteristic parameters of the radix scrophulariae medicinal material; establishing a regression equation I of the physical characteristic parameter I of the radix scrophulariae medicinal material and the sum of the contents of harpagide and harpagoside; and establishing a regression equation II of the physical characteristic parameter II of the radix scrophulariae medicinal material and the content of the cinnamic acid. The physical characteristic parameters of the radix scrophulariae medicinal material and the contents of various index active components in the radix scrophulariae medicinal material are combined for evaluation, so that the quality of the radix scrophulariae medicinal material can be evaluated more objectively, accurately, efficiently and comprehensively.

Description

technical field [0001] The invention relates to the technical field of detection of medicinal materials, in particular to a method for constructing an evaluation model of medicinal materials of Scrophulariae Scrophulariae and a method for evaluating the quality of medicinal materials of Scrophulariae Scrophulariae. Background technique [0002] Scrophulariaceae is the dried root of Scrophularia ningpoensis Hemsl, a plant of the family Scrophulariaceae. Sweet, bitter, salty, slightly cold, has the effects of clearing heat and cooling blood, nourishing yin and reducing fire, detoxifying and dispelling stagnation. It is used for heat entering the camp and blood, hot toxins causing spots, febrile diseases affecting yin, red tongue and polydipsia, constipation caused by body fluid injury, cough due to bone steaming, red eyes, sore throat, diphtheria, and other diseases. Studies have shown that the main chemical active components of Scrophulariaceae are iridoid glycosides (harpag...

Claims

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Application Information

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IPC IPC(8): G16C20/70G06F17/18
CPCG06F17/18G16C20/70
Inventor 魏梅梁丽金邓怡芳黄瑶汪梅孙冬梅程学仁钟文峰彭帮贵
Owner GUANGDONG YIFANG PHARMA
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