Thermally-induced physical cross-linked colored hydrogel and preparation method thereof

A physical crosslinking and hydrogel technology, which is applied in the field of thermally induced physical crosslinking color hydrogel and its preparation, can solve the problems of cumbersome preparation process, non-reversibility, irreversible sol-gel process, etc. To achieve the effect of simple process

Active Publication Date: 2021-05-18
ANHUI MICRODELIVERY SMART MICROCAPSULE SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of cross-linking belongs to chemical cross-linking and is not reversible
In addition, such hydrogels usually h

Method used

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  • Thermally-induced physical cross-linked colored hydrogel and preparation method thereof
  • Thermally-induced physical cross-linked colored hydrogel and preparation method thereof
  • Thermally-induced physical cross-linked colored hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1-9

[0031] Examples 1-9 are examples of preparation of P(NIPAm-TBA-Aphe) copolymerized nano-hydrogels of the present invention. Through thermally induced physical crosslinking, a macroscopic jelly-like colored hydrogel is obtained and has reversibility.

Embodiment 1

[0054] Take about 0.9231g monomeric N-isopropylacrylamide (NIPAm), 0.1526g monomeric N-tert-butylacrylamide, 0.0962g monomeric L-N-propionylphenylalanine (Aphe), 0.0295g crosslinker Dissolve N,N'-methylenebisacrylamide, 0.0408g emulsifier sodium lauryl sulfate in 95 ml deionized water, and bubble N at room temperature 2 Deoxygenation, magnetic stirring for 30 minutes;

[0055] The reaction temperature was raised to 70 °C, and under N 2 Keep warm for 30 minutes under protection;

[0056] Then about 0.0679 g of initiator ammonium persulfate was dissolved in 5 ml of deionized water, and added to the above solution, keeping N 2 atmosphere, continue to react for 4 hours;

[0057] Then soak the obtained reactant in deionized water and dialyze for 7 days, change the water three times a day to remove residual reaction raw materials and electrolytes in the reaction system. The molecular weight cut-off of the dialysis bag used is 8000-14000. That is, P (NIPAm-TBA-Aphe) ternary copo...

Embodiment 2

[0063] Take about 0.9062g monomeric N-isopropylacrylamide (NIPAm), 0.1512g monomeric N-tert-butylacrylamide, 0.1298g monomeric L-N-propionylphenylalanine (Aphe), 0.0306g crosslinker Dissolve N,N'-methylene bisacrylamide, 0.0398g emulsifier sodium lauryl sulfate in 95 ml deionized water, and bubble N at room temperature 2 Deoxygenation, magnetic stirring for 30 minutes;

[0064] The reaction temperature was raised to 70 °C, and under N 2 Keep warm for 30 minutes under protection;

[0065] Then about 0.0615 g of initiator ammonium persulfate was dissolved in 5 ml of deionized water, and added to the above solution, keeping N 2 atmosphere, continue to react for 4 hours;

[0066] Then soak the obtained reactant in deionized water and dialyze for 7 days, change the water three times a day to remove residual reaction raw materials and electrolytes in the reaction system. The molecular weight cut-off of the dialysis bag used is 8000-14000. That is, P (NIPAm-TBA-Aphe) ternary cop...

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Abstract

The invention particularly relates to thermally-induced physical cross-linked colored hydrogel and a preparation method thereof. The preparation method comprises the following steps: firstly, by taking N-isopropylacrylamide (NIPAm) as a functional monomer for providing temperature sensitivity for a polymer, taking N-tert-butyl acrylamide (TBA) as a hydrophobic monomer and taking L-N-propionyl phenylalanine (Aphe) as a hydrophilic monomer, carrying out copolymerization by controlling and adjusting the introduction amount of the Aphe, so as to obtain the P (NIPAm-TBA-Aphe) ternary copolymerized nano hydrogel with temperature responsiveness. Then, temperature is adopted to trigger in-situ implementation of a sol-gelation process and keep a bright structural color: the nano hydrogel is heated within a certain temperature range, the concentration range of the nano hydrogel is adjusted, the nano hydrogel is converted from a flowable solution state to a non-flowable macroscopic jelly-like hydrogel state, meanwhile, the hydrogel has the bright structural color, and in addition, the in-situ sol-gel conversion has reversibility.

Description

technical field [0001] The invention belongs to the field of nanometer hydrogel and its preparation, and in particular relates to a thermally induced physical cross-linked color hydrogel and its preparation method. Background technique [0002] At present, most temperature-triggered thermally physically crosslinked hydrogels are based on the preparation of poly(N-isopropylacrylamide) (PNIPAm) hydrogels. This type of hydrogel dispersion can form physical crosslinking sites through the entanglement of hydrophobic groups of PNIPAm above the phase transition temperature, and in situ sol-gel transformation, thereby obtaining thermally induced physical crosslinking. Jelly-like hydrogel. [0003] However, the severe shrinkage of the PNIPAm component above the phase transition temperature will lead to an increase in the turbidity of the hydrogel, and thus the color of the obtained physically crosslinked hydrogel will change to milky white. For example, the PNIPAm-based nanohydroge...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08F220/54C08F220/36C08F222/38C08L33/24
CPCC08J3/075C08J3/247C08F220/54C08J2333/24C08F220/365C08F222/385Y02A50/30
Inventor 鲁希华李雪婷李晓晓
Owner ANHUI MICRODELIVERY SMART MICROCAPSULE SCI & TECH CO LTD
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