Application of acylthiourea compound in preparation of drugs for treating or preventing herpes simplex virus type 1 infection

A technology of herpes simplex virus and acylthiourea, applied in the field of medicine, can solve the problems of drug-resistant virus strains and inability to cure infection completely

Active Publication Date: 2021-05-18
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although these drugs have a significant effect in the treatment of many acute infections, helping patients reduce the severity and frequency of symptoms, they cannot completely cure the infection, and long-term use can lead to the emergence of drug-resistant virus strains, especially for immunocompromised patients. This situation occurs, so it is necessary to find other ways to resist HSV-1 infection and replication drugs

Method used

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  • Application of acylthiourea compound in preparation of drugs for treating or preventing herpes simplex virus type 1 infection
  • Application of acylthiourea compound in preparation of drugs for treating or preventing herpes simplex virus type 1 infection
  • Application of acylthiourea compound in preparation of drugs for treating or preventing herpes simplex virus type 1 infection

Examples

Experimental program
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Effect test

Embodiment 1

[0020] [Example 1] Biological activity test of acylthiourea compounds

[0021] (1) Determination of cytotoxicity of acylthiourea compounds:

[0022] Yellow thiazolan, referred to as MTT, can enter the cell through the cell membrane, and the amber dehydrogenase in the mitochondria of living cells can reduce the exogenous MTT to blue-purple needle-shaped Formazan crystals that are insoluble in water and deposit in the cell. The crystals can be dissolved by 20% (mass to volume) SDS, and the light absorption value is measured at a wavelength of 595nm by an enzyme-linked immunosorbent detector, which can indirectly reflect the number of cells.

[0023] During the experiment, Vero cells were mixed at 2×10 per well 4 The density of the cells was transferred to a 96-well plate, and after culturing at 37°C for 24 hours, the medium was aspirated, and the cell culture medium containing various concentration gradient compounds was added to each well. After 24 hours, 5 mg / mL MTT solution...

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Abstract

The invention discloses application of an acylthiourea compound in preparation of drugs for treating or preventing herpes simplex virus type 1 infection and belongs to the technical field of medicines. Proven by cytotoxicity and herpes simplex virus type 1 resisting activity results, the compound represented by a formula (I) has low toxicity to cells, has very good herpes simplex virus type 1 infection and replication resisting activity and high selectivity and can be applied to the preparation of the drugs for treating or preventing the herpes simplex virus type 1 infection.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of an acylthiourea compound in the preparation of medicines for treating or preventing herpes simplex virus type I infection. Background technique [0002] Herpes virus is a double-stranded DNA virus, 8 types have been found to cause human infection, according to biological and genetic characteristics, can be divided into 3 subtypes (α, β and γ). Alpha herpes viruses include herpes simplex virus and varicella zoster virus. Herpes simplex virus (HSV) is a ubiquitous pathogen with frequent infections all over the world. According to reports, 60% to 95% of people will be infected at least once in their lives. Herpes simplex virus HSV-1 primarily infects oral-associated areas (lips, tongue, oral mucosa), while HSV-2 primarily affects the genital area. At the same time, they may also cause fatal viral encephalitis and stromal keratitis. [0003] At pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/17A61K31/381A61K31/4402A61K31/47A61K31/4196A61K31/18A61P31/22
CPCA61K31/17A61K31/381A61K31/4402A61K31/47A61K31/4196A61K31/18A61P31/22
Inventor 吴叔文周海兵蓝柯许智超刘欣瑾
Owner WUHAN UNIV
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